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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CORIN |
 Gene summary |
| Gene information | Gene symbol | CORIN | Gene ID | 10699 |
| Gene name | corin, serine peptidase | |
| Synonyms | ATC2|CRN|Lrp4|PEE5|TMPRSS10 | |
| Cytomap | 4p12 | |
| Type of gene | protein-coding | |
| Description | atrial natriuretic peptide-converting enzymeheart-specific serine proteinase ATC2pro-ANP-convertasepro-ANP-converting enzymetransmembrane protease serine 10 | |
| Modification date | 20200327 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CORIN | GO:0016486 | peptide hormone processing | 10880574 |
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Gene structures and expression levels for CORIN |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000145244
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CORIN |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_134322 | chr4 | 47600214:47600347:47603397:47603668:47623571:47623745 | 47603397:47603668 |
| exon_skip_69681 | chr4 | 47665032:47665263:47674393:47674500:47677938:47678054 | 47674393:47674500 |
| exon_skip_95667 | chr4 | 47645081:47645194:47653553:47653660:47661711:47661856 | 47653553:47653660 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CORIN |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000273857 | 47603397 | 47603668 | Frame-shift |
| ENST00000273857 | 47653553 | 47653660 | In-frame |
| ENST00000273857 | 47674393 | 47674500 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CORIN |
p-ENSG00000145244_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000273857 | 4869 | 1042 | 47674393 | 47674500 | 1250 | 1356 | 416 | 452 |
| ENST00000273857 | 4869 | 1042 | 47653553 | 47653660 | 1736 | 1842 | 578 | 614 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y5Q5 | 416 | 452 | 1 | 1042 | Chain | ID=PRO_0000088673;Note=Atrial natriuretic peptide-converting enzyme |
| Q9Y5Q5 | 416 | 452 | 1 | 801 | Chain | ID=PRO_0000391765;Note=Atrial natriuretic peptide-converting enzyme%2C N-terminal propeptide;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9Y5Q5 | 416 | 452 | 165 | 801 | Chain | ID=PRO_0000417984;Note=Atrial natriuretic peptide-converting enzyme%2C 160 kDa soluble fragment;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9Y5Q5 | 416 | 452 | 428 | 801 | Chain | ID=PRO_0000417985;Note=Atrial natriuretic peptide-converting enzyme%2C 100 kDa soluble fragment;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9Y5Q5 | 416 | 452 | 450 | 573 | Domain | Note=FZ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00090 |
| Q9Y5Q5 | 416 | 452 | 446 | 446 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9Y5Q5 | 416 | 452 | 451 | 451 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9Y5Q5 | 416 | 452 | 427 | 427 | Mutagenesis | Note=Affects autocatalytic cleavage and production of Atrial natriuretic peptide-converting enzyme%2C 100 kDa soluble fragment. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21288900;Dbxref=PMID:21288900 |
| Q9Y5Q5 | 416 | 452 | 444 | 444 | Natural variant | ID=VAR_067796;Note=D->G;Dbxref=dbSNP:rs13105608 |
| Q9Y5Q5 | 416 | 452 | 427 | 428 | Site | Note=Cleavage%3B by autolysis |
| Q9Y5Q5 | 416 | 452 | 67 | 1042 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9Y5Q5 | 578 | 614 | 1 | 1042 | Chain | ID=PRO_0000088673;Note=Atrial natriuretic peptide-converting enzyme |
| Q9Y5Q5 | 578 | 614 | 1 | 801 | Chain | ID=PRO_0000391765;Note=Atrial natriuretic peptide-converting enzyme%2C N-terminal propeptide;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9Y5Q5 | 578 | 614 | 165 | 801 | Chain | ID=PRO_0000417984;Note=Atrial natriuretic peptide-converting enzyme%2C 160 kDa soluble fragment;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9Y5Q5 | 578 | 614 | 428 | 801 | Chain | ID=PRO_0000417985;Note=Atrial natriuretic peptide-converting enzyme%2C 100 kDa soluble fragment;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9Y5Q5 | 578 | 614 | 580 | 592 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9Y5Q5 | 578 | 614 | 587 | 605 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9Y5Q5 | 578 | 614 | 599 | 614 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9Y5Q5 | 578 | 614 | 579 | 614 | Domain | Note=LDL-receptor class A 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00124 |
| Q9Y5Q5 | 578 | 614 | 67 | 1042 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in CORIN |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CORIN |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CORIN |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CORIN |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CORIN |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for CORIN |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CORIN |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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