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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for MAP3K2 |
 Gene summary |
| Gene information | Gene symbol | MAP3K2 | Gene ID | 10746 |
| Gene name | mitogen-activated protein kinase kinase kinase 2 | |
| Synonyms | MEKK2|MEKK2B | |
| Cytomap | 2q14.3 | |
| Type of gene | protein-coding | |
| Description | mitogen-activated protein kinase kinase kinase 2MAP/ERK kinase kinase 2MAPK/ERK kinase kinase 2MEK kinase 2MEKK 2 | |
| Modification date | 20200329 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MAP3K2 | GO:0045893 | positive regulation of transcription, DNA-templated | 14515274 |
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Gene structures and expression levels for MAP3K2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000169967
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MAP3K2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_88686 | chr2 | 127329921:127330008:127330392:127330505:127335870:127335969 | 127330392:127330505 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for MAP3K2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000344908 | 127330392 | 127330505 | In-frame |
| ENST00000409947 | 127330392 | 127330505 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000344908 | 127330392 | 127330505 | In-frame |
| ENST00000409947 | 127330392 | 127330505 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000344908 | 127330392 | 127330505 | In-frame |
| ENST00000409947 | 127330392 | 127330505 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MAP3K2 |
p-ENSG00000169967_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000344908 | 2152 | 619 | 127330392 | 127330505 | 365 | 477 | 88 | 125 |
| ENST00000409947 | 11009 | 619 | 127330392 | 127330505 | 548 | 660 | 88 | 125 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000344908 | 2152 | 619 | 127330392 | 127330505 | 365 | 477 | 88 | 125 |
| ENST00000409947 | 11009 | 619 | 127330392 | 127330505 | 548 | 660 | 88 | 125 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000344908 | 2152 | 619 | 127330392 | 127330505 | 365 | 477 | 88 | 125 |
| ENST00000409947 | 11009 | 619 | 127330392 | 127330505 | 548 | 660 | 88 | 125 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y2U5 | 88 | 125 | 89 | 92 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NPT |
| Q9Y2U5 | 88 | 125 | 89 | 92 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NPT |
| Q9Y2U5 | 88 | 125 | 114 | 121 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NPT |
| Q9Y2U5 | 88 | 125 | 114 | 121 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NPT |
| Q9Y2U5 | 88 | 125 | 1 | 619 | Chain | ID=PRO_0000086243;Note=Mitogen-activated protein kinase kinase kinase 2 |
| Q9Y2U5 | 88 | 125 | 1 | 619 | Chain | ID=PRO_0000086243;Note=Mitogen-activated protein kinase kinase kinase 2 |
| Q9Y2U5 | 88 | 125 | 43 | 122 | Domain | Note=PB1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01081 |
| Q9Y2U5 | 88 | 125 | 43 | 122 | Domain | Note=PB1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01081 |
| Q9Y2U5 | 88 | 125 | 96 | 108 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NPT |
| Q9Y2U5 | 88 | 125 | 96 | 108 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NPT |
| Q9Y2U5 | 88 | 125 | 110 | 110 | Natural variant | ID=VAR_040682;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55767983,PMID:17344846 |
| Q9Y2U5 | 88 | 125 | 110 | 110 | Natural variant | ID=VAR_040682;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55767983,PMID:17344846 |
| Q9Y2U5 | 88 | 125 | 112 | 112 | Natural variant | ID=VAR_040683;Note=In a lung large cell carcinoma sample%3B somatic mutation. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 |
| Q9Y2U5 | 88 | 125 | 112 | 112 | Natural variant | ID=VAR_040683;Note=In a lung large cell carcinoma sample%3B somatic mutation. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 |
| Q9Y2U5 | 88 | 125 | 103 | 103 | Sequence conflict | Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9Y2U5 | 88 | 125 | 103 | 103 | Sequence conflict | Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9Y2U5 | 88 | 125 | 103 | 103 | Sequence conflict | Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9Y2U5 | 88 | 125 | 103 | 103 | Sequence conflict | Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y2U5 | 88 | 125 | 89 | 92 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NPT |
| Q9Y2U5 | 88 | 125 | 89 | 92 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NPT |
| Q9Y2U5 | 88 | 125 | 114 | 121 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NPT |
| Q9Y2U5 | 88 | 125 | 114 | 121 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NPT |
| Q9Y2U5 | 88 | 125 | 1 | 619 | Chain | ID=PRO_0000086243;Note=Mitogen-activated protein kinase kinase kinase 2 |
| Q9Y2U5 | 88 | 125 | 1 | 619 | Chain | ID=PRO_0000086243;Note=Mitogen-activated protein kinase kinase kinase 2 |
| Q9Y2U5 | 88 | 125 | 43 | 122 | Domain | Note=PB1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01081 |
| Q9Y2U5 | 88 | 125 | 43 | 122 | Domain | Note=PB1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01081 |
| Q9Y2U5 | 88 | 125 | 96 | 108 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NPT |
| Q9Y2U5 | 88 | 125 | 96 | 108 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NPT |
| Q9Y2U5 | 88 | 125 | 110 | 110 | Natural variant | ID=VAR_040682;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55767983,PMID:17344846 |
| Q9Y2U5 | 88 | 125 | 110 | 110 | Natural variant | ID=VAR_040682;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55767983,PMID:17344846 |
| Q9Y2U5 | 88 | 125 | 112 | 112 | Natural variant | ID=VAR_040683;Note=In a lung large cell carcinoma sample%3B somatic mutation. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 |
| Q9Y2U5 | 88 | 125 | 112 | 112 | Natural variant | ID=VAR_040683;Note=In a lung large cell carcinoma sample%3B somatic mutation. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 |
| Q9Y2U5 | 88 | 125 | 103 | 103 | Sequence conflict | Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9Y2U5 | 88 | 125 | 103 | 103 | Sequence conflict | Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9Y2U5 | 88 | 125 | 103 | 103 | Sequence conflict | Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9Y2U5 | 88 | 125 | 103 | 103 | Sequence conflict | Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y2U5 | 88 | 125 | 89 | 92 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NPT |
| Q9Y2U5 | 88 | 125 | 89 | 92 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NPT |
| Q9Y2U5 | 88 | 125 | 114 | 121 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NPT |
| Q9Y2U5 | 88 | 125 | 114 | 121 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NPT |
| Q9Y2U5 | 88 | 125 | 1 | 619 | Chain | ID=PRO_0000086243;Note=Mitogen-activated protein kinase kinase kinase 2 |
| Q9Y2U5 | 88 | 125 | 1 | 619 | Chain | ID=PRO_0000086243;Note=Mitogen-activated protein kinase kinase kinase 2 |
| Q9Y2U5 | 88 | 125 | 43 | 122 | Domain | Note=PB1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01081 |
| Q9Y2U5 | 88 | 125 | 43 | 122 | Domain | Note=PB1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01081 |
| Q9Y2U5 | 88 | 125 | 96 | 108 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NPT |
| Q9Y2U5 | 88 | 125 | 96 | 108 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2NPT |
| Q9Y2U5 | 88 | 125 | 110 | 110 | Natural variant | ID=VAR_040682;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55767983,PMID:17344846 |
| Q9Y2U5 | 88 | 125 | 110 | 110 | Natural variant | ID=VAR_040682;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55767983,PMID:17344846 |
| Q9Y2U5 | 88 | 125 | 112 | 112 | Natural variant | ID=VAR_040683;Note=In a lung large cell carcinoma sample%3B somatic mutation. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 |
| Q9Y2U5 | 88 | 125 | 112 | 112 | Natural variant | ID=VAR_040683;Note=In a lung large cell carcinoma sample%3B somatic mutation. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 |
| Q9Y2U5 | 88 | 125 | 103 | 103 | Sequence conflict | Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9Y2U5 | 88 | 125 | 103 | 103 | Sequence conflict | Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9Y2U5 | 88 | 125 | 103 | 103 | Sequence conflict | Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9Y2U5 | 88 | 125 | 103 | 103 | Sequence conflict | Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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3'-UTR located exon skipping events that lost miRNA binding sites in MAP3K2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for MAP3K2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MAP3K2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAP3K2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for MAP3K2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for MAP3K2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q9Y2U5 | approved | DB06616 | Bosutinib | small molecule | Q9Y2U5 |
| Q9Y2U5 | approved|investigational | DB12010 | Fostamatinib | small molecule | Q9Y2U5 |
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RelatedDiseases for MAP3K2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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