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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for RAI2 |
Gene summary |
Gene information | Gene symbol | RAI2 | Gene ID | 10742 |
Gene name | retinoic acid induced 2 | |
Synonyms | - | |
Cytomap | Xp22.13 | |
Type of gene | protein-coding | |
Description | retinoic acid-induced protein 2 | |
Modification date | 20200327 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for RAI2 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | UP | ENST00000495936.6 | ORAI2-208:protein_coding:ORAI2 | 2.035882e+03 | 1.008511e+00 | 1.184543e-17 | 1.774355e-14 |
CB | UP | ENST00000488996.1 | ORAI2-207:lncRNA:ORAI2 | 2.845134e+01 | 9.121243e-01 | 5.207156e-13 | 8.690270e-11 |
CB | UP | ENST00000498661.5 | ORAI2-209:protein_coding:ORAI2 | 2.670876e+01 | 1.169348e+00 | 3.655598e-12 | 4.347172e-10 |
CB | UP | ENST00000482237.5 | ORAI2-206:protein_coding:ORAI2 | 2.030174e+00 | 1.305722e+00 | 6.642378e-07 | 1.058973e-05 |
CB | UP | ENST00000403646.7 | ORAI2-202:protein_coding:ORAI2 | 1.399967e+02 | 1.419021e+00 | 2.516979e-05 | 2.299270e-04 |
CB | UP | ENST00000356387.6 | ORAI2-201:protein_coding:ORAI2 | 2.142445e+02 | 1.233191e+00 | 4.346322e-05 | 3.651707e-04 |
CB | UP | ENST00000473939.1 | ORAI2-204:protein_coding:ORAI2 | 1.323442e+02 | 1.440663e+00 | 4.521615e-03 | 1.811902e-02 |
CB | UP | ENST00000611770.4 | ORAI2-210:protein_coding:ORAI2 | 2.538339e+02 | 8.552313e-01 | 1.013019e-02 | 3.513261e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for RAI2 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_109530 | chrX | 17801876:17802034:17837537:17837730:17860509:17860707 | 17837537:17837730 |
exon_skip_154802 | chrX | 17801876:17802034:17837537:17837733:17861098:17861236 | 17837537:17837733 |
exon_skip_293705 | chrX | 17801876:17802034:17837537:17837733:17861098:17861337 | 17837537:17837733 |
exon_skip_52252 | chrX | 17801876:17802034:17837537:17837730:17861098:17861236 | 17837537:17837730 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for RAI2 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000331511 | 17837537 | 17837730 | 3UTR-3UTR |
ENST00000360011 | 17837537 | 17837730 | 3UTR-3UTR |
ENST00000545871 | 17837537 | 17837733 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000331511 | 17837537 | 17837730 | 3UTR-3UTR |
ENST00000360011 | 17837537 | 17837730 | 3UTR-3UTR |
ENST00000545871 | 17837537 | 17837733 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for RAI2 |
p-ENSG00000131831_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in RAI2 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000360011 | 17837537 | 17837730 | hsa-miR-4251 | chrX:17837588-17837595 | 8mer-1a | chrX:17837583-17837611 | 140.00 | -19.92 |
Mayo | ENST00000545871 | 17837537 | 17837733 | hsa-miR-4251 | chrX:17837588-17837595 | 8mer-1a | chrX:17837583-17837611 | 140.00 | -19.92 |
Mayo | ENST00000360011 | 17837537 | 17837730 | hsa-miR-3116 | chrX:17837627-17837634 | 8mer-1a | chrX:17837612-17837634 | 154.00 | -23.08 |
Mayo | ENST00000545871 | 17837537 | 17837733 | hsa-miR-3116 | chrX:17837627-17837634 | 8mer-1a | chrX:17837612-17837634 | 154.00 | -23.08 |
