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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for RBBP9 |
 Gene summary |
| Gene information | Gene symbol | RBBP9 | Gene ID | 10741 |
| Gene name | RB binding protein 9, serine hydrolase | |
| Synonyms | BOG|RBBP10 | |
| Cytomap | 20p11.23 | |
| Type of gene | protein-coding | |
| Description | serine hydrolase RBBP9B5T overexpressed gene proteinRBBP-10RBBP-9putative hydrolase RBBP9retinoblastoma-binding protein 10retinoblastoma-binding protein 9retinoma-binding protein 9 | |
| Modification date | 20200313 | |
| UniProtAcc | O75884, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for RBBP9 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000089050
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000493184.5 | RBBP9-203:lncRNA:RBBP9 | 5.601567e+00 | 9.970163e-01 | 2.605674e-03 | 1.147741e-02 |
| TC | UP | ENST00000491835.1 | RBBP9-202:lncRNA:RBBP9 | 1.036185e+01 | 9.805603e-01 | 5.453907e-07 | 2.475149e-05 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for RBBP9 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_112781 | chr20 | 18489288:18489990:18490395:18490480:18493958:18494063 | 18490395:18490480 |
| exon_skip_128207 | chr20 | 18490395:18490480:18493958:18494063:18497069:18497174 | 18493958:18494063 |
| exon_skip_264068 | chr20 | 18489459:18489990:18490395:18490480:18493958:18494063 | 18490395:18490480 |
| exon_skip_67287 | chr20 | 18490395:18490480:18493958:18494063:18495838:18495880 | 18493958:18494063 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_69560 | Mayo_CB | 2.959494e-01 | 4.911667e-01 | -1.952173e-01 | 4.783753e-08 |
| exon_skip_69560 | Mayo_TC | 6.474390e-01 | 7.585246e-01 | -1.110856e-01 | 9.207769e-06 |
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Open reading frame (ORF) annotation in the exon skipping event for RBBP9 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000337227 | 18490395 | 18490480 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000337227 | 18490395 | 18490480 | Frame-shift |
| ENST00000337227 | 18493958 | 18494063 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for RBBP9 |
p-ENSG00000089050_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in RBBP9 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for RBBP9 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for RBBP9 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RBBP9 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for RBBP9 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM3 | exon_skip_69560 | 6.227217e-01 | 2.733645e-16 |
| CB | TRA2A | exon_skip_69560 | -5.965282e-01 | 9.278411e-15 |
| CB | NUP42 | exon_skip_69560 | 5.593993e-01 | 8.187042e-13 |
| CB | PABPC4 | exon_skip_69560 | 5.051985e-01 | 2.261171e-10 |
| HCC | RBM3 | exon_skip_69560 | 6.238516e-01 | 1.781933e-28 |
| PCC | RBM3 | exon_skip_69560 | 6.794780e-01 | 2.795926e-23 |
| TC | RBM3 | exon_skip_69560 | 6.497170e-01 | 1.654552e-18 |
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RelatedDrugs for RBBP9 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RBBP9 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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