ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for SORBS1

Gene summary

Gene information	Gene symbol	SORBS1
	Gene ID	10580
	Gene name	sorbin and SH3 domain containing 1
	Synonyms	CAP\|FLAF2\|R85FL\|SH3D5\|SH3P12\|SORB1
	Cytomap	10q24.1
	Type of gene	protein-coding
	Description	sorbin and SH3 domain-containing protein 1Fas-ligand associated factor 2SH3 domain protein 5c-Cbl associated proteinponsin
	Modification date	20200313
	UniProtAcc	A0A0U1RQI5, A0A3B3IRR9, A0A3B3IRW8, A0A3B3IT56, D3DR43, Q5T925, Q9BX66, S4R303, S4R406,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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Gene structures and expression levels for SORBS1

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000095637

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
STG	UP	ENST00000354106.7	SORBS1-203:protein_coding:SORBS1	1.149267e+02	9.758229e-01	3.059285e-05	5.655152e-03
PG	UP	ENST00000634504.1	SORBS1-220:protein_coding:SORBS1	2.663657e+02	1.063375e+00	2.277145e-13	5.437638e-10
PG	UP	ENST00000354106.7	SORBS1-203:protein_coding:SORBS1	1.872697e+02	1.055806e+00	2.710563e-11	2.446961e-08
PG	UP	ENST00000371249.6	SORBS1-212:protein_coding:SORBS1	1.342841e+02	2.051301e+00	2.762511e-04	5.777546e-03
TC	UP	ENST00000306402.10	SORBS1-202:protein_coding:SORBS1	2.002919e+03	8.498800e-01	6.181235e-14	3.288412e-11
TC	UP	ENST00000354106.7	SORBS1-203:protein_coding:SORBS1	2.571938e+02	9.530863e-01	1.189047e-12	4.292928e-10
TC	UP	ENST00000371249.6	SORBS1-212:protein_coding:SORBS1	1.772281e+02	1.747313e+00	5.679831e-06	1.647259e-04

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for SORBS1

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_101915	chr10	95367650:95367699:95371326:95371427:95371984:95372049	95371326:95371427
exon_skip_102016	chr10	95367650:95367699:95371326:95371427:95375973:95376056	95371326:95371427
exon_skip_103238	chr10	95399017:95399189:95406118:95406147:95410633:95410719	95406118:95406147
exon_skip_108322	chr10	95410633:95410777:95414494:95414862:95415469:95415785	95414494:95414862
exon_skip_109450	chr10	95346406:95346452:95351216:95351376:95354882:95354967	95351216:95351376
exon_skip_11472	chr10	95322746:95322805:95336521:95337294:95339133:95339327	95336521:95337294
exon_skip_123417	chr10	95321965:95322021:95322746:95322805:95339133:95339327	95322746:95322805
exon_skip_12479	chr10	95410633:95410777:95414494:95414655:95421961:95422073	95414494:95414655
exon_skip_126073	chr10	95410633:95410777:95414494:95414862:95415469:95416185	95414494:95414862
exon_skip_129649	chr10	95410633:95410777:95415469:95416185:95421961:95422072	95415469:95416185
exon_skip_135248	chr10	95341674:95341678:95346406:95346452:95351209:95351376	95346406:95346452
exon_skip_138926	chr10	95384238:95384285:95386991:95387119:95395001:95395073	95386991:95387119
exon_skip_141121	chr10	95421961:95422073:95422190:95422216:95432448:95432576	95422190:95422216
exon_skip_147647	chr10	95410633:95410777:95414494:95414862:95421961:95422072	95414494:95414862
exon_skip_154300	chr10	95346406:95346452:95351209:95351376:95354882:95354967	95351209:95351376
exon_skip_158407	chr10	95432448:95432576:95434622:95434717:95437490:95437555	95434622:95434717
exon_skip_164577	chr10	95371326:95371427:95375973:95376056:95381685:95381799	95375973:95376056
exon_skip_165877	chr10	95346406:95346452:95351216:95351376:95354882:95354961	95351216:95351376
exon_skip_171618	chr10	95414494:95414862:95415469:95416185:95421961:95422073	95415469:95416185
exon_skip_172811	chr10	95341674:95341678:95346406:95346452:95354882:95354961	95346406:95346452
exon_skip_176408	chr10	95321965:95322021:95336521:95336805:95339133:95339327	95336521:95336805
exon_skip_18631	chr10	95410633:95410777:95414494:95414862:95415469:95416149	95414494:95414862
exon_skip_189459	chr10	95367650:95367699:95375973:95376056:95381685:95381799	95375973:95376056
exon_skip_195627	chr10	95321963:95322021:95336521:95337294:95339133:95339327	95336521:95337294
exon_skip_196568	chr10	95321963:95322021:95322746:95322805:95336521:95336805	95322746:95322805
exon_skip_199765	chr10	95432502:95432576:95434622:95434717:95437490:95437555	95434622:95434717
exon_skip_202978	chr10	95384238:95384285:95386991:95387119:95395001:95395063	95386991:95387119
exon_skip_203712	chr10	95321963:95322021:95336521:95336805:95339133:95339327	95336521:95336805
exon_skip_209242	chr10	95354882:95354967:95355627:95357105:95357631:95357777	95355627:95357105
exon_skip_211441	chr10	95421961:95422073:95422190:95422216:95432448:95432468	95422190:95422216
exon_skip_215667	chr10	95399017:95399189:95406118:95406147:95410633:95410777	95406118:95406147
exon_skip_22734	chr10	95341674:95341678:95346406:95346452:95354882:95354967	95346406:95346452
exon_skip_228726	chr10	95321963:95322021:95322746:95322805:95339133:95339327	95322746:95322805
exon_skip_230424	chr10	95386991:95387119:95395001:95395075:95397220:95397283	95395001:95395075
exon_skip_238760	chr10	95384238:95384285:95394611:95394673:95395001:95395063	95394611:95394673
exon_skip_248216	chr10	95341285:95341410:95341564:95341678:95346406:95346452	95341564:95341678
exon_skip_248626	chr10	95318320:95318432:95321963:95322021:95339133:95339327	95321963:95322021
exon_skip_253064	chr10	95318320:95318432:95321963:95322153:95339133:95339327	95321963:95322153
exon_skip_253982	chr10	95384051:95384114:95384238:95384285:95397220:95397283	95384238:95384285
exon_skip_256073	chr10	95414744:95414862:95415469:95416185:95421961:95422073	95415469:95416185
exon_skip_264227	chr10	95354882:95354967:95355627:95357105:95357631:95357803	95355627:95357105
exon_skip_272794	chr10	95321964:95322021:95336521:95337294:95339133:95339327	95336521:95337294
exon_skip_274204	chr10	95346406:95346452:95351209:95351376:95354882:95354961	95351209:95351376
exon_skip_275415	chr10	95321964:95322021:95336521:95336805:95339133:95339327	95336521:95336805
exon_skip_278932	chr10	95371984:95372049:95375973:95376056:95381685:95381799	95375973:95376056
exon_skip_28336	chr10	95367650:95367699:95371984:95372049:95375973:95376056	95371984:95372049
exon_skip_28742	chr10	95315059:95315126:95318320:95318432:95321963:95322021	95318320:95318432
exon_skip_289833	chr10	95321963:95322021:95322746:95322805:95336521:95337294	95322746:95322805
exon_skip_292122	chr10	95321965:95322021:95336521:95337294:95339133:95339327	95336521:95337294
exon_skip_293592	chr10	95384238:95384285:95395001:95395075:95397220:95397283	95395001:95395075
exon_skip_294830	chr10	95371326:95371427:95371984:95372049:95375973:95376056	95371984:95372049
exon_skip_32799	chr10	95394611:95394673:95395001:95395075:95397220:95397283	95395001:95395075
exon_skip_34297	chr10	95321964:95322021:95322746:95322805:95336521:95336805	95322746:95322805
exon_skip_35904	chr10	95410633:95410777:95415469:95416185:95421961:95422073	95415469:95416185
exon_skip_39477	chr10	95399017:95399189:95410633:95410777:95421961:95422073	95410633:95410777
exon_skip_42290	chr10	95410633:95410777:95414494:95414655:95421961:95422072	95414494:95414655
exon_skip_48661	chr10	95441126:95441180:95491035:95491120:95561320:95561355	95491035:95491120
exon_skip_59154	chr10	95410633:95410777:95414494:95414862:95421961:95422073	95414494:95414862
exon_skip_59635	chr10	95414830:95414862:95415469:95416185:95421961:95422073	95415469:95416185
exon_skip_62369	chr10	95399017:95399189:95406118:95406147:95410633:95410769	95406118:95406147
exon_skip_63566	chr10	95384238:95384285:95394611:95394673:95395001:95395075	95394611:95394673
exon_skip_68438	chr10	95354882:95354967:95355627:95357105:95357631:95357801	95355627:95357105
exon_skip_80618	chr10	95357631:95357803:95367650:95367699:95381685:95381799	95367650:95367699
exon_skip_8417	chr10	95384238:95384285:95386991:95387119:95395001:95395075	95386991:95387119
exon_skip_84542	chr10	95321964:95322021:95322746:95322805:95339133:95339327	95322746:95322805
exon_skip_96781	chr10	95321965:95322021:95322746:95322805:95336521:95336805	95322746:95322805
exon_skip_98963	chr10	95384238:95384285:95394611:95394673:95395001:95395073	95394611:95394673

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information	Tissue type	Avg(PSIs) in AD	Avg(PSIs) in control	Difference (PSI)	Adj. p-value
exon_skip_158407	ROSMAP_DLPFC	4.554673e-01	3.290598e-01	1.264075e-01	1.297682e-08
exon_skip_102016	MSBB_STG	3.088235e-01	4.208333e-01	-1.120098e-01	1.383912e-02
exon_skip_158407	MSBB_STG	2.795588e-01	1.512500e-01	1.283088e-01	6.775503e-04
exon_skip_102016	MSBB_PG	1.676159e-01	3.548276e-01	-1.872117e-01	2.010780e-09
exon_skip_293592	MSBB_PG	5.014286e-01	3.433333e-01	1.580952e-01	1.525726e-07
exon_skip_158407	MSBB_PG	4.067376e-01	2.491228e-01	1.576148e-01	2.111467e-08

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Open reading frame (ORF) annotation in the exon skipping event for SORBS1

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000371247	95491035	95491120	3UTR-3UTR
ENST00000361941	95341564	95341678	Frame-shift
ENST00000371247	95341564	95341678	Frame-shift
ENST00000361941	95346406	95346452	Frame-shift
ENST00000371247	95346406	95346452	Frame-shift
ENST00000361941	95336521	95337294	In-frame
ENST00000371247	95336521	95337294	In-frame
ENST00000361941	95351209	95351376	In-frame
ENST00000371247	95351209	95351376	In-frame
ENST00000361941	95371326	95371427	In-frame
ENST00000371247	95371326	95371427	In-frame
ENST00000361941	95371984	95372049	In-frame
ENST00000371247	95371984	95372049	In-frame
ENST00000361941	95394611	95394673	In-frame
ENST00000371247	95394611	95394673	In-frame
ENST00000361941	95395001	95395075	In-frame
ENST00000371247	95395001	95395075	In-frame
ENST00000361941	95406118	95406147	In-frame
ENST00000371247	95406118	95406147	In-frame
ENST00000361941	95414494	95414862	In-frame
ENST00000371247	95414494	95414862	In-frame
ENST00000361941	95422190	95422216	In-frame
ENST00000371247	95422190	95422216	In-frame
ENST00000361941	95434622	95434717	In-frame
ENST00000371247	95434622	95434717	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000371247	95491035	95491120	3UTR-3UTR
ENST00000361941	95318320	95318432	Frame-shift
ENST00000371247	95318320	95318432	Frame-shift
ENST00000361941	95341564	95341678	Frame-shift
ENST00000371247	95341564	95341678	Frame-shift
ENST00000361941	95336521	95337294	In-frame
ENST00000371247	95336521	95337294	In-frame
ENST00000361941	95351209	95351376	In-frame
ENST00000371247	95351209	95351376	In-frame
ENST00000361941	95371326	95371427	In-frame
ENST00000371247	95371326	95371427	In-frame
ENST00000361941	95371984	95372049	In-frame
ENST00000371247	95371984	95372049	In-frame
ENST00000361941	95394611	95394673	In-frame
ENST00000371247	95394611	95394673	In-frame
ENST00000361941	95395001	95395075	In-frame
ENST00000371247	95395001	95395075	In-frame
ENST00000361941	95406118	95406147	In-frame
ENST00000371247	95406118	95406147	In-frame
ENST00000361941	95414494	95414862	In-frame
ENST00000371247	95414494	95414862	In-frame
ENST00000361941	95422190	95422216	In-frame
ENST00000371247	95422190	95422216	In-frame
ENST00000361941	95434622	95434717	In-frame
ENST00000371247	95434622	95434717	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000371247	95491035	95491120	3UTR-3UTR
ENST00000361941	95318320	95318432	Frame-shift
ENST00000371247	95318320	95318432	Frame-shift
ENST00000361941	95341564	95341678	Frame-shift
ENST00000371247	95341564	95341678	Frame-shift
ENST00000361941	95346406	95346452	Frame-shift
ENST00000371247	95346406	95346452	Frame-shift
ENST00000361941	95336521	95337294	In-frame
ENST00000371247	95336521	95337294	In-frame
ENST00000361941	95351209	95351376	In-frame
ENST00000371247	95351209	95351376	In-frame
ENST00000361941	95371326	95371427	In-frame
ENST00000371247	95371326	95371427	In-frame
ENST00000361941	95371984	95372049	In-frame
ENST00000371247	95371984	95372049	In-frame
ENST00000361941	95375973	95376056	In-frame
ENST00000371247	95375973	95376056	In-frame
ENST00000361941	95394611	95394673	In-frame
ENST00000371247	95394611	95394673	In-frame
ENST00000361941	95406118	95406147	In-frame
ENST00000371247	95406118	95406147	In-frame
ENST00000361941	95414494	95414862	In-frame
ENST00000371247	95414494	95414862	In-frame
ENST00000361941	95422190	95422216	In-frame
ENST00000371247	95422190	95422216	In-frame
ENST00000361941	95434622	95434717	In-frame
ENST00000371247	95434622	95434717	In-frame

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Infer the effects of exon skipping event on protein functional features for SORBS1

p-ENSG00000095637_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000361941	3957	1292	95434622	95434717	104	198	25	57
ENST00000371247	7371	1292	95434622	95434717	267	361	25	57
ENST00000361941	3957	1292	95414494	95414862	469	836	147	269
ENST00000371247	7371	1292	95414494	95414862	632	999	147	269
ENST00000361941	3957	1292	95406118	95406147	983	1011	318	328
ENST00000371247	7371	1292	95406118	95406147	1146	1174	318	328
ENST00000361941	3957	1292	95395001	95395075	1250	1323	407	432
ENST00000371247	7371	1292	95395001	95395075	1413	1486	407	432
ENST00000361941	3957	1292	95394611	95394673	1325	1386	432	453
ENST00000371247	7371	1292	95394611	95394673	1488	1549	432	453
ENST00000361941	3957	1292	95371984	95372049	1765	1829	579	600
ENST00000371247	7371	1292	95371984	95372049	1928	1992	579	600
ENST00000361941	3957	1292	95371326	95371427	1831	1931	601	634
ENST00000371247	7371	1292	95371326	95371427	1994	2094	601	634
ENST00000361941	3957	1292	95351209	95351376	2242	2408	738	793
ENST00000371247	7371	1292	95351209	95351376	2405	2571	738	793
ENST00000361941	3957	1292	95336521	95337294	2893	3665	955	1212
ENST00000371247	7371	1292	95336521	95337294	3056	3828	955	1212

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000361941	3957	1292	95434622	95434717	104	198	25	57
ENST00000371247	7371	1292	95434622	95434717	267	361	25	57
ENST00000361941	3957	1292	95414494	95414862	469	836	147	269
ENST00000371247	7371	1292	95414494	95414862	632	999	147	269
ENST00000361941	3957	1292	95406118	95406147	983	1011	318	328
ENST00000371247	7371	1292	95406118	95406147	1146	1174	318	328
ENST00000361941	3957	1292	95395001	95395075	1250	1323	407	432
ENST00000371247	7371	1292	95395001	95395075	1413	1486	407	432
ENST00000361941	3957	1292	95394611	95394673	1325	1386	432	453
ENST00000371247	7371	1292	95394611	95394673	1488	1549	432	453
ENST00000361941	3957	1292	95371984	95372049	1765	1829	579	600
ENST00000371247	7371	1292	95371984	95372049	1928	1992	579	600
ENST00000361941	3957	1292	95371326	95371427	1831	1931	601	634
ENST00000371247	7371	1292	95371326	95371427	1994	2094	601	634
ENST00000361941	3957	1292	95351209	95351376	2242	2408	738	793
ENST00000371247	7371	1292	95351209	95351376	2405	2571	738	793
ENST00000361941	3957	1292	95336521	95337294	2893	3665	955	1212
ENST00000371247	7371	1292	95336521	95337294	3056	3828	955	1212

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000361941	3957	1292	95434622	95434717	104	198	25	57
ENST00000371247	7371	1292	95434622	95434717	267	361	25	57
ENST00000361941	3957	1292	95414494	95414862	469	836	147	269
ENST00000371247	7371	1292	95414494	95414862	632	999	147	269
ENST00000361941	3957	1292	95406118	95406147	983	1011	318	328
ENST00000371247	7371	1292	95406118	95406147	1146	1174	318	328
ENST00000361941	3957	1292	95394611	95394673	1325	1386	432	453
ENST00000371247	7371	1292	95394611	95394673	1488	1549	432	453
ENST00000361941	3957	1292	95375973	95376056	1681	1763	551	578
ENST00000371247	7371	1292	95375973	95376056	1844	1926	551	578
ENST00000361941	3957	1292	95371984	95372049	1765	1829	579	600
ENST00000371247	7371	1292	95371984	95372049	1928	1992	579	600
ENST00000361941	3957	1292	95371326	95371427	1831	1931	601	634
ENST00000371247	7371	1292	95371326	95371427	1994	2094	601	634
ENST00000361941	3957	1292	95351209	95351376	2242	2408	738	793
ENST00000371247	7371	1292	95351209	95351376	2405	2571	738	793
ENST00000361941	3957	1292	95336521	95337294	2893	3665	955	1212
ENST00000371247	7371	1292	95336521	95337294	3056	3828	955	1212

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q9BX66	25	57	26	57	Alternative sequence	ID=VSP_050895;Note=In isoform 4%2C isoform 7%2C isoform 8%2C isoform 10 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11230166,ECO:0000303\|PubMed:11371513,ECO:0000303\|PubMed:11374898,ECO:
Q9BX66	25	57	26	57	Alternative sequence	ID=VSP_050895;Note=In isoform 4%2C isoform 7%2C isoform 8%2C isoform 10 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11230166,ECO:0000303\|PubMed:11371513,ECO:0000303\|PubMed:11374898,ECO:
Q9BX66	25	57	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	25	57	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	147	269	147	215	Alternative sequence	ID=VSP_050898;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	147	269	147	215	Alternative sequence	ID=VSP_050898;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	147	269	148	270	Alternative sequence	ID=VSP_050899;Note=In isoform 4%2C isoform 6%2C isoform 8%2C isoform 9 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718198,ECO:0000303\|PubMed:11371513,ECO:0000303\|PubMed:11
Q9BX66	147	269	148	270	Alternative sequence	ID=VSP_050899;Note=In isoform 4%2C isoform 6%2C isoform 8%2C isoform 9 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718198,ECO:0000303\|PubMed:11371513,ECO:0000303\|PubMed:11
Q9BX66	147	269	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	147	269	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	147	269	242	242	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24275569;Dbxref=PMID:24275569
Q9BX66	147	269	242	242	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24275569;Dbxref=PMID:24275569
Q9BX66	147	269	259	259	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24275569;Dbxref=PMID:24275569
Q9BX66	147	269	259	259	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24275569;Dbxref=PMID:24275569
Q9BX66	147	269	175	175	Natural variant	ID=VAR_047653;Note=G->V;Dbxref=dbSNP:rs7081076
Q9BX66	147	269	175	175	Natural variant	ID=VAR_047653;Note=G->V;Dbxref=dbSNP:rs7081076
Q9BX66	147	269	195	195	Natural variant	ID=VAR_035661;Note=In a breast cancer sample%3B somatic mutation. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q9BX66	147	269	195	195	Natural variant	ID=VAR_035661;Note=In a breast cancer sample%3B somatic mutation. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q9BX66	147	269	237	237	Natural variant	ID=VAR_019654;Note=Has a protective role in both obesity and diabetes. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11532984;Dbxref=dbSNP:rs2281939,PMID:11532984
Q9BX66	147	269	237	237	Natural variant	ID=VAR_019654;Note=Has a protective role in both obesity and diabetes. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11532984;Dbxref=dbSNP:rs2281939,PMID:11532984
Q9BX66	147	269	226	228	Sequence conflict	Note=RAS->SAC;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	147	269	226	228	Sequence conflict	Note=RAS->SAC;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	147	269	264	264	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	147	269	264	264	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	318	328	319	328	Alternative sequence	ID=VSP_041193;Note=In isoform 12. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	318	328	319	328	Alternative sequence	ID=VSP_041193;Note=In isoform 12. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	318	328	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	318	328	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	407	432	408	453	Alternative sequence	ID=VSP_050900;Note=In isoform 3%2C isoform 4%2C isoform 7%2C isoform 8%2C isoform 9%2C isoform 10%2C isoform 11 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718
Q9BX66	407	432	408	453	Alternative sequence	ID=VSP_050900;Note=In isoform 3%2C isoform 4%2C isoform 7%2C isoform 8%2C isoform 9%2C isoform 10%2C isoform 11 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718
Q9BX66	407	432	431	451	Alternative sequence	ID=VSP_050901;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11371513,ECO:0000303\|PubMed:11374898,ECO:0000303\|PubMed:11532984;Dbxref=PMID:11371513,PMID:11374898,PMID:11532984
Q9BX66	407	432	431	451	Alternative sequence	ID=VSP_050901;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11371513,ECO:0000303\|PubMed:11374898,ECO:0000303\|PubMed:11532984;Dbxref=PMID:11371513,PMID:11374898,PMID:11532984
Q9BX66	407	432	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	407	432	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	407	432	366	469	Domain	Note=SoHo;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00195
Q9BX66	407	432	366	469	Domain	Note=SoHo;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00195
Q9BX66	432	453	408	453	Alternative sequence	ID=VSP_050900;Note=In isoform 3%2C isoform 4%2C isoform 7%2C isoform 8%2C isoform 9%2C isoform 10%2C isoform 11 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718
Q9BX66	432	453	408	453	Alternative sequence	ID=VSP_050900;Note=In isoform 3%2C isoform 4%2C isoform 7%2C isoform 8%2C isoform 9%2C isoform 10%2C isoform 11 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718
Q9BX66	432	453	431	451	Alternative sequence	ID=VSP_050901;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11371513,ECO:0000303\|PubMed:11374898,ECO:0000303\|PubMed:11532984;Dbxref=PMID:11371513,PMID:11374898,PMID:11532984
Q9BX66	432	453	431	451	Alternative sequence	ID=VSP_050901;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11371513,ECO:0000303\|PubMed:11374898,ECO:0000303\|PubMed:11532984;Dbxref=PMID:11371513,PMID:11374898,PMID:11532984
Q9BX66	432	453	434	453	Alternative sequence	ID=VSP_050902;Note=In isoform 2. DNPYTPTYQFPASTPSPKSE->TKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVAGTA;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	432	453	434	453	Alternative sequence	ID=VSP_050902;Note=In isoform 2. DNPYTPTYQFPASTPSPKSE->TKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVAGTA;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	432	453	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	432	453	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	432	453	366	469	Domain	Note=SoHo;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00195
Q9BX66	432	453	366	469	Domain	Note=SoHo;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00195
Q9BX66	579	600	552	635	Alternative sequence	ID=VSP_050903;Note=In isoform 4%2C isoform 7%2C isoform 9 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718198,ECO:0000303\|PubMed:11230166,ECO:0000303\|PubMed:11374898,ECO:0000303\|PubMed
Q9BX66	579	600	552	635	Alternative sequence	ID=VSP_050903;Note=In isoform 4%2C isoform 7%2C isoform 9 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718198,ECO:0000303\|PubMed:11230166,ECO:0000303\|PubMed:11374898,ECO:0000303\|PubMed
Q9BX66	579	600	580	635	Alternative sequence	ID=VSP_050905;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:12504111;Dbxref=PMID:12504111
Q9BX66	579	600	580	635	Alternative sequence	ID=VSP_050905;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:12504111;Dbxref=PMID:12504111
Q9BX66	579	600	580	601	Alternative sequence	ID=VSP_050904;Note=In isoform 8 and isoform 12. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11371513;Dbxref=PMID:11371513
Q9BX66	579	600	580	601	Alternative sequence	ID=VSP_050904;Note=In isoform 8 and isoform 12. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11371513;Dbxref=PMID:11371513
Q9BX66	579	600	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	579	600	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	601	634	552	635	Alternative sequence	ID=VSP_050903;Note=In isoform 4%2C isoform 7%2C isoform 9 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718198,ECO:0000303\|PubMed:11230166,ECO:0000303\|PubMed:11374898,ECO:0000303\|PubMed
Q9BX66	601	634	552	635	Alternative sequence	ID=VSP_050903;Note=In isoform 4%2C isoform 7%2C isoform 9 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718198,ECO:0000303\|PubMed:11230166,ECO:0000303\|PubMed:11374898,ECO:0000303\|PubMed
Q9BX66	601	634	580	635	Alternative sequence	ID=VSP_050905;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:12504111;Dbxref=PMID:12504111
Q9BX66	601	634	580	635	Alternative sequence	ID=VSP_050905;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:12504111;Dbxref=PMID:12504111
Q9BX66	601	634	580	601	Alternative sequence	ID=VSP_050904;Note=In isoform 8 and isoform 12. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11371513;Dbxref=PMID:11371513
Q9BX66	601	634	580	601	Alternative sequence	ID=VSP_050904;Note=In isoform 8 and isoform 12. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11371513;Dbxref=PMID:11371513
Q9BX66	601	634	602	635	Alternative sequence	ID=VSP_050906;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	601	634	602	635	Alternative sequence	ID=VSP_050906;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	601	634	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	601	634	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	601	634	609	609	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q62417
Q9BX66	601	634	609	609	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q62417
Q9BX66	601	634	607	607	Sequence conflict	Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	601	634	607	607	Sequence conflict	Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	601	634	610	610	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	601	634	610	610	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	738	793	738	793	Alternative sequence	ID=VSP_050907;Note=In isoform 4 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11230166,ECO:0000303\|PubMed:11374898;Dbxref=PMID:11230166,PMID:11374898
Q9BX66	738	793	738	793	Alternative sequence	ID=VSP_050907;Note=In isoform 4 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11230166,ECO:0000303\|PubMed:11374898;Dbxref=PMID:11230166,PMID:11374898
Q9BX66	738	793	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	738	793	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	738	793	793	852	Domain	Note=SH3 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00192
Q9BX66	738	793	793	852	Domain	Note=SH3 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00192
Q9BX66	955	1212	800	1292	Alternative sequence	ID=VSP_050909;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9BX66	955	1212	800	1292	Alternative sequence	ID=VSP_050909;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9BX66	955	1212	955	1212	Alternative sequence	ID=VSP_050911;Note=In isoform 4%2C isoform 5%2C isoform 6%2C isoform 8%2C isoform 9%2C isoform 10 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:1071819
Q9BX66	955	1212	955	1212	Alternative sequence	ID=VSP_050911;Note=In isoform 4%2C isoform 5%2C isoform 6%2C isoform 8%2C isoform 9%2C isoform 10 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:1071819
Q9BX66	955	1212	955	1117	Alternative sequence	ID=VSP_050910;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	955	1212	955	1117	Alternative sequence	ID=VSP_050910;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	955	1212	956	975	Alternative sequence	ID=VSP_050912;Note=In isoform 3. FSSHSKLITPAPSSLPHSRR->LSHHSLRAGPDLTESEKSYV;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	955	1212	956	975	Alternative sequence	ID=VSP_050912;Note=In isoform 3. FSSHSKLITPAPSSLPHSRR->LSHHSLRAGPDLTESEKSYV;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	955	1212	976	1213	Alternative sequence	ID=VSP_050913;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	955	1212	976	1213	Alternative sequence	ID=VSP_050913;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	955	1212	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	955	1212	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	955	1212	1156	1156	Sequence conflict	Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	955	1212	1156	1156	Sequence conflict	Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	955	1212	1156	1156	Sequence conflict	Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	955	1212	1156	1156	Sequence conflict	Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q9BX66	25	57	26	57	Alternative sequence	ID=VSP_050895;Note=In isoform 4%2C isoform 7%2C isoform 8%2C isoform 10 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11230166,ECO:0000303\|PubMed:11371513,ECO:0000303\|PubMed:11374898,ECO:
Q9BX66	25	57	26	57	Alternative sequence	ID=VSP_050895;Note=In isoform 4%2C isoform 7%2C isoform 8%2C isoform 10 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11230166,ECO:0000303\|PubMed:11371513,ECO:0000303\|PubMed:11374898,ECO:
Q9BX66	25	57	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	25	57	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	147	269	147	215	Alternative sequence	ID=VSP_050898;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	147	269	147	215	Alternative sequence	ID=VSP_050898;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	147	269	148	270	Alternative sequence	ID=VSP_050899;Note=In isoform 4%2C isoform 6%2C isoform 8%2C isoform 9 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718198,ECO:0000303\|PubMed:11371513,ECO:0000303\|PubMed:11
Q9BX66	147	269	148	270	Alternative sequence	ID=VSP_050899;Note=In isoform 4%2C isoform 6%2C isoform 8%2C isoform 9 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718198,ECO:0000303\|PubMed:11371513,ECO:0000303\|PubMed:11
Q9BX66	147	269	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	147	269	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	147	269	242	242	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24275569;Dbxref=PMID:24275569
Q9BX66	147	269	242	242	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24275569;Dbxref=PMID:24275569
Q9BX66	147	269	259	259	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24275569;Dbxref=PMID:24275569
Q9BX66	147	269	259	259	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24275569;Dbxref=PMID:24275569
Q9BX66	147	269	175	175	Natural variant	ID=VAR_047653;Note=G->V;Dbxref=dbSNP:rs7081076
Q9BX66	147	269	175	175	Natural variant	ID=VAR_047653;Note=G->V;Dbxref=dbSNP:rs7081076
Q9BX66	147	269	195	195	Natural variant	ID=VAR_035661;Note=In a breast cancer sample%3B somatic mutation. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q9BX66	147	269	195	195	Natural variant	ID=VAR_035661;Note=In a breast cancer sample%3B somatic mutation. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q9BX66	147	269	237	237	Natural variant	ID=VAR_019654;Note=Has a protective role in both obesity and diabetes. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11532984;Dbxref=dbSNP:rs2281939,PMID:11532984
Q9BX66	147	269	237	237	Natural variant	ID=VAR_019654;Note=Has a protective role in both obesity and diabetes. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11532984;Dbxref=dbSNP:rs2281939,PMID:11532984
Q9BX66	147	269	226	228	Sequence conflict	Note=RAS->SAC;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	147	269	226	228	Sequence conflict	Note=RAS->SAC;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	147	269	264	264	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	147	269	264	264	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	318	328	319	328	Alternative sequence	ID=VSP_041193;Note=In isoform 12. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	318	328	319	328	Alternative sequence	ID=VSP_041193;Note=In isoform 12. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	318	328	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	318	328	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	407	432	408	453	Alternative sequence	ID=VSP_050900;Note=In isoform 3%2C isoform 4%2C isoform 7%2C isoform 8%2C isoform 9%2C isoform 10%2C isoform 11 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718
Q9BX66	407	432	408	453	Alternative sequence	ID=VSP_050900;Note=In isoform 3%2C isoform 4%2C isoform 7%2C isoform 8%2C isoform 9%2C isoform 10%2C isoform 11 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718
Q9BX66	407	432	431	451	Alternative sequence	ID=VSP_050901;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11371513,ECO:0000303\|PubMed:11374898,ECO:0000303\|PubMed:11532984;Dbxref=PMID:11371513,PMID:11374898,PMID:11532984
Q9BX66	407	432	431	451	Alternative sequence	ID=VSP_050901;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11371513,ECO:0000303\|PubMed:11374898,ECO:0000303\|PubMed:11532984;Dbxref=PMID:11371513,PMID:11374898,PMID:11532984
Q9BX66	407	432	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	407	432	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	407	432	366	469	Domain	Note=SoHo;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00195
Q9BX66	407	432	366	469	Domain	Note=SoHo;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00195
Q9BX66	432	453	408	453	Alternative sequence	ID=VSP_050900;Note=In isoform 3%2C isoform 4%2C isoform 7%2C isoform 8%2C isoform 9%2C isoform 10%2C isoform 11 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718
Q9BX66	432	453	408	453	Alternative sequence	ID=VSP_050900;Note=In isoform 3%2C isoform 4%2C isoform 7%2C isoform 8%2C isoform 9%2C isoform 10%2C isoform 11 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718
Q9BX66	432	453	431	451	Alternative sequence	ID=VSP_050901;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11371513,ECO:0000303\|PubMed:11374898,ECO:0000303\|PubMed:11532984;Dbxref=PMID:11371513,PMID:11374898,PMID:11532984
Q9BX66	432	453	431	451	Alternative sequence	ID=VSP_050901;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11371513,ECO:0000303\|PubMed:11374898,ECO:0000303\|PubMed:11532984;Dbxref=PMID:11371513,PMID:11374898,PMID:11532984
Q9BX66	432	453	434	453	Alternative sequence	ID=VSP_050902;Note=In isoform 2. DNPYTPTYQFPASTPSPKSE->TKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVAGTA;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	432	453	434	453	Alternative sequence	ID=VSP_050902;Note=In isoform 2. DNPYTPTYQFPASTPSPKSE->TKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVAGTA;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	432	453	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	432	453	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	432	453	366	469	Domain	Note=SoHo;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00195
Q9BX66	432	453	366	469	Domain	Note=SoHo;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00195
Q9BX66	579	600	552	635	Alternative sequence	ID=VSP_050903;Note=In isoform 4%2C isoform 7%2C isoform 9 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718198,ECO:0000303\|PubMed:11230166,ECO:0000303\|PubMed:11374898,ECO:0000303\|PubMed
Q9BX66	579	600	552	635	Alternative sequence	ID=VSP_050903;Note=In isoform 4%2C isoform 7%2C isoform 9 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718198,ECO:0000303\|PubMed:11230166,ECO:0000303\|PubMed:11374898,ECO:0000303\|PubMed
Q9BX66	579	600	580	635	Alternative sequence	ID=VSP_050905;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:12504111;Dbxref=PMID:12504111
Q9BX66	579	600	580	635	Alternative sequence	ID=VSP_050905;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:12504111;Dbxref=PMID:12504111
Q9BX66	579	600	580	601	Alternative sequence	ID=VSP_050904;Note=In isoform 8 and isoform 12. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11371513;Dbxref=PMID:11371513
Q9BX66	579	600	580	601	Alternative sequence	ID=VSP_050904;Note=In isoform 8 and isoform 12. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11371513;Dbxref=PMID:11371513
Q9BX66	579	600	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	579	600	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	601	634	552	635	Alternative sequence	ID=VSP_050903;Note=In isoform 4%2C isoform 7%2C isoform 9 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718198,ECO:0000303\|PubMed:11230166,ECO:0000303\|PubMed:11374898,ECO:0000303\|PubMed
Q9BX66	601	634	552	635	Alternative sequence	ID=VSP_050903;Note=In isoform 4%2C isoform 7%2C isoform 9 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718198,ECO:0000303\|PubMed:11230166,ECO:0000303\|PubMed:11374898,ECO:0000303\|PubMed
Q9BX66	601	634	580	635	Alternative sequence	ID=VSP_050905;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:12504111;Dbxref=PMID:12504111
Q9BX66	601	634	580	635	Alternative sequence	ID=VSP_050905;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:12504111;Dbxref=PMID:12504111
Q9BX66	601	634	580	601	Alternative sequence	ID=VSP_050904;Note=In isoform 8 and isoform 12. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11371513;Dbxref=PMID:11371513
Q9BX66	601	634	580	601	Alternative sequence	ID=VSP_050904;Note=In isoform 8 and isoform 12. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11371513;Dbxref=PMID:11371513
Q9BX66	601	634	602	635	Alternative sequence	ID=VSP_050906;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	601	634	602	635	Alternative sequence	ID=VSP_050906;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	601	634	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	601	634	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	601	634	609	609	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q62417
Q9BX66	601	634	609	609	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q62417
Q9BX66	601	634	607	607	Sequence conflict	Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	601	634	607	607	Sequence conflict	Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	601	634	610	610	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	601	634	610	610	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	738	793	738	793	Alternative sequence	ID=VSP_050907;Note=In isoform 4 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11230166,ECO:0000303\|PubMed:11374898;Dbxref=PMID:11230166,PMID:11374898
Q9BX66	738	793	738	793	Alternative sequence	ID=VSP_050907;Note=In isoform 4 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11230166,ECO:0000303\|PubMed:11374898;Dbxref=PMID:11230166,PMID:11374898
Q9BX66	738	793	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	738	793	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	738	793	793	852	Domain	Note=SH3 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00192
Q9BX66	738	793	793	852	Domain	Note=SH3 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00192
Q9BX66	955	1212	800	1292	Alternative sequence	ID=VSP_050909;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9BX66	955	1212	800	1292	Alternative sequence	ID=VSP_050909;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9BX66	955	1212	955	1212	Alternative sequence	ID=VSP_050911;Note=In isoform 4%2C isoform 5%2C isoform 6%2C isoform 8%2C isoform 9%2C isoform 10 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:1071819
Q9BX66	955	1212	955	1212	Alternative sequence	ID=VSP_050911;Note=In isoform 4%2C isoform 5%2C isoform 6%2C isoform 8%2C isoform 9%2C isoform 10 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:1071819
Q9BX66	955	1212	955	1117	Alternative sequence	ID=VSP_050910;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	955	1212	955	1117	Alternative sequence	ID=VSP_050910;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	955	1212	956	975	Alternative sequence	ID=VSP_050912;Note=In isoform 3. FSSHSKLITPAPSSLPHSRR->LSHHSLRAGPDLTESEKSYV;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	955	1212	956	975	Alternative sequence	ID=VSP_050912;Note=In isoform 3. FSSHSKLITPAPSSLPHSRR->LSHHSLRAGPDLTESEKSYV;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	955	1212	976	1213	Alternative sequence	ID=VSP_050913;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	955	1212	976	1213	Alternative sequence	ID=VSP_050913;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	955	1212	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	955	1212	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	955	1212	1156	1156	Sequence conflict	Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	955	1212	1156	1156	Sequence conflict	Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	955	1212	1156	1156	Sequence conflict	Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	955	1212	1156	1156	Sequence conflict	Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q9BX66	25	57	26	57	Alternative sequence	ID=VSP_050895;Note=In isoform 4%2C isoform 7%2C isoform 8%2C isoform 10 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11230166,ECO:0000303\|PubMed:11371513,ECO:0000303\|PubMed:11374898,ECO:
Q9BX66	25	57	26	57	Alternative sequence	ID=VSP_050895;Note=In isoform 4%2C isoform 7%2C isoform 8%2C isoform 10 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11230166,ECO:0000303\|PubMed:11371513,ECO:0000303\|PubMed:11374898,ECO:
Q9BX66	25	57	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	25	57	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	147	269	147	215	Alternative sequence	ID=VSP_050898;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	147	269	147	215	Alternative sequence	ID=VSP_050898;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	147	269	148	270	Alternative sequence	ID=VSP_050899;Note=In isoform 4%2C isoform 6%2C isoform 8%2C isoform 9 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718198,ECO:0000303\|PubMed:11371513,ECO:0000303\|PubMed:11
Q9BX66	147	269	148	270	Alternative sequence	ID=VSP_050899;Note=In isoform 4%2C isoform 6%2C isoform 8%2C isoform 9 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718198,ECO:0000303\|PubMed:11371513,ECO:0000303\|PubMed:11
Q9BX66	147	269	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	147	269	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	147	269	242	242	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24275569;Dbxref=PMID:24275569
Q9BX66	147	269	242	242	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24275569;Dbxref=PMID:24275569
Q9BX66	147	269	259	259	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24275569;Dbxref=PMID:24275569
Q9BX66	147	269	259	259	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24275569;Dbxref=PMID:24275569
Q9BX66	147	269	175	175	Natural variant	ID=VAR_047653;Note=G->V;Dbxref=dbSNP:rs7081076
Q9BX66	147	269	175	175	Natural variant	ID=VAR_047653;Note=G->V;Dbxref=dbSNP:rs7081076
Q9BX66	147	269	195	195	Natural variant	ID=VAR_035661;Note=In a breast cancer sample%3B somatic mutation. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q9BX66	147	269	195	195	Natural variant	ID=VAR_035661;Note=In a breast cancer sample%3B somatic mutation. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974
Q9BX66	147	269	237	237	Natural variant	ID=VAR_019654;Note=Has a protective role in both obesity and diabetes. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11532984;Dbxref=dbSNP:rs2281939,PMID:11532984
Q9BX66	147	269	237	237	Natural variant	ID=VAR_019654;Note=Has a protective role in both obesity and diabetes. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11532984;Dbxref=dbSNP:rs2281939,PMID:11532984
Q9BX66	147	269	226	228	Sequence conflict	Note=RAS->SAC;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	147	269	226	228	Sequence conflict	Note=RAS->SAC;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	147	269	264	264	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	147	269	264	264	Sequence conflict	Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	318	328	319	328	Alternative sequence	ID=VSP_041193;Note=In isoform 12. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	318	328	319	328	Alternative sequence	ID=VSP_041193;Note=In isoform 12. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	318	328	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	318	328	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	432	453	408	453	Alternative sequence	ID=VSP_050900;Note=In isoform 3%2C isoform 4%2C isoform 7%2C isoform 8%2C isoform 9%2C isoform 10%2C isoform 11 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718
Q9BX66	432	453	408	453	Alternative sequence	ID=VSP_050900;Note=In isoform 3%2C isoform 4%2C isoform 7%2C isoform 8%2C isoform 9%2C isoform 10%2C isoform 11 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718
Q9BX66	432	453	431	451	Alternative sequence	ID=VSP_050901;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11371513,ECO:0000303\|PubMed:11374898,ECO:0000303\|PubMed:11532984;Dbxref=PMID:11371513,PMID:11374898,PMID:11532984
Q9BX66	432	453	431	451	Alternative sequence	ID=VSP_050901;Note=In isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11371513,ECO:0000303\|PubMed:11374898,ECO:0000303\|PubMed:11532984;Dbxref=PMID:11371513,PMID:11374898,PMID:11532984
Q9BX66	432	453	434	453	Alternative sequence	ID=VSP_050902;Note=In isoform 2. DNPYTPTYQFPASTPSPKSE->TKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVAGTA;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	432	453	434	453	Alternative sequence	ID=VSP_050902;Note=In isoform 2. DNPYTPTYQFPASTPSPKSE->TKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVAGTA;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	432	453	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	432	453	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	432	453	366	469	Domain	Note=SoHo;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00195
Q9BX66	432	453	366	469	Domain	Note=SoHo;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00195
Q9BX66	551	578	552	635	Alternative sequence	ID=VSP_050903;Note=In isoform 4%2C isoform 7%2C isoform 9 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718198,ECO:0000303\|PubMed:11230166,ECO:0000303\|PubMed:11374898,ECO:0000303\|PubMed
Q9BX66	551	578	552	635	Alternative sequence	ID=VSP_050903;Note=In isoform 4%2C isoform 7%2C isoform 9 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718198,ECO:0000303\|PubMed:11230166,ECO:0000303\|PubMed:11374898,ECO:0000303\|PubMed
Q9BX66	551	578	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	551	578	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	551	578	556	556	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24275569;Dbxref=PMID:24275569
Q9BX66	551	578	556	556	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24275569;Dbxref=PMID:24275569
Q9BX66	579	600	552	635	Alternative sequence	ID=VSP_050903;Note=In isoform 4%2C isoform 7%2C isoform 9 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718198,ECO:0000303\|PubMed:11230166,ECO:0000303\|PubMed:11374898,ECO:0000303\|PubMed
Q9BX66	579	600	552	635	Alternative sequence	ID=VSP_050903;Note=In isoform 4%2C isoform 7%2C isoform 9 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718198,ECO:0000303\|PubMed:11230166,ECO:0000303\|PubMed:11374898,ECO:0000303\|PubMed
Q9BX66	579	600	580	635	Alternative sequence	ID=VSP_050905;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:12504111;Dbxref=PMID:12504111
Q9BX66	579	600	580	635	Alternative sequence	ID=VSP_050905;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:12504111;Dbxref=PMID:12504111
Q9BX66	579	600	580	601	Alternative sequence	ID=VSP_050904;Note=In isoform 8 and isoform 12. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11371513;Dbxref=PMID:11371513
Q9BX66	579	600	580	601	Alternative sequence	ID=VSP_050904;Note=In isoform 8 and isoform 12. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11371513;Dbxref=PMID:11371513
Q9BX66	579	600	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	579	600	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	601	634	552	635	Alternative sequence	ID=VSP_050903;Note=In isoform 4%2C isoform 7%2C isoform 9 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718198,ECO:0000303\|PubMed:11230166,ECO:0000303\|PubMed:11374898,ECO:0000303\|PubMed
Q9BX66	601	634	552	635	Alternative sequence	ID=VSP_050903;Note=In isoform 4%2C isoform 7%2C isoform 9 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10718198,ECO:0000303\|PubMed:11230166,ECO:0000303\|PubMed:11374898,ECO:0000303\|PubMed
Q9BX66	601	634	580	635	Alternative sequence	ID=VSP_050905;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:12504111;Dbxref=PMID:12504111
Q9BX66	601	634	580	635	Alternative sequence	ID=VSP_050905;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:12504111;Dbxref=PMID:12504111
Q9BX66	601	634	580	601	Alternative sequence	ID=VSP_050904;Note=In isoform 8 and isoform 12. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11371513;Dbxref=PMID:11371513
Q9BX66	601	634	580	601	Alternative sequence	ID=VSP_050904;Note=In isoform 8 and isoform 12. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11371513;Dbxref=PMID:11371513
Q9BX66	601	634	602	635	Alternative sequence	ID=VSP_050906;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	601	634	602	635	Alternative sequence	ID=VSP_050906;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	601	634	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	601	634	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	601	634	609	609	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q62417
Q9BX66	601	634	609	609	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q62417
Q9BX66	601	634	607	607	Sequence conflict	Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	601	634	607	607	Sequence conflict	Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	601	634	610	610	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	601	634	610	610	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	738	793	738	793	Alternative sequence	ID=VSP_050907;Note=In isoform 4 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11230166,ECO:0000303\|PubMed:11374898;Dbxref=PMID:11230166,PMID:11374898
Q9BX66	738	793	738	793	Alternative sequence	ID=VSP_050907;Note=In isoform 4 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11230166,ECO:0000303\|PubMed:11374898;Dbxref=PMID:11230166,PMID:11374898
Q9BX66	738	793	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	738	793	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	738	793	793	852	Domain	Note=SH3 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00192
Q9BX66	738	793	793	852	Domain	Note=SH3 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00192
Q9BX66	955	1212	800	1292	Alternative sequence	ID=VSP_050909;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9BX66	955	1212	800	1292	Alternative sequence	ID=VSP_050909;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9BX66	955	1212	955	1212	Alternative sequence	ID=VSP_050911;Note=In isoform 4%2C isoform 5%2C isoform 6%2C isoform 8%2C isoform 9%2C isoform 10 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:1071819
Q9BX66	955	1212	955	1212	Alternative sequence	ID=VSP_050911;Note=In isoform 4%2C isoform 5%2C isoform 6%2C isoform 8%2C isoform 9%2C isoform 10 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:1071819
Q9BX66	955	1212	955	1117	Alternative sequence	ID=VSP_050910;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	955	1212	955	1117	Alternative sequence	ID=VSP_050910;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	955	1212	956	975	Alternative sequence	ID=VSP_050912;Note=In isoform 3. FSSHSKLITPAPSSLPHSRR->LSHHSLRAGPDLTESEKSYV;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	955	1212	956	975	Alternative sequence	ID=VSP_050912;Note=In isoform 3. FSSHSKLITPAPSSLPHSRR->LSHHSLRAGPDLTESEKSYV;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	955	1212	976	1213	Alternative sequence	ID=VSP_050913;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	955	1212	976	1213	Alternative sequence	ID=VSP_050913;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:11374898;Dbxref=PMID:11374898
Q9BX66	955	1212	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	955	1212	1	1292	Chain	ID=PRO_0000072185;Note=Sorbin and SH3 domain-containing protein 1
Q9BX66	955	1212	1156	1156	Sequence conflict	Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	955	1212	1156	1156	Sequence conflict	Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	955	1212	1156	1156	Sequence conflict	Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BX66	955	1212	1156	1156	Sequence conflict	Note=V->G;Ontology_term=ECO:0000305;evidence=ECO:0000305

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3'-UTR located exon skipping events that lost miRNA binding sites in SORBS1

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type	ENST	Exon skip start	Exon skip end	microRNA	Binding site by TargetScan	Binding type by TargetScan	Bdinding site by miRanda	Score of miRanda	Energy by miRanda
Mayo	ENST00000371247	95491035	95491120	hsa-miR-6077	chr10:95491099-95491106	8mer-1a	chr10:95491084-95491106	149.00	-15.89
Mayo	ENST00000371247	95491035	95491120	hsa-miR-6738-3p	chr10:95491080-95491087	8mer-1a	chr10:95491069-95491090	160.00	-24.45
Mayo	ENST00000371247	95491035	95491120	hsa-miR-4642	chr10:95491110-95491117	8mer-1a	chr10:95491102-95491120	152.00	-17.52
Mayo	ENST00000371247	95491035	95491120	hsa-miR-3690	chr10:95491066-95491073	8mer-1a	chr10:95491050-95491073	154.00	-21.52
MSBB	ENST00000371247	95491035	95491120	hsa-miR-6077	chr10:95491099-95491106	8mer-1a	chr10:95491084-95491106	149.00	-15.89
MSBB	ENST00000371247	95491035	95491120	hsa-miR-6738-3p	chr10:95491080-95491087	8mer-1a	chr10:95491069-95491090	160.00	-24.45
MSBB	ENST00000371247	95491035	95491120	hsa-miR-4642	chr10:95491110-95491117	8mer-1a	chr10:95491102-95491120	152.00	-17.52
MSBB	ENST00000371247	95491035	95491120	hsa-miR-3690	chr10:95491066-95491073	8mer-1a	chr10:95491050-95491073	154.00	-21.52
ROSMAP	ENST00000371247	95491035	95491120	hsa-miR-6077	chr10:95491099-95491106	8mer-1a	chr10:95491084-95491106	149.00	-15.89
ROSMAP	ENST00000371247	95491035	95491120	hsa-miR-6738-3p	chr10:95491080-95491087	8mer-1a	chr10:95491069-95491090	160.00	-24.45
ROSMAP	ENST00000371247	95491035	95491120	hsa-miR-4642	chr10:95491110-95491117	8mer-1a	chr10:95491102-95491120	152.00	-17.52
ROSMAP	ENST00000371247	95491035	95491120	hsa-miR-3690	chr10:95491066-95491073	8mer-1a	chr10:95491050-95491073	154.00	-21.52

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SNVs in the skipped exons for SORBS1

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for SORBS1

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info	Cohort	Tissue	SE id	Coefficient	P-value	Chromosome	Strand	E1 start	E1 end	Skipped start	Skipped end	E2 start	E2 end
ADstage	MSBB	IFG	exon_skip_215667	-4.114576e-01	2.960356e-02	chr10	-	95399017	95399189	95406118	95406147	95410633	95410777
ADstage	MSBB	PG	exon_skip_102016	-4.571908e-01	3.430000e-12	chr10	-	95367650	95367699	95371326	95371427	95375973	95376056
ADstage	MSBB	PG	exon_skip_264227	-3.652611e-01	5.390000e-08	chr10	-	95354882	95354967	95355627	95357105	95357631	95357803
ADstage	ROSMAP	PCC	exon_skip_102016	-3.503851e-01	1.320000e-07	chr10	-	95367650	95367699	95371326	95371427	95375973	95376056
ADstage	ROSMAP	PCC	exon_skip_59261	-3.246518e-01	1.140000e-06	chr10	-	95367650	95367699	95371326	95372049	95375973	95376056
CDR	MSBB	IFG	exon_skip_215667	-4.435476e-01	1.806998e-02	chr10	-	95399017	95399189	95406118	95406147	95410633	95410777
CDR	MSBB	IFG	exon_skip_3191	3.795731e-01	4.634831e-02	chr10	-	95410633	95410777	95414830	95414862	95421961	95422073
CDR	MSBB	IFG	exon_skip_102016	-3.752076e-01	4.913174e-02	chr10	-	95367650	95367699	95371326	95371427	95375973	95376056
CDR	MSBB	PG	exon_skip_102016	-4.785645e-01	2.320000e-13	chr10	-	95367650	95367699	95371326	95371427	95375973	95376056
CDR	MSBB	PG	exon_skip_264227	-3.659109e-01	5.080000e-08	chr10	-	95354882	95354967	95355627	95357105	95357631	95357803

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SORBS1

sQTL information located at the skipped exons.

Tissue type	Exon skip ID	SNP id	Location	P-value	FDR
CB	exon_skip_274204	rs10882583	chr10:95349262	3.557332e-09	2.558621e-06
CB	exon_skip_274204	rs1410601	chr10:95310904	7.539222e-08	3.744937e-05
CB	exon_skip_274204	rs7084752	chr10:95310358	6.401923e-06	1.783525e-03
CB	exon_skip_274204	rs1410600	chr10:95310937	1.429622e-05	3.527387e-03
CB	exon_skip_274204	rs3193970	chr10:95312251	1.557856e-05	3.796775e-03
CB	exon_skip_274204	rs7076888	chr10:95356462	1.601786e-05	3.873216e-03
CB	exon_skip_274204	rs17534496	chr10:95422746	6.740274e-05	1.255990e-02
CB	exon_skip_274204	rs11188311	chr10:95394941	8.530640e-05	1.527436e-02
CB	exon_skip_274204	rs1410059	chr10:95412838	3.830795e-04	4.898481e-02
TC	exon_skip_274204	rs10882583	chr10:95349262	1.501781e-05	3.460504e-03
TC	exon_skip_274204	rs1410601	chr10:95310904	9.280826e-05	1.543895e-02
TC	exon_skip_274204	rs7076888	chr10:95356462	9.787679e-05	1.607064e-02
TC	exon_skip_274204	rs3814147	chr10:95311577	3.305499e-04	4.221685e-02
TC	exon_skip_274204	rs11188311	chr10:95394941	3.544654e-04	4.458621e-02
HCC	exon_skip_165877	rs10882583	chr10:95349262	1.547690e-04	1.317640e-02
HCC	exon_skip_230424	rs1410060	chr10:95412855	2.109759e-04	1.693267e-02
HCC	exon_skip_59154	rs11188325	chr10:95457319	2.499455e-04	1.948417e-02
HCC	exon_skip_59154	rs11188326	chr10:95458809	2.499455e-04	1.948417e-02
HCC	exon_skip_158407	rs7089306	chr10:95480024	4.892188e-04	3.334750e-02
HCC	exon_skip_165877	rs2025851	chr10:95380197	7.014994e-04	4.428228e-02
HCC	exon_skip_230424	rs7096788	chr10:95353497	7.949530e-04	4.886668e-02
HCC	exon_skip_230424	rs10882584	chr10:95362673	7.949530e-04	4.886668e-02
PCC	exon_skip_164577	rs11188325	chr10:95457319	4.809469e-05	9.665363e-03
PCC	exon_skip_164577	rs11188326	chr10:95458809	4.809469e-05	9.665363e-03
DLPFC	exon_skip_102016	rs11188258	chr10:95284203	3.877486e-04	2.638317e-02
DLPFC	exon_skip_293592	rs11595114	chr10:95471763	4.489719e-04	2.959654e-02

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Correlation with RNA binding proteins (RBPs) for SORBS1

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	ELAVL1	exon_skip_264227	4.772457e-01	2.014379e-10
CB	MATR3	exon_skip_264227	4.624496e-01	8.423055e-10
CB	FXR2	exon_skip_264227	5.289902e-01	7.615561e-13
CB	PCBP1	exon_skip_264227	4.955126e-01	3.126010e-11
CB	HNRNPK	exon_skip_264227	4.430853e-01	4.955598e-09
CB	PCBP2	exon_skip_264227	4.699512e-01	4.113036e-10
CB	SF1	exon_skip_264227	4.035546e-01	1.330853e-07
CB	PUM1	exon_skip_264227	4.341368e-01	1.083475e-08
CB	HNRNPA2B1	exon_skip_264227	4.241073e-01	2.535494e-08
CB	RALYL	exon_skip_264227	5.195832e-01	2.253955e-12
CB	EIF4G2	exon_skip_264227	4.040683e-01	1.278542e-07
CB	HNRNPL	exon_skip_264227	4.521994e-01	2.181951e-09
CB	CELF1	exon_skip_264227	4.078833e-01	9.472473e-08
CB	RBM23	exon_skip_264227	4.277217e-01	1.872313e-08
CB	SRSF4	exon_skip_264227	4.620356e-01	8.758482e-10
CB	HNRNPH2	exon_skip_264227	4.573027e-01	1.363776e-09
CB	EIF4B	exon_skip_264227	4.112156e-01	7.266944e-08
CB	HNRNPF	exon_skip_264227	4.108893e-01	7.458973e-08
CB	HNRNPA0	exon_skip_101915	4.577799e-01	1.295419e-08
CB	NUP42	exon_skip_101915	4.955231e-01	4.829046e-10
CB	SRSF9	exon_skip_101915	4.011292e-01	9.036513e-07
CB	SF1	exon_skip_102016	4.639192e-01	8.298977e-10
CB	HNRNPA0	exon_skip_102016	6.162115e-01	6.801472e-18
CB	HNRNPDL	exon_skip_102016	4.653380e-01	7.257904e-10
CB	HNRNPD	exon_skip_102016	4.543058e-01	2.025489e-09
CB	NUP42	exon_skip_102016	4.993246e-01	2.418965e-11
CB	PTBP3	exon_skip_102016	4.792175e-01	1.892619e-10
CB	PABPC1	exon_skip_102016	4.678703e-01	5.704872e-10
CB	SRSF9	exon_skip_102016	4.944856e-01	4.017749e-11
CB	SART3	exon_skip_102016	5.161404e-01	3.894327e-12
CB	CNOT4	exon_skip_190729	4.731102e-01	1.497537e-08
CB	TRA2A	exon_skip_190729	4.415619e-01	1.622089e-07
CB	UNK	exon_skip_59261	4.563930e-01	1.672692e-09
CB	PCBP2	exon_skip_59261	4.048764e-01	1.316568e-07
CB	G3BP2	exon_skip_59261	4.335788e-01	1.265361e-08
CB	HNRNPA0	exon_skip_59261	4.755458e-01	2.716697e-10
CB	HNRNPDL	exon_skip_59261	4.067656e-01	1.135991e-07
CB	NUP42	exon_skip_59261	6.105849e-01	1.626853e-17
CB	PABPC1	exon_skip_59261	4.319396e-01	1.455113e-08
CB	PABPN1	exon_skip_294830	-4.083423e-01	6.634077e-07
CB	PABPN1	exon_skip_36854	-4.370888e-01	6.692413e-07
CB	CNOT4	exon_skip_253982	-5.107339e-01	1.331564e-10
CB	PCBP4	exon_skip_253982	5.180709e-01	6.502913e-11
CB	TRA2A	exon_skip_253982	-5.186316e-01	6.152020e-11
CB	PTBP1	exon_skip_253982	-4.234996e-01	2.053032e-07
CB	ELAVL1	exon_skip_50600	-4.661186e-01	1.623834e-09
CB	RALYL	exon_skip_50600	-4.126416e-01	1.401752e-07
CB	TIA1	exon_skip_293592	-4.388380e-01	8.976634e-09
CB	NUP42	exon_skip_293592	-4.207108e-01	4.108105e-08
CB	RALYL	exon_skip_293592	-5.335113e-01	6.282892e-13
CB	PABPC1	exon_skip_293592	-4.176337e-01	5.271796e-08
CB	SART3	exon_skip_293592	-4.265735e-01	2.536536e-08
DLPFC	KHDRBS2	exon_skip_102016	7.217186e-01	6.626568e-53
FL	HNRNPH2	exon_skip_209242	4.191916e-01	7.913050e-10
FL	KHDRBS2	exon_skip_102016	4.442232e-01	6.199442e-11
FL	KHDRBS3	exon_skip_102016	6.998769e-01	2.579143e-30
FL	ENOX1	exon_skip_102016	4.138303e-01	1.497863e-09
FL	HNRNPA0	exon_skip_102016	5.753001e-01	9.398366e-19
FL	HNRNPDL	exon_skip_102016	4.021976e-01	4.671253e-09
FL	NUP42	exon_skip_102016	4.318834e-01	2.346994e-10
FL	SRSF9	exon_skip_102016	5.568839e-01	1.933163e-17
FL	ZCRB1	exon_skip_102016	4.212854e-01	7.060220e-10
FL	SART3	exon_skip_102016	4.163493e-01	1.164100e-09
FL	ELAVL4	exon_skip_50600	-5.524213e-01	8.185491e-17
FL	TIA1	exon_skip_50600	-6.089752e-01	5.668797e-21
FL	PCBP2	exon_skip_50600	-4.271863e-01	5.805792e-10
FL	FUBP1	exon_skip_50600	-5.787186e-01	1.198906e-18
FL	RBM45	exon_skip_50600	-6.146184e-01	1.958299e-21
FL	NUP42	exon_skip_50600	-4.387750e-01	1.739964e-10
FL	RALYL	exon_skip_50600	-6.279294e-01	1.463753e-22
FL	SRSF9	exon_skip_50600	-6.216898e-01	5.014064e-22
FL	SART3	exon_skip_50600	-4.864661e-01	7.361698e-13
FL	RBM4	exon_skip_50600	-4.734723e-01	3.552009e-12
FL	ELAVL4	exon_skip_293592	-6.733548e-01	2.227289e-27
FL	TIA1	exon_skip_293592	-5.409594e-01	2.281114e-16
FL	RBM3	exon_skip_293592	-4.011876e-01	5.145569e-09
FL	FUBP1	exon_skip_293592	-5.653954e-01	4.891953e-18
FL	RBM45	exon_skip_293592	-5.687372e-01	2.821311e-18
FL	NUP42	exon_skip_293592	-4.794042e-01	1.025287e-12
FL	RALYL	exon_skip_293592	-6.802715e-01	4.091113e-28
FL	SART3	exon_skip_293592	-4.937045e-01	1.684654e-13
FL	MSI1	exon_skip_59154	5.365526e-01	3.715933e-16
FL	SRSF11	exon_skip_59154	-4.551611e-01	1.616694e-11
FL	HNRNPK	exon_skip_59154	-4.953480e-01	1.179789e-13
FL	PCBP2	exon_skip_59154	-4.242802e-01	4.690036e-10
FL	RBM45	exon_skip_59154	-5.582489e-01	1.286867e-17
FL	RALYL	exon_skip_59154	-5.756425e-01	7.233707e-19
FL	EIF4G2	exon_skip_59154	-5.376972e-01	3.130555e-16
FL	HNRNPL	exon_skip_59154	-4.241204e-01	4.768327e-10
FL	SRSF1	exon_skip_59154	-5.337140e-01	5.668795e-16
FL	SRSF9	exon_skip_59154	-5.871069e-01	9.861855e-20
FL	NOVA1	exon_skip_59154	-4.622249e-01	7.127397e-12
FL	RBM4	exon_skip_59154	-4.425455e-01	6.666987e-11
FL	MBNL1	exon_skip_158407	-5.150457e-01	8.278231e-15
FL	TRNAU1AP	exon_skip_158407	-4.328097e-01	1.913410e-10
FL	HNRNPK	exon_skip_158407	-5.344328e-01	5.095741e-16
FL	PCBP2	exon_skip_158407	-4.010027e-01	4.786150e-09
FL	FUBP1	exon_skip_158407	-5.858439e-01	1.233041e-19
FL	ENOX1	exon_skip_158407	-5.141004e-01	9.441050e-15
FL	NUP42	exon_skip_158407	-4.689334e-01	3.217290e-12
FL	RALYL	exon_skip_158407	-6.522651e-01	2.249406e-25
FL	SRSF1	exon_skip_158407	-5.340788e-01	5.370443e-16
HCC	MSI1	exon_skip_195627	-4.995975e-01	1.213779e-18
HCC	SFPQ	exon_skip_195627	-4.140448e-01	9.863155e-13
HCC	RBM6	exon_skip_195627	-4.546728e-01	2.472843e-15
HCC	SRSF11	exon_skip_195627	-4.055514e-01	3.125998e-12
HCC	RBM5	exon_skip_195627	-4.125086e-01	1.218093e-12
HCC	PCBP4	exon_skip_195627	-5.214955e-01	1.931409e-20
HCC	UNK	exon_skip_195627	-5.047350e-01	4.718347e-19
HCC	PCBP2	exon_skip_195627	-4.739201e-01	1.083297e-16
HCC	HNRNPAB	exon_skip_195627	-4.028255e-01	4.495655e-12
HCC	PTBP1	exon_skip_195627	-5.407184e-01	3.949380e-22
HCC	SRSF5	exon_skip_195627	-4.801091e-01	3.797161e-17
HCC	HNRNPF	exon_skip_195627	-5.516039e-01	3.898068e-23
HCC	FUS	exon_skip_139426	-4.205164e-01	3.213620e-12
HCC	TARDBP	exon_skip_264227	-4.124516e-01	1.227650e-12
HCC	PABPN1	exon_skip_264227	-5.252630e-01	9.187529e-21
HCC	RBM25	exon_skip_264227	-4.589598e-01	1.253095e-15
HCC	ZNF326	exon_skip_264227	-6.464872e-01	1.058916e-33
HCC	SFPQ	exon_skip_264227	-6.078954e-01	5.655212e-29
HCC	ZNF638	exon_skip_264227	-5.080168e-01	2.558702e-19
HCC	RBM6	exon_skip_264227	-6.460293e-01	1.216120e-33
HCC	SRSF11	exon_skip_264227	-5.279023e-01	5.429376e-21
HCC	CNOT4	exon_skip_264227	-4.191523e-01	4.851570e-13
HCC	RBM5	exon_skip_264227	-5.982103e-01	6.912367e-28
HCC	IGF2BP2	exon_skip_264227	-4.262494e-01	1.774068e-13
HCC	TRNAU1AP	exon_skip_264227	-5.735345e-01	2.813941e-25
HCC	RBM47	exon_skip_264227	-4.824041e-01	2.560251e-17
HCC	PCBP1	exon_skip_264227	-4.886827e-01	8.577167e-18
HCC	PCBP4	exon_skip_264227	-5.096774e-01	1.872573e-19
HCC	UNK	exon_skip_264227	-5.805796e-01	5.330295e-26
HCC	TRA2A	exon_skip_264227	-4.327634e-01	6.899980e-14
HCC	PCBP2	exon_skip_264227	-4.700836e-01	2.052967e-16
HCC	SF1	exon_skip_264227	-5.118698e-01	1.236835e-19
HCC	KHDRBS3	exon_skip_264227	-5.302148e-01	3.411445e-21
HCC	FUBP1	exon_skip_264227	-4.798558e-01	3.965309e-17
HCC	HNRNPA2B1	exon_skip_264227	-5.395632e-01	5.024809e-22
HCC	RBM45	exon_skip_264227	-5.687963e-01	8.425086e-25
HCC	EIF4G2	exon_skip_264227	-5.715013e-01	4.514666e-25
HCC	PTBP1	exon_skip_264227	-7.344379e-01	1.578574e-47
HCC	SRSF1	exon_skip_264227	-4.588191e-01	1.281543e-15
HCC	SRSF4	exon_skip_264227	-5.275720e-01	5.800309e-21
HCC	SRSF5	exon_skip_264227	-4.457441e-01	9.883518e-15
HCC	HNRNPF	exon_skip_264227	-7.217312e-01	3.337898e-45
HCC	ZC3H10	exon_skip_264227	-5.728418e-01	3.306882e-25
HCC	RBM4B	exon_skip_264227	-6.025592e-01	2.270058e-28
HCC	DAZAP1	exon_skip_101915	-4.736354e-01	6.066835e-16
HCC	SF1	exon_skip_101915	-4.199293e-01	1.572156e-12
HCC	KHDRBS3	exon_skip_101915	-4.304744e-01	3.739757e-13
HCC	DAZAP1	exon_skip_102016	-5.833964e-01	2.709767e-26
HCC	CNOT4	exon_skip_102016	-4.500298e-01	5.108416e-15
HCC	TRA2A	exon_skip_102016	-4.613401e-01	8.556057e-16
HCC	KHDRBS2	exon_skip_102016	4.108553e-01	1.526896e-12
HCC	SF1	exon_skip_102016	-5.362329e-01	1.000963e-21
HCC	KHDRBS3	exon_skip_102016	-5.121692e-01	1.168446e-19
HCC	ENOX1	exon_skip_102016	-4.150647e-01	8.568456e-13
HCC	PABPC5	exon_skip_102016	-4.099337e-01	1.730901e-12
HCC	PABPC1	exon_skip_102016	-5.243664e-01	1.097375e-20
HCC	DAZAP1	exon_skip_190729	-4.305443e-01	1.447975e-13
HCC	TRA2A	exon_skip_190729	-4.293522e-01	1.717238e-13
HCC	SF1	exon_skip_190729	-4.641943e-01	8.826499e-16
HCC	KHDRBS3	exon_skip_190729	-4.027715e-01	6.497735e-12
HCC	PABPC1	exon_skip_190729	-4.803680e-01	6.183493e-17
HCC	DAZAP1	exon_skip_59261	-5.914321e-01	3.791671e-27
HCC	RBMS2	exon_skip_59261	-6.622593e-01	7.757951e-36
HCC	RBMS3	exon_skip_59261	-5.014919e-01	8.582805e-19
HCC	MSI1	exon_skip_59261	-7.280333e-01	2.436082e-46
HCC	PABPN1	exon_skip_59261	-5.613798e-01	4.527174e-24
HCC	RBM6	exon_skip_59261	-6.342194e-01	3.985130e-32
HCC	CNOT4	exon_skip_59261	-4.102233e-01	1.664085e-12
HCC	IGF2BP2	exon_skip_59261	-4.566570e-01	1.807481e-15
HCC	PCBP4	exon_skip_59261	-5.042540e-01	5.158283e-19
HCC	UNK	exon_skip_59261	-5.777723e-01	1.039354e-25
HCC	PCBP2	exon_skip_59261	-5.088087e-01	2.205257e-19
HCC	SF1	exon_skip_59261	-4.908208e-01	5.879979e-18
HCC	KHDRBS3	exon_skip_59261	-5.164279e-01	5.171609e-20
HCC	HNRNPAB	exon_skip_59261	-5.263572e-01	7.391490e-21
HCC	PABPC5	exon_skip_59261	-4.087667e-01	2.027700e-12
HCC	PABPC1	exon_skip_59261	-4.817744e-01	2.853484e-17
HCC	PABPC4	exon_skip_59261	-4.835602e-01	2.096824e-17
HCC	SART3	exon_skip_59261	-4.004618e-01	6.144262e-12
HCC	DAZAP1	exon_skip_243691	-4.635536e-01	7.649631e-16
HCC	RBMS2	exon_skip_243691	-5.568095e-01	1.817770e-23
HCC	RBMS3	exon_skip_243691	-4.870918e-01	1.492123e-17
HCC	MSI1	exon_skip_243691	-6.516833e-01	3.777191e-34
HCC	PABPN1	exon_skip_243691	-4.319265e-01	9.622109e-14
HCC	RBM6	exon_skip_243691	-5.453769e-01	2.116001e-22
HCC	IGF2BP2	exon_skip_243691	-4.279436e-01	1.708274e-13
HCC	TRNAU1AP	exon_skip_243691	-4.563041e-01	2.422724e-15
HCC	RBM47	exon_skip_243691	-4.713978e-01	2.129980e-16
HCC	PCBP1	exon_skip_243691	-4.417106e-01	2.274227e-14
HCC	UNK	exon_skip_243691	-4.809679e-01	4.279416e-17
HCC	PCBP2	exon_skip_243691	-4.134786e-01	1.290737e-12
HCC	SF1	exon_skip_243691	-4.334075e-01	7.757730e-14
HCC	KHDRBS3	exon_skip_243691	-4.479162e-01	8.891139e-15
HCC	HNRNPAB	exon_skip_243691	-4.891901e-01	1.034894e-17
HCC	PABPC1	exon_skip_243691	-4.710292e-01	2.263540e-16
HCC	PABPC4	exon_skip_243691	-4.491056e-01	7.410281e-15
HCC	RBM4B	exon_skip_243691	-5.352136e-01	1.735857e-21
HCC	RBM6	exon_skip_238760	-5.305234e-01	3.205415e-21
HCC	PCBP4	exon_skip_50600	4.620168e-01	7.672254e-16
HCC	PCBP2	exon_skip_50600	4.019635e-01	5.039590e-12
HCC	RBM6	exon_skip_293592	6.117101e-01	2.060232e-29
HCC	CNOT4	exon_skip_293592	4.472182e-01	7.884543e-15
HCC	TIA1	exon_skip_293592	4.946008e-01	2.996875e-18
HCC	TRA2A	exon_skip_293592	4.211908e-01	3.642809e-13
HCC	FUBP1	exon_skip_293592	4.833148e-01	2.187719e-17
HCC	RBM45	exon_skip_293592	5.585516e-01	8.501755e-24
HCC	PABPC1	exon_skip_293592	4.480770e-01	6.908551e-15
HCC	RBM4	exon_skip_293592	5.239238e-01	1.197730e-20
HCC	RBM6	exon_skip_230424	4.082780e-01	2.433990e-11
HCC	RBM6	exon_skip_32799	4.026801e-01	5.489756e-12
HCC	TIA1	exon_skip_32799	4.288533e-01	1.499370e-13
HCC	RBM3	exon_skip_32799	5.214558e-01	2.683202e-20
HCC	RBM45	exon_skip_32799	4.354355e-01	5.766583e-14
HCC	PABPC1	exon_skip_32799	4.091824e-01	2.310383e-12
HCC	TRNAU1AP	exon_skip_158407	4.293342e-01	1.137232e-13
HCC	RBM47	exon_skip_158407	4.364460e-01	4.009316e-14
IFG	RBM24	exon_skip_195627	4.684105e-01	1.193705e-02
IFG	MATR3	exon_skip_264227	4.213308e-01	2.555278e-02
IFG	FXR2	exon_skip_264227	6.376305e-01	2.624801e-04
IFG	PCBP4	exon_skip_264227	-4.083574e-01	3.097758e-02
IFG	KHDRBS3	exon_skip_264227	5.531786e-01	2.263814e-03
IFG	RBM24	exon_skip_264227	4.682645e-01	1.196718e-02
IFG	PUM1	exon_skip_264227	4.435929e-01	1.805679e-02
IFG	RALYL	exon_skip_264227	5.619723e-01	1.857073e-03
IFG	PTBP3	exon_skip_264227	5.215103e-01	4.426822e-03
IFG	CELF1	exon_skip_264227	4.091818e-01	3.060727e-02
IFG	KHDRBS3	exon_skip_101915	5.112240e-01	1.067526e-02
IFG	NUP42	exon_skip_101915	4.183930e-01	4.188050e-02
IFG	ZCRB1	exon_skip_101915	4.079332e-01	4.783669e-02
IFG	DAZAP1	exon_skip_102016	-6.350188e-01	2.832407e-04
IFG	PABPN1L	exon_skip_102016	-4.784705e-01	1.000724e-02
IFG	CNOT4	exon_skip_102016	-4.336030e-01	2.115853e-02
IFG	TRA2A	exon_skip_102016	-5.504113e-01	2.406733e-03
IFG	SF1	exon_skip_102016	-4.819181e-01	9.409204e-03
IFG	KHDRBS3	exon_skip_102016	4.052057e-01	3.242671e-02
IFG	PABPC5	exon_skip_102016	-4.163695e-01	2.752789e-02
IFG	PABPC1	exon_skip_102016	-5.002057e-01	6.714679e-03
IFG	KHDRBS3	exon_skip_190729	5.897417e-01	3.868455e-03
IFG	RBMS2	exon_skip_28336	-5.826869e-01	1.139202e-03
IFG	PABPN1L	exon_skip_28336	-4.327954e-01	2.142722e-02
IFG	DAZAP1	exon_skip_189459	4.741002e-01	1.081076e-02
IFG	RBM6	exon_skip_189459	4.564480e-01	1.462607e-02
IFG	UNK	exon_skip_189459	6.408408e-01	2.388048e-04
IFG	FUBP3	exon_skip_189459	4.070948e-01	3.155170e-02
IFG	RBM4B	exon_skip_189459	4.730656e-01	1.100868e-02
IFG	ELAVL4	exon_skip_293592	-5.849457e-01	1.077961e-03
IFG	TIA1	exon_skip_293592	4.042241e-01	3.288905e-02
IFG	PABPC5	exon_skip_293592	4.064605e-01	3.184335e-02
IFG	SRSF1	exon_skip_59154	4.447222e-01	1.773107e-02
IFG	RALYL	exon_skip_158407	-4.858725e-01	8.760450e-03
PCC	FUS	exon_skip_139426	-4.150082e-01	5.709913e-09
PCC	ZNF326	exon_skip_264227	-5.999465e-01	2.081696e-22
PCC	SFPQ	exon_skip_264227	-4.307307e-01	4.007109e-11
PCC	RBM6	exon_skip_264227	-4.686623e-01	3.878241e-13
PCC	SRSF11	exon_skip_264227	-4.145942e-01	2.436922e-10
PCC	TRNAU1AP	exon_skip_264227	-4.544536e-01	2.357322e-12
PCC	PCBP4	exon_skip_264227	-5.108332e-01	1.089289e-15
PCC	PTBP1	exon_skip_264227	-6.530618e-01	1.600490e-27
PCC	HNRNPF	exon_skip_264227	-5.701817e-01	6.174979e-20
PCC	PABPC1	exon_skip_102016	-4.859667e-01	3.835848e-14
PCC	PABPC1	exon_skip_190729	-4.567003e-01	5.212972e-12
PCC	RBMS2	exon_skip_59261	-6.479715e-01	5.477964e-27
PCC	RBM6	exon_skip_59261	-4.521286e-01	3.142372e-12
PCC	PCBP4	exon_skip_59261	-4.401256e-01	1.339414e-11
PCC	G3BP2	exon_skip_59261	5.984701e-01	2.799840e-22
PCC	PABPC1	exon_skip_59261	-4.469635e-01	5.905134e-12
PCC	RBMS2	exon_skip_243691	-6.660282e-01	6.639543e-28
PCC	RBMS3	exon_skip_243691	-4.914771e-01	5.497940e-14
PCC	MSI1	exon_skip_243691	-5.289586e-01	2.546728e-16
PCC	RBM6	exon_skip_243691	-4.616781e-01	2.528596e-12
PCC	PCBP4	exon_skip_243691	-5.170538e-01	1.508853e-15
PCC	G3BP2	exon_skip_243691	5.925327e-01	5.219019e-21
PCC	FUBP3	exon_skip_243691	-4.388251e-01	3.743164e-11
PCC	PABPC1	exon_skip_243691	-5.066910e-01	6.715713e-15
PCC	RBM3	exon_skip_202978	6.125901e-01	3.989426e-23
PCC	ELAVL4	exon_skip_50600	-4.198938e-01	1.833277e-10
PCC	PCBP4	exon_skip_50600	4.235824e-01	1.221918e-10
PCC	ELAVL4	exon_skip_293592	-5.081811e-01	1.879386e-15
PCC	PABPC1	exon_skip_293592	4.067292e-01	6.228499e-10
PG	PCBP1	exon_skip_264227	4.811357e-01	1.656348e-13
PG	KHDRBS2	exon_skip_102016	6.402016e-01	1.691074e-25
PG	KHDRBS3	exon_skip_102016	6.272169e-01	2.972944e-24
PG	ENOX1	exon_skip_102016	4.095228e-01	7.410947e-10
PG	HNRNPA0	exon_skip_102016	4.798504e-01	1.960889e-13
PG	RALYL	exon_skip_50600	-4.324956e-01	1.600633e-10
PG	ELAVL4	exon_skip_293592	-5.727211e-01	3.549810e-19
PG	RBM3	exon_skip_293592	-4.883068e-01	1.274655e-13
PG	RALYL	exon_skip_293592	-5.706154e-01	5.112412e-19
PG	RBM4	exon_skip_293592	-4.108054e-01	1.041073e-09
PG	MSI1	exon_skip_59154	4.339665e-01	5.228567e-11
PG	SRSF11	exon_skip_59154	-4.779789e-01	2.504031e-13
PG	RBM5	exon_skip_59154	-4.409505e-01	2.355582e-11
PG	HNRNPK	exon_skip_59154	-4.721808e-01	5.291171e-13
PG	TRA2A	exon_skip_59154	-4.039495e-01	1.317352e-09
PG	PCBP2	exon_skip_59154	-5.143081e-01	1.648659e-15
PG	RBM45	exon_skip_59154	-5.698172e-01	2.172417e-19
PG	RALYL	exon_skip_59154	-6.018302e-01	5.562192e-22
PG	EIF4G2	exon_skip_59154	-5.249107e-01	3.389045e-16
PG	HNRNPL	exon_skip_59154	-5.329912e-01	9.775043e-17
PG	SRSF1	exon_skip_59154	-5.193191e-01	7.859554e-16
PG	SRSF9	exon_skip_59154	-5.782498e-01	4.804885e-20
PG	NOVA1	exon_skip_59154	-5.636432e-01	6.381728e-19
PG	RBM4	exon_skip_59154	-5.023927e-01	9.147452e-15
PG	IGF2BP2	exon_skip_158407	4.307637e-01	2.377936e-10
PG	HNRNPK	exon_skip_158407	-4.326405e-01	1.948233e-10
PG	ENOX1	exon_skip_158407	-4.449977e-01	5.085081e-11
PG	NUP42	exon_skip_158407	-4.025546e-01	4.121991e-09
PG	RALYL	exon_skip_158407	-6.447144e-01	1.192164e-24
STG	MSI1	exon_skip_272794	-4.321865e-01	1.692741e-05
STG	HNRNPH2	exon_skip_68438	4.620368e-01	3.130415e-06
STG	KHDRBS2	exon_skip_101915	4.737453e-01	5.874952e-05
STG	KHDRBS3	exon_skip_101915	4.193279e-01	4.573673e-04
STG	KHDRBS2	exon_skip_102016	5.456680e-01	1.854400e-08
STG	KHDRBS3	exon_skip_102016	5.955079e-01	3.818740e-10
STG	HNRNPA0	exon_skip_102016	6.064552e-01	1.485471e-10
STG	HNRNPDL	exon_skip_102016	4.404211e-01	1.116132e-05
STG	NUP42	exon_skip_102016	4.225951e-01	2.712849e-05
STG	SRSF9	exon_skip_102016	4.061358e-01	5.898979e-05
STG	ELAVL4	exon_skip_50600	-4.071589e-01	8.254743e-05
STG	RALYL	exon_skip_50600	-4.320270e-01	2.633518e-05
STG	ELAVL4	exon_skip_293592	-5.086227e-01	2.261504e-07
STG	NUP42	exon_skip_293592	-4.159153e-01	3.736455e-05
STG	RALYL	exon_skip_293592	-5.437281e-01	2.129966e-08
STG	RALYL	exon_skip_59154	-4.690948e-01	2.107506e-06
STG	MBNL1	exon_skip_158407	-4.790230e-01	1.362462e-06
STG	HNRNPK	exon_skip_158407	-5.165050e-01	1.361477e-07
STG	FUBP1	exon_skip_158407	-4.761122e-01	1.611179e-06
STG	NUP42	exon_skip_158407	-5.235642e-01	8.547742e-08
STG	RALYL	exon_skip_158407	-6.421415e-01	5.247783e-12
STG	SRSF1	exon_skip_158407	-4.505720e-01	6.579474e-06
TC	SRSF2	exon_skip_209242	4.961861e-01	2.520762e-11
TC	MATR3	exon_skip_209242	7.068504e-01	1.561034e-25
TC	FXR2	exon_skip_209242	5.174877e-01	2.437492e-12
TC	ILF2	exon_skip_209242	4.825672e-01	1.033801e-10
TC	KHDRBS2	exon_skip_209242	8.005871e-01	5.691592e-37
TC	KHDRBS3	exon_skip_209242	7.171271e-01	1.475417e-26
TC	RBM24	exon_skip_209242	7.709749e-01	8.965933e-33
TC	ENOX1	exon_skip_209242	4.329897e-01	1.074651e-08
TC	PUM1	exon_skip_209242	6.113603e-01	8.987401e-18
TC	HNRNPDL	exon_skip_209242	4.300347e-01	1.385426e-08
TC	RBM45	exon_skip_209242	5.073796e-01	7.536161e-12
TC	HNRNPD	exon_skip_209242	5.465475e-01	7.653291e-14
TC	NUP42	exon_skip_209242	6.448072e-01	3.535990e-20
TC	RALYL	exon_skip_209242	8.062324e-01	7.487632e-38
TC	PTBP1	exon_skip_209242	-4.200212e-01	3.218361e-08
TC	PTBP3	exon_skip_209242	4.077041e-01	8.746679e-08
TC	CELF1	exon_skip_209242	5.650157e-01	7.090022e-15
TC	SRSF5	exon_skip_209242	4.422637e-01	4.765694e-09
TC	HNRNPH2	exon_skip_209242	6.331116e-01	2.647966e-19
TC	YBX2	exon_skip_209242	4.636445e-01	6.645248e-10
TC	ESRP1	exon_skip_209242	6.211394e-01	1.906336e-18
TC	NOVA1	exon_skip_209242	6.503786e-01	1.313647e-20
TC	KHDRBS2	exon_skip_101915	7.710323e-01	1.110273e-24
TC	KHDRBS3	exon_skip_101915	6.994624e-01	8.886507e-19
TC	ENOX1	exon_skip_101915	4.088771e-01	3.898921e-06
TC	HNRNPA0	exon_skip_101915	6.460142e-01	2.131845e-15
TC	HNRNPDL	exon_skip_101915	4.046316e-01	5.014599e-06
TC	HNRNPD	exon_skip_101915	5.239432e-01	9.664489e-10
TC	NUP42	exon_skip_101915	5.796438e-01	4.944830e-12
TC	CNOT4	exon_skip_102016	4.694218e-01	3.810712e-10
TC	KHDRBS2	exon_skip_102016	8.598504e-01	5.445866e-48
TC	KHDRBS3	exon_skip_102016	7.907708e-01	1.665657e-35
TC	ENOX1	exon_skip_102016	4.969208e-01	2.331815e-11
TC	HNRNPA0	exon_skip_102016	7.568104e-01	5.544450e-31
TC	HNRNPDL	exon_skip_102016	5.264492e-01	8.681971e-13
TC	HNRNPD	exon_skip_102016	6.552067e-01	5.476226e-21
TC	NUP42	exon_skip_102016	7.471457e-01	7.891389e-30
TC	PTBP3	exon_skip_102016	5.233989e-01	1.237926e-12
TC	SRSF9	exon_skip_102016	4.700858e-01	3.572400e-10
TC	SART3	exon_skip_102016	4.480637e-01	2.830252e-09
TC	CNOT4	exon_skip_190729	5.137845e-01	1.854546e-10
TC	KHDRBS2	exon_skip_190729	6.561007e-01	5.754648e-18
TC	KHDRBS3	exon_skip_190729	6.651025e-01	1.395767e-18
TC	ENOX1	exon_skip_190729	4.729018e-01	6.970002e-09
TC	HNRNPA0	exon_skip_190729	6.699907e-01	6.334878e-19
TC	HNRNPDL	exon_skip_190729	5.318780e-01	3.175857e-11
TC	HNRNPD	exon_skip_190729	6.387309e-01	7.759591e-17
TC	NUP42	exon_skip_190729	5.549589e-01	2.856916e-12
TC	PTBP3	exon_skip_190729	5.775574e-01	2.243680e-13
TC	SRSF9	exon_skip_190729	4.952507e-01	1.018572e-09
TC	SART3	exon_skip_190729	5.261802e-01	5.598792e-11
TC	CNOT4	exon_skip_59261	4.146204e-01	5.013860e-08
TC	G3BP2	exon_skip_59261	6.728285e-01	1.953095e-22
TC	KHDRBS2	exon_skip_59261	7.609652e-01	1.703548e-31
TC	KHDRBS3	exon_skip_59261	6.653955e-01	8.191696e-22
TC	ENOX1	exon_skip_59261	4.738871e-01	2.461718e-10
TC	HNRNPA0	exon_skip_59261	6.322338e-01	3.069329e-19
TC	HNRNPDL	exon_skip_59261	4.326558e-01	1.106080e-08
TC	HNRNPD	exon_skip_59261	5.689291e-01	4.201248e-15
TC	NUP42	exon_skip_59261	6.698532e-01	3.484305e-22
TC	PTBP3	exon_skip_59261	4.713162e-01	3.168330e-10
TC	RBM3	exon_skip_181562	4.064211e-01	5.715560e-07
TC	RBM3	exon_skip_138926	5.769288e-01	3.940645e-15
TC	RBM3	exon_skip_141124	4.970723e-01	7.320865e-11
TC	ELAVL4	exon_skip_50600	-6.297766e-01	7.719400e-19
TC	NUP42	exon_skip_50600	-4.094695e-01	9.182975e-08
TC	RALYL	exon_skip_50600	-5.727361e-01	3.755981e-15
TC	ELAVL4	exon_skip_293592	-5.957954e-01	1.485392e-16
TC	RBM3	exon_skip_293592	-4.007341e-01	1.813620e-07
TC	NUP42	exon_skip_293592	-4.456512e-01	4.418329e-09
TC	RALYL	exon_skip_293592	-5.669433e-01	8.131471e-15
TC	FUBP1	exon_skip_199765	-4.222740e-01	2.953040e-08
TC	NUP42	exon_skip_199765	-4.475328e-01	3.330925e-09
TC	RALYL	exon_skip_199765	-5.005563e-01	1.832412e-11
TC	SRSF5	exon_skip_199765	-4.259165e-01	2.179414e-08

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RelatedDrugs for SORBS1

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SORBS1

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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