Mayo | ENST00000360011 | 17837537 | 17837730 | hsa-miR-146b-5p | chrX:17837586-17837593 | 8mer-1a | chrX:17837569-17837593 | 145.00 | -16.05 |
Mayo | ENST00000545871 | 17837537 | 17837733 | hsa-miR-146b-5p | chrX:17837586-17837593 | 8mer-1a | chrX:17837569-17837593 | 145.00 | -16.05 |
Mayo | ENST00000360011 | 17837537 | 17837730 | hsa-miR-6505-3p | chrX:17837678-17837685 | 8mer-1a | chrX:17837670-17837695 | 157.00 | -27.23 |
Mayo | ENST00000545871 | 17837537 | 17837733 | hsa-miR-6505-3p | chrX:17837678-17837685 | 8mer-1a | chrX:17837670-17837695 | 157.00 | -27.23 |
Mayo | ENST00000360011 | 17837537 | 17837730 | hsa-miR-625-5p | chrX:17837664-17837671 | 8mer-1a | chrX:17837662-17837683 | 163.00 | -20.40 |
Mayo | ENST00000545871 | 17837537 | 17837733 | hsa-miR-625-5p | chrX:17837664-17837671 | 8mer-1a | chrX:17837662-17837683 | 163.00 | -20.40 |
Mayo | ENST00000360011 | 17837537 | 17837730 | hsa-miR-7153-5p | chrX:17837586-17837593 | 8mer-1a | chrX:17837569-17837593 | 145.00 | -16.05 |
Mayo | ENST00000545871 | 17837537 | 17837733 | hsa-miR-7153-5p | chrX:17837586-17837593 | 8mer-1a | chrX:17837569-17837593 | 145.00 | -16.05 |
Mayo | ENST00000360011 | 17837537 | 17837730 | hsa-miR-146a-5p | chrX:17837586-17837593 | 8mer-1a | chrX:17837569-17837593 | 145.00 | -16.05 |
Mayo | ENST00000545871 | 17837537 | 17837733 | hsa-miR-146a-5p | chrX:17837586-17837593 | 8mer-1a | chrX:17837569-17837593 | 145.00 | -16.05 |
Mayo | ENST00000360011 | 17837537 | 17837730 | hsa-miR-1275 | chrX:17837665-17837672 | 8mer-1a | chrX:17837662-17837683 | 163.00 | -20.40 |
Mayo | ENST00000545871 | 17837537 | 17837733 | hsa-miR-1275 | chrX:17837665-17837672 | 8mer-1a | chrX:17837662-17837683 | 163.00 | -20.40 |
Mayo | ENST00000360011 | 17837537 | 17837730 | hsa-miR-6840-3p | chrX:17837720-17837727 | 8mer-1a | chrX:17837706-17837727 | 140.00 | -21.18 |
Mayo | ENST00000545871 | 17837537 | 17837733 | hsa-miR-6840-3p | chrX:17837720-17837727 | 8mer-1a | chrX:17837706-17837727 | 140.00 | -21.18 |
Mayo | ENST00000360011 | 17837537 | 17837730 | hsa-miR-6845-3p | chrX:17837673-17837680 | 8mer-1a | chrX:17837670-17837695 | 157.00 | -27.23 |
Mayo | ENST00000545871 | 17837537 | 17837733 | hsa-miR-6845-3p | chrX:17837673-17837680 | 8mer-1a | chrX:17837670-17837695 | 157.00 | -27.23 |
Mayo | ENST00000360011 | 17837537 | 17837730 | hsa-miR-4665-5p | chrX:17837665-17837672 | 8mer-1a | chrX:17837662-17837683 | 163.00 | -20.40 |
Mayo | ENST00000545871 | 17837537 | 17837733 | hsa-miR-4665-5p | chrX:17837665-17837672 | 8mer-1a | chrX:17837662-17837683 | 163.00 | -20.40 |
ROSMAP | ENST00000360011 | 17837537 | 17837730 | hsa-miR-4251 | chrX:17837588-17837595 | 8mer-1a | chrX:17837583-17837611 | 140.00 | -19.92 |
ROSMAP | ENST00000545871 | 17837537 | 17837733 | hsa-miR-4251 | chrX:17837588-17837595 | 8mer-1a | chrX:17837583-17837611 | 140.00 | -19.92 |
ROSMAP | ENST00000360011 | 17837537 | 17837730 | hsa-miR-3116 | chrX:17837627-17837634 | 8mer-1a | chrX:17837612-17837634 | 154.00 | -23.08 |
ROSMAP | ENST00000545871 | 17837537 | 17837733 | hsa-miR-3116 | chrX:17837627-17837634 | 8mer-1a | chrX:17837612-17837634 | 154.00 | -23.08 |
