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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CCT6B |
 Gene summary |
| Gene information | Gene symbol | CCT6B | Gene ID | 10693 |
| Gene name | chaperonin containing TCP1 subunit 6B | |
| Synonyms | CCT-zeta-2|CCTZ-2|Cctz2|TCP-1-zeta-2|TSA303 | |
| Cytomap | 17q12 | |
| Type of gene | protein-coding | |
| Description | T-complex protein 1 subunit zeta-2chaperonin containing TCP1, subunit 6B (zeta 2)chaperonin-containing T-complex polypeptide 1, subunit 6Btestis-specific Tcp20testis-specific protein TSA303 | |
| Modification date | 20200313 | |
| UniProtAcc | J3KRI6, Q92526, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for CCT6B |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000132141
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000436961.7 | CCT6B-203:protein_coding:CCT6B | 1.328268e+01 | -8.602850e-01 | 6.869572e-03 | 2.553836e-02 |
| CB | DOWN | ENST00000421975.7 | CCT6B-202:protein_coding:CCT6B | 9.044042e+00 | -1.218624e+00 | 8.323790e-03 | 2.989643e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CCT6B |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_137770 | chr17 | 34954426:34954599:34958560:34958694:34959587:34959650 | 34958560:34958694 |
| exon_skip_190239 | chr17 | 34942559:34942643:34942796:34942906:34951950:34952053 | 34942796:34942906 |
| exon_skip_214025 | chr17 | 34942484:34942643:34942796:34942906:34951950:34952053 | 34942796:34942906 |
| exon_skip_274603 | chr17 | 34939183:34939330:34939617:34939713:34940539:34940621 | 34939617:34939713 |
| exon_skip_50313 | chr17 | 34954426:34954599:34959587:34959650:34961257:34961402 | 34959587:34959650 |
| exon_skip_55048 | chr17 | 34942796:34942906:34951950:34952053:34954426:34954599 | 34951950:34952053 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CCT6B |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000314144 | 34939617 | 34939713 | Frame-shift |
| ENST00000314144 | 34942796 | 34942906 | In-frame |
| ENST00000314144 | 34958560 | 34958694 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000314144 | 34942796 | 34942906 | In-frame |
| ENST00000314144 | 34958560 | 34958694 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000314144 | 34939617 | 34939713 | Frame-shift |
| ENST00000314144 | 34951950 | 34952053 | Frame-shift |
| ENST00000314144 | 34942796 | 34942906 | In-frame |
| ENST00000314144 | 34958560 | 34958694 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CCT6B |
p-ENSG00000132141_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000314144 | 1855 | 530 | 34958560 | 34958694 | 318 | 451 | 67 | 111 |
| ENST00000314144 | 1855 | 530 | 34942796 | 34942906 | 731 | 840 | 205 | 241 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000314144 | 1855 | 530 | 34958560 | 34958694 | 318 | 451 | 67 | 111 |
| ENST00000314144 | 1855 | 530 | 34942796 | 34942906 | 731 | 840 | 205 | 241 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000314144 | 1855 | 530 | 34958560 | 34958694 | 318 | 451 | 67 | 111 |
| ENST00000314144 | 1855 | 530 | 34942796 | 34942906 | 731 | 840 | 205 | 241 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q92526 | 67 | 111 | 68 | 112 | Alternative sequence | ID=VSP_043040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q92526 | 67 | 111 | 1 | 530 | Chain | ID=PRO_0000128363;Note=T-complex protein 1 subunit zeta-2 |
| Q92526 | 67 | 111 | 86 | 86 | Sequence conflict | Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q92526 | 67 | 111 | 94 | 94 | Sequence conflict | Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q92526 | 205 | 241 | 206 | 242 | Alternative sequence | ID=VSP_047129;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q92526 | 205 | 241 | 1 | 530 | Chain | ID=PRO_0000128363;Note=T-complex protein 1 subunit zeta-2 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q92526 | 67 | 111 | 68 | 112 | Alternative sequence | ID=VSP_043040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q92526 | 67 | 111 | 1 | 530 | Chain | ID=PRO_0000128363;Note=T-complex protein 1 subunit zeta-2 |
| Q92526 | 67 | 111 | 86 | 86 | Sequence conflict | Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q92526 | 67 | 111 | 94 | 94 | Sequence conflict | Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q92526 | 205 | 241 | 206 | 242 | Alternative sequence | ID=VSP_047129;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q92526 | 205 | 241 | 1 | 530 | Chain | ID=PRO_0000128363;Note=T-complex protein 1 subunit zeta-2 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q92526 | 67 | 111 | 68 | 112 | Alternative sequence | ID=VSP_043040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q92526 | 67 | 111 | 1 | 530 | Chain | ID=PRO_0000128363;Note=T-complex protein 1 subunit zeta-2 |
| Q92526 | 67 | 111 | 86 | 86 | Sequence conflict | Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q92526 | 67 | 111 | 94 | 94 | Sequence conflict | Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q92526 | 205 | 241 | 206 | 242 | Alternative sequence | ID=VSP_047129;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q92526 | 205 | 241 | 1 | 530 | Chain | ID=PRO_0000128363;Note=T-complex protein 1 subunit zeta-2 |
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3'-UTR located exon skipping events that lost miRNA binding sites in CCT6B |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CCT6B |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CCT6B |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CCT6B |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CCT6B |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for CCT6B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CCT6B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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