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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for NCOA2 |
 Gene summary |
| Gene information | Gene symbol | NCOA2 | Gene ID | 10499 |
| Gene name | nuclear receptor coactivator 2 | |
| Synonyms | GRIP1|KAT13C|NCoA-2|SRC2|TIF2|bHLHe75 | |
| Cytomap | 8q13.3 | |
| Type of gene | protein-coding | |
| Description | nuclear receptor coactivator 2class E basic helix-loop-helix protein 75glucocorticoid receptor-interacting protein-1p160 steroid receptor coactivator 2transcriptional intermediary factor 2 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for NCOA2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000140396
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000521239.1 | NCOA2-206:retained_intron:NCOA2 | 1.169059e+01 | 1.085178e+00 | 5.114911e-10 | 2.516571e-08 |
| CB | UP | ENST00000518363.2 | NCOA2-203:protein_coding:NCOA2 | 2.192242e+01 | 1.044884e+00 | 1.486582e-05 | 1.475471e-04 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NCOA2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_138415 | chr8 | 70113569:70113643:70121302:70121391:70123884:70124082 | 70121302:70121391 |
| exon_skip_191610 | chr8 | 70174756:70174859:70213903:70214075:70216660:70216764 | 70213903:70214075 |
| exon_skip_248138 | chr8 | 70170202:70170379:70174756:70174859:70213903:70214075 | 70174756:70174859 |
| exon_skip_37096 | chr8 | 70141184:70141399:70148273:70148483:70155971:70156636 | 70148273:70148483 |
| exon_skip_68225 | chr8 | 70141184:70141399:70148273:70148483:70155971:70156640 | 70148273:70148483 |
| exon_skip_72857 | chr8 | 70141184:70141399:70144642:70144848:70148273:70148460 | 70144642:70144848 |
| exon_skip_89786 | chr8 | 70162711:70162854:70163465:70163566:70166566:70166754 | 70163465:70163566 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for NCOA2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000452400 | 70174756 | 70174859 | Frame-shift |
| ENST00000452400 | 70213903 | 70214075 | Frame-shift |
| ENST00000452400 | 70144642 | 70144848 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000452400 | 70174756 | 70174859 | Frame-shift |
| ENST00000452400 | 70144642 | 70144848 | In-frame |
| ENST00000452400 | 70163465 | 70163566 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000452400 | 70174756 | 70174859 | Frame-shift |
| ENST00000452400 | 70213903 | 70214075 | Frame-shift |
| ENST00000452400 | 70121302 | 70121391 | In-frame |
| ENST00000452400 | 70144642 | 70144848 | In-frame |
| ENST00000452400 | 70163465 | 70163566 | In-frame |
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Infer the effects of exon skipping event on protein functional features for NCOA2 |
p-ENSG00000140396_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000452400 | 8464 | 1464 | 70144642 | 70144848 | 2788 | 2993 | 868 | 937 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000452400 | 8464 | 1464 | 70163465 | 70163566 | 913 | 1013 | 243 | 277 |
| ENST00000452400 | 8464 | 1464 | 70144642 | 70144848 | 2788 | 2993 | 868 | 937 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000452400 | 8464 | 1464 | 70163465 | 70163566 | 913 | 1013 | 243 | 277 |
| ENST00000452400 | 8464 | 1464 | 70144642 | 70144848 | 2788 | 2993 | 868 | 937 |
| ENST00000452400 | 8464 | 1464 | 70121302 | 70121391 | 4476 | 4564 | 1431 | 1460 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q15596 | 868 | 937 | 2 | 1464 | Chain | ID=PRO_0000094402;Note=Nuclear receptor coactivator 2 |
| Q15596 | 868 | 937 | 874 | 874 | Modified residue | Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61026 |
| Q15596 | 868 | 937 | 878 | 882 | Motif | Note=LXXLL motif 4 |
| Q15596 | 868 | 937 | 730 | 1121 | Region | Note=Interaction with ARNTL;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61026 |
| Q15596 | 868 | 937 | 869 | 870 | Site | Note=Breakpoint for translocation to form KAT6A-NCOA2;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12676584,ECO:0000269|PubMed:15657427,ECO:0000269|PubMed:9558366;Dbxref=PMID:12676584,PMID:15657427,PMID:9558366 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q15596 | 243 | 277 | 2 | 1464 | Chain | ID=PRO_0000094402;Note=Nuclear receptor coactivator 2 |
| Q15596 | 868 | 937 | 2 | 1464 | Chain | ID=PRO_0000094402;Note=Nuclear receptor coactivator 2 |
| Q15596 | 868 | 937 | 874 | 874 | Modified residue | Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61026 |
| Q15596 | 868 | 937 | 878 | 882 | Motif | Note=LXXLL motif 4 |
| Q15596 | 868 | 937 | 730 | 1121 | Region | Note=Interaction with ARNTL;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61026 |
| Q15596 | 868 | 937 | 869 | 870 | Site | Note=Breakpoint for translocation to form KAT6A-NCOA2;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12676584,ECO:0000269|PubMed:15657427,ECO:0000269|PubMed:9558366;Dbxref=PMID:12676584,PMID:15657427,PMID:9558366 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q15596 | 243 | 277 | 2 | 1464 | Chain | ID=PRO_0000094402;Note=Nuclear receptor coactivator 2 |
| Q15596 | 868 | 937 | 2 | 1464 | Chain | ID=PRO_0000094402;Note=Nuclear receptor coactivator 2 |
| Q15596 | 868 | 937 | 874 | 874 | Modified residue | Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61026 |
| Q15596 | 868 | 937 | 878 | 882 | Motif | Note=LXXLL motif 4 |
| Q15596 | 868 | 937 | 730 | 1121 | Region | Note=Interaction with ARNTL;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61026 |
| Q15596 | 868 | 937 | 869 | 870 | Site | Note=Breakpoint for translocation to form KAT6A-NCOA2;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12676584,ECO:0000269|PubMed:15657427,ECO:0000269|PubMed:9558366;Dbxref=PMID:12676584,PMID:15657427,PMID:9