ROSMAP | ENST00000360011 | 17837537 | 17837730 | hsa-miR-146b-5p | chrX:17837586-17837593 | 8mer-1a | chrX:17837569-17837593 | 145.00 | -16.05 |
ROSMAP | ENST00000545871 | 17837537 | 17837733 | hsa-miR-146b-5p | chrX:17837586-17837593 | 8mer-1a | chrX:17837569-17837593 | 145.00 | -16.05 |
ROSMAP | ENST00000360011 | 17837537 | 17837730 | hsa-miR-6505-3p | chrX:17837678-17837685 | 8mer-1a | chrX:17837670-17837695 | 157.00 | -27.23 |
ROSMAP | ENST00000545871 | 17837537 | 17837733 | hsa-miR-6505-3p | chrX:17837678-17837685 | 8mer-1a | chrX:17837670-17837695 | 157.00 | -27.23 |
ROSMAP | ENST00000360011 | 17837537 | 17837730 | hsa-miR-625-5p | chrX:17837664-17837671 | 8mer-1a | chrX:17837662-17837683 | 163.00 | -20.40 |
ROSMAP | ENST00000545871 | 17837537 | 17837733 | hsa-miR-625-5p | chrX:17837664-17837671 | 8mer-1a | chrX:17837662-17837683 | 163.00 | -20.40 |
ROSMAP | ENST00000360011 | 17837537 | 17837730 | hsa-miR-7153-5p | chrX:17837586-17837593 | 8mer-1a | chrX:17837569-17837593 | 145.00 | -16.05 |
ROSMAP | ENST00000545871 | 17837537 | 17837733 | hsa-miR-7153-5p | chrX:17837586-17837593 | 8mer-1a | chrX:17837569-17837593 | 145.00 | -16.05 |
ROSMAP | ENST00000360011 | 17837537 | 17837730 | hsa-miR-146a-5p | chrX:17837586-17837593 | 8mer-1a | chrX:17837569-17837593 | 145.00 | -16.05 |
ROSMAP | ENST00000545871 | 17837537 | 17837733 | hsa-miR-146a-5p | chrX:17837586-17837593 | 8mer-1a | chrX:17837569-17837593 | 145.00 | -16.05 |
ROSMAP | ENST00000360011 | 17837537 | 17837730 | hsa-miR-1275 | chrX:17837665-17837672 | 8mer-1a | chrX:17837662-17837683 | 163.00 | -20.40 |
ROSMAP | ENST00000545871 | 17837537 | 17837733 | hsa-miR-1275 | chrX:17837665-17837672 | 8mer-1a | chrX:17837662-17837683 | 163.00 | -20.40 |
ROSMAP | ENST00000360011 | 17837537 | 17837730 | hsa-miR-6840-3p | chrX:17837720-17837727 | 8mer-1a | chrX:17837706-17837727 | 140.00 | -21.18 |
ROSMAP | ENST00000545871 | 17837537 | 17837733 | hsa-miR-6840-3p | chrX:17837720-17837727 | 8mer-1a | chrX:17837706-17837727 | 140.00 | -21.18 |
ROSMAP | ENST00000360011 | 17837537 | 17837730 | hsa-miR-6845-3p | chrX:17837673-17837680 | 8mer-1a | chrX:17837670-17837695 | 157.00 | -27.23 |
ROSMAP | ENST00000545871 | 17837537 | 17837733 | hsa-miR-6845-3p | chrX:17837673-17837680 | 8mer-1a | chrX:17837670-17837695 | 157.00 | -27.23 |
ROSMAP | ENST00000360011 | 17837537 | 17837730 | hsa-miR-4665-5p | chrX:17837665-17837672 | 8mer-1a | chrX:17837662-17837683 | 163.00 | -20.40 |
ROSMAP | ENST00000545871 | 17837537 | 17837733 | hsa-miR-4665-5p | chrX:17837665-17837672 | 8mer-1a | chrX:17837662-17837683 | 163.00 | -20.40 |
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SNVs in the skipped exons for RAI2 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for RAI2 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RAI2 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for RAI2 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for RAI2 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAI2 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |