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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for STARD10 |
Gene summary |
Gene information | Gene symbol | STARD10 | Gene ID | 10809 |
Gene name | StAR related lipid transfer domain containing 10 | |
Synonyms | CGI-52|NY-CO-28|PCTP2|SDCCAG28 | |
Cytomap | 11q13.4 | |
Type of gene | protein-coding | |
Description | START domain-containing protein 10PCTP-LPCTP-like proteinSTART domain containing 10StAR-related lipid transfer (START) domain containing 10antigen NY-CO-28serologically defined colon cancer antigen 28stAR-related lipid transfer protein 10 | |
Modification date | 20200313 | |
UniProtAcc | A0A024R5G8, A0A024R5L8, F5GWK5, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for STARD10 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
DLPFC | UP | ENST00000537947.5 | STARD10-210:protein_coding:STARD10 | 2.253105e+01 | 1.292270e+00 | 7.898449e-05 | 5.954008e-03 |
PCC | UP | ENST00000538437.5 | STARD10-212:lncRNA:STARD10 | 2.315446e+01 | 1.188001e+00 | 3.289469e-09 | 4.518273e-06 |
PCC | UP | ENST00000537947.5 | STARD10-210:protein_coding:STARD10 | 3.636448e+01 | 9.715805e-01 | 1.611690e-07 | 7.138206e-05 |
PCC | UP | ENST00000536728.5 | STARD10-208:protein_coding:STARD10 | 2.218971e+00 | 3.322575e+00 | 1.175990e-05 | 1.426171e-03 |
PCC | UP | ENST00000400925.2 | STARD10-202:protein_coding:STARD10 | 1.993975e+00 | 8.340063e-01 | 8.430401e-04 | 2.292710e-02 |
PG | UP | ENST00000545082.5 | STARD10-220:protein_coding:STARD10 | 1.540286e+00 | 2.202092e+00 | 2.608896e-03 | 2.885542e-02 |
CB | UP | ENST00000535267.1 | STARD10-205:retained_intron:STARD10 | 8.050714e+01 | 1.012664e+00 | 2.577767e-12 | 3.269268e-10 |
CB | UP | ENST00000536290.5 | STARD10-206:protein_coding:STARD10 | 1.047034e+01 | 1.419590e+00 | 8.961512e-07 | 1.365698e-05 |
CB | UP | ENST00000537947.5 | STARD10-210:protein_coding:STARD10 | 4.394946e+01 | 8.650362e-01 | 5.919403e-03 | 2.262275e-02 |
TC | UP | ENST00000535267.1 | STARD10-205:retained_intron:STARD10 | 3.358952e+01 | 1.112188e+00 | 1.452482e-08 | 1.231798e-06 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for STARD10 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_28497 | chr11 | 72755701:72755753:72757767:72757884:72758530:72758633 | 72757767:72757884 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for STARD10 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000334805 | 72757767 | 72757884 | Frame-shift |
ENST00000543304 | 72757767 | 72757884 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000334805 | 72757767 | 72757884 | Frame-shift |
ENST00000543304 | 72757767 | 72757884 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000334805 | 72757767 | 72757884 | Frame-shift |
ENST00000543304 | 72757767 | 72757884 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for STARD10 |
p-ENSG00000214530_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in STARD10 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for STARD10 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for STARD10 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for STARD10 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for STARD10 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | RBM4 | exon_skip_28497 | 6.075807e-01 | 2.037575e-17 |
IFG | RBM6 | exon_skip_28497 | 4.046068e-01 | 4.034036e-02 |
IFG | MBNL1 | exon_skip_28497 | 5.220733e-01 | 6.224359e-03 |
IFG | ENOX1 | exon_skip_28497 | 6.367123e-01 | 4.700361e-04 |
IFG | RBM4 | exon_skip_28497 | 4.547533e-01 | 1.959122e-02 |
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RelatedDrugs for STARD10 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STARD10 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |