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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TRIM16 |
 Gene summary |
| Gene information | Gene symbol | TRIM16 | Gene ID | 10626 |
| Gene name | tripartite motif containing 16 | |
| Synonyms | EBBP | |
| Cytomap | 17p12 | |
| Type of gene | protein-coding | |
| Description | tripartite motif-containing protein 16E3 ubiquitin-protein ligase TRIM16estrogen-responsive B box protein | |
| Modification date | 20200313 | |
| UniProtAcc | B3KP96, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TRIM16 | GO:0043966 | histone H3 acetylation | 19147277 |
| TRIM16 | GO:0043967 | histone H4 acetylation | 16636064 |
| TRIM16 | GO:0045618 | positive regulation of keratinocyte differentiation | 11919186 |
| TRIM16 | GO:0045893 | positive regulation of transcription, DNA-templated | 16636064|19147277 |
| TRIM16 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway | 16636064 |
| TRIM16 | GO:0060416 | response to growth hormone | 11919186 |
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Gene structures and expression levels for TRIM16 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000221926
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000336708.11 | TRIM16-201:protein_coding:TRIM16 | 2.704414e+01 | 1.015992e+00 | 5.032751e-03 | 4.594018e-02 |
| CB | UP | ENST00000336708.11 | TRIM16-201:protein_coding:TRIM16 | 6.508071e+01 | 9.906344e-01 | 8.375727e-06 | 9.098319e-05 |
| CB | UP | ENST00000580110.5 | TRIM16-219:protein_coding:TRIM16 | 2.376828e+00 | 1.434203e+00 | 1.104199e-03 | 5.613279e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TRIM16 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_163799 | chr17 | 15680865:15680953:15682854:15682964:15683036:15683157 | 15682854:15682964 |
| exon_skip_175385 | chr17 | 15680865:15680953:15682854:15682951:15683036:15683147 | 15682854:15682951 |
| exon_skip_184782 | chr17 | 15651837:15651946:15677176:15677280:15680865:15680918 | 15677176:15677280 |
| exon_skip_195655 | chr17 | 15680865:15680953:15681051:15681222:15683036:15683157 | 15681051:15681222 |
| exon_skip_219593 | chr17 | 15642721:15642816:15651091:15651946:15677176:15677277 | 15651091:15651946 |
| exon_skip_220041 | chr17 | 15680865:15680953:15682854:15682951:15683036:15683157 | 15682854:15682951 |
| exon_skip_220496 | chr17 | 15681088:15681222:15682854:15682951:15683036:15683157 | 15682854:15682951 |
| exon_skip_249756 | chr17 | 15642721:15642816:15658802:15658876:15680865:15680953 | 15658802:15658876 |
| exon_skip_256946 | chr17 | 15680865:15680953:15682854:15682964:15683036:15683147 | 15682854:15682964 |
| exon_skip_269358 | chr17 | 15680865:15680953:15682861:15682951:15683036:15683157 | 15682861:15682951 |
| exon_skip_278270 | chr17 | 15631619:15631714:15632509:15632674:15636036:15636269 | 15632509:15632674 |
| exon_skip_282707 | chr17 | 15651837:15651946:15658802:15658876:15680865:15680930 | 15658802:15658876 |
| exon_skip_282783 | chr17 | 15642721:15642816:15651091:15651946:15677176:15677280 | 15651091:15651946 |
| exon_skip_295231 | chr17 | 15651837:15651946:15658802:15658876:15680865:15680918 | 15658802:15658876 |
| exon_skip_48266 | chr17 | 15677176:15677280:15677575:15677721:15680865:15680953 | 15677575:15677721 |
| exon_skip_86323 | chr17 | 15677176:15677280:15677575:15677721:15680865:15680918 | 15677575:15677721 |
| exon_skip_93320 | chr17 | 15680865:15680953:15681051:15681222:15683036:15683147 | 15681051:15681222 |
| exon_skip_95790 | chr17 | 15680865:15680953:15682861:15682951:15683036:15683147 | 15682861:15682951 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TRIM16 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000336708 | 15651091 | 15651946 | 3UTR-3CDS |
| ENST00000578237 | 15651091 | 15651946 | 3UTR-3CDS |
| ENST00000336708 | 15677176 | 15677280 | 3UTR-3UTR |
| ENST00000578237 | 15677176 | 15677280 | 3UTR-3UTR |
| ENST00000578237 | 15682854 | 15682951 | 3UTR-3UTR |
| ENST00000336708 | 15632509 | 15632674 | Frame-shift |
| ENST00000578237 | 15632509 | 15632674 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000578237 | 15682854 | 15682951 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000336708 | 15651091 | 15651946 | 3UTR-3CDS |
| ENST00000578237 | 15651091 | 15651946 | 3UTR-3CDS |
| ENST00000336708 | 15677176 | 15677280 | 3UTR-3UTR |
| ENST00000578237 | 15677176 | 15677280 | 3UTR-3UTR |
| ENST00000578237 | 15682854 | 15682951 | 3UTR-3UTR |
| ENST00000336708 | 15632509 | 15632674 | Frame-shift |
| ENST00000578237 | 15632509 | 15632674 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for TRIM16 |
p-ENSG00000221926_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in TRIM16 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000578237 | 15682854 | 15682951 | hsa-miR-6072 | chr17:15682890-15682897 | 8mer-1a | chr17:15682880-15682899 | 149.00 | -19.81 |
| Mayo | ENST00000578237 | 15682854 | 15682951 | hsa-miR-670-3p | chr17:15682892-15682899 | 8mer-1a | chr17:15682880-15682899 | 149.00 | -19.81 |
| Mayo | ENST00000578237 | 15677176 | 15677280 | hsa-miR-4722-5p | chr17:15677204-15677211 | 8mer-1a | chr17:15677187-15677211 | 167.00 | -34.39 |
| Mayo | ENST00000578237 | 15682854 | 15682951 | hsa-miR-6867-5p | chr17:15682931-15682938 | 8mer-1a | chr17:15682916-15682938 | 149.00 | -20.81 |
| Mayo | ENST00000578237 | 15682854 | 15682951 | hsa-miR-10401-5p | chr17:15682929-15682936 | 8mer-1a | chr17:15682918-15682936 | 152.00 | -24.08 |
| Mayo | ENST00000578237 | 15682854 | 15682951 | hsa-miR-6891-3p | chr17:15682890-15682897 | 8mer-1a | chr17:15682880-15682899 | 149.00 | -19.81 |
| MSBB | ENST00000578237 | 15682854 | 15682951 | hsa-miR-6072 | chr17:15682890-15682897 | 8mer-1a | chr17:15682880-15682899 | 149.00 | -19.81 |
| MSBB | ENST00000578237 | 15682854 | 15682951 | hsa-miR-670-3p | chr17:15682892-15682899 | 8mer-1a | chr17:15682880-15682899 | 149.00 | -19.81 |
| MSBB | ENST00000578237 | 15682854 | 15682951 | hsa-miR-6867-5p | chr17:15682931-15682938 | 8mer-1a | chr17:15682916-15682938 | 149.00 | -20.81 |
| MSBB | ENST00000578237 | 15682854 | 15682951 | hsa-miR-10401-5p | chr17:15682929-15682936 | 8mer-1a | chr17:15682918-15682936 | 152.00 | -24.08 |
| MSBB | ENST00000578237 | 15682854 | 15682951 | hsa-miR-6891-3p | chr17:15682890-15682897 | 8mer-1a | chr17:15682880-15682899 | 149.00 | -19.81 |
| ROSMAP | ENST00000578237 | 15682854 | 15682951 | hsa-miR-6072 | chr17:15682890-15682897 | 8mer-1a | chr17:15682880-15682899 | 149.00 | -19.81 |
| ROSMAP | ENST00000578237 | 15682854 | 15682951 | hsa-miR-670-3p | chr17:15682892-15682899 | 8mer-1a | chr17:15682880-15682899 | 149.00 | -19.81 |
| ROSMAP | ENST00000578237 | 15677176 | 15677280 | hsa-miR-4722-5p | chr17:15677204-15677211 | 8mer-1a | chr17:15677187-15677211 | 167.00 | -34.39 |
| ROSMAP | ENST00000578237 | 15682854 | 15682951 | hsa-miR-6867-5p | chr17:15682931-15682938 | 8mer-1a | chr17:15682916-15682938 | 149.00 | -20.81 |
| ROSMAP | ENST00000578237 | 15682854 | 15682951 | hsa-miR-10401-5p | chr17:15682929-15682936 | 8mer-1a | chr17:15682918-15682936 | 152.00 | -24.08 |
| ROSMAP | ENST00000578237 | 15682854 | 15682951 | hsa-miR-6891-3p | chr17:15682890-15682897 | 8mer-1a | chr17:15682880-15682899 | 149.00 | -19.81 |
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SNVs in the skipped exons for TRIM16 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TRIM16 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TRIM16 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TRIM16 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for TRIM16 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRIM16 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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