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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for FRS3 |
Gene summary |
Gene information | Gene symbol | FRS3 | Gene ID | 10817 |
Gene name | fibroblast growth factor receptor substrate 3 | |
Synonyms | FRS2-beta|FRS2B|FRS2beta|SNT-2|SNT2 | |
Cytomap | 6p21.1 | |
Type of gene | protein-coding | |
Description | fibroblast growth factor receptor substrate 3FGFR substrate 3FGFR-signaling adaptor SNT2suc1-associated neurotrophic factor target 2 (FGFR signalling adaptor)testicular tissue protein Li 71 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for FRS3 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | DOWN | ENST00000259748.6 | FRS3-201:protein_coding:FRS3 | 1.120627e+02 | -2.274093e+00 | 3.254280e-03 | 1.379765e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for FRS3 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_140144 | chr6 | 41772844:41772959:41775419:41775605:41776922:41777005 | 41775419:41775605 |
exon_skip_210576 | chr6 | 41776922:41777010:41778033:41778176:41779816:41779900 | 41778033:41778176 |
exon_skip_239681 | chr6 | 41775563:41775605:41776922:41777010:41778033:41778176 | 41776922:41777010 |
exon_skip_259654 | chr6 | 41776922:41777010:41777485:41777827:41778033:41778176 | 41777485:41777827 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for FRS3 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000373018 | 41776922 | 41777010 | 3UTR-3CDS |
ENST00000373018 | 41778033 | 41778176 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000373018 | 41776922 | 41777010 | 3UTR-3CDS |
ENST00000373018 | 41778033 | 41778176 | 3UTR-3UTR |
ENST00000259748 | 41775419 | 41775605 | Frame-shift |
ENST00000373018 | 41775419 | 41775605 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for FRS3 |
p-ENSG00000137218_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in FRS3 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000373018 | 41778033 | 41778176 | hsa-miR-6736-3p | chr6:41778050-41778057 | 8mer-1a | chr6:41778047-41778070 | 153.00 | -23.99 |
Mayo | ENST00000373018 | 41778033 | 41778176 | hsa-miR-3158-5p | chr6:41778129-41778136 | 8mer-1a | chr6:41778115-41778141 | 159.00 | -25.27 |
Mayo | ENST00000373018 | 41778033 | 41778176 | hsa-miR-6505-3p | chr6:41778136-41778143 | 8mer-1a | chr6:41778124-41778145 | 158.00 | -18.24 |
Mayo | ENST00000373018 | 41778033 | 41778176 | hsa-miR-1225-3p | chr6:41778168-41778175 | 8mer-1a | chr6:41778153-41778175 | 149.00 | -29.34 |
Mayo | ENST00000373018 | 41778033 | 41778176 | hsa-miR-4749-3p | chr6:41778064-41778071 | 8mer-1a | chr6:41778056-41778075 | 169.00 | -41.77 |
Mayo | ENST00000373018 | 41778033 | 41778176 | hsa-miR-4771 | chr6:41778127-41778134 | 8mer-1a | chr6:41778115-41778141 | 159.00 | -25.27 |
Mayo | ENST00000373018 | 41778033 | 41778176 | hsa-miR-4776-3p | chr6:41778118-41778125 | 8mer-1a | chr6:41778115-41778141 | 159.00 | -25.27 |
Mayo | ENST00000373018 | 41778033 | 41778176 | hsa-miR-4796-3p | chr6:41778085-41778092 | 8mer-1a | chr6:41778077-41778101 | 153.00 | -24.48 |
Mayo | ENST00000373018 | 41778033 | 41778176 | hsa-miR-4659a-5p | chr6:41778117-41778124 | 8mer-1a | chr6:41778115-41778141 | 159.00 | -25.27 |
Mayo | ENST00000373018 | 41778033 | 41778176 | hsa-miR-4659b-5p | chr6:41778117-41778124 | 8mer-1a | chr6:41778115-41778141 | 159.00 | -25.27 |
ROSMAP | ENST00000373018 | 41778033 | 41778176 | hsa-miR-6736-3p | chr6:41778050-41778057 | 8mer-1a | chr6:41778047-41778070 | 153.00 | -23.99 |
ROSMAP | ENST00000373018 | 41778033 | 41778176 | hsa-miR-3158-5p | chr6:41778129-41778136 | 8mer-1a | chr6:41778115-41778141 | 159.00 | -25.27 |
ROSMAP | ENST00000373018 | 41778033 | 41778176 | hsa-miR-6505-3p | chr6:41778136-41778143 | 8mer-1a | chr6:41778124-41778145 | 158.00 | -18.24 |
ROSMAP | ENST00000373018 | 41778033 | 41778176 | hsa-miR-1225-3p | chr6:41778168-41778175 | 8mer-1a | chr6:41778153-41778175 | 149.00 | -29.34 |
ROSMAP | ENST00000373018 | 41778033 | 41778176 | hsa-miR-4749-3p | chr6:41778064-41778071 | 8mer-1a | chr6:41778056-41778075 | 169.00 | -41.77 |
ROSMAP | ENST00000373018 | 41778033 | 41778176 | hsa-miR-4771 | chr6:41778127-41778134 | 8mer-1a | chr6:41778115-41778141 | 159.00 | -25.27 |
ROSMAP | ENST00000373018 | 41778033 | 41778176 | hsa-miR-4776-3p | chr6:41778118-41778125 | 8mer-1a | chr6:41778115-41778141 | 159.00 | -25.27 |
ROSMAP | ENST00000373018 | 41778033 | 41778176 | hsa-miR-4796-3p | chr6:41778085-41778092 | 8mer-1a | chr6:41778077-41778101 | 153.00 | -24.48 |
ROSMAP | ENST00000373018 | 41778033 | 41778176 | hsa-miR-4659a-5p | chr6:41778117-41778124 | 8mer-1a | chr6:41778115-41778141 | 159.00 | -25.27 |
ROSMAP | ENST00000373018 | 41778033 | 41778176 | hsa-miR-4659b-5p | chr6:41778117-41778124 | 8mer-1a | chr6:41778115-41778141 | 159.00 | -25.27 |
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SNVs in the skipped exons for FRS3 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for FRS3 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FRS3 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for FRS3 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for FRS3 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FRS3 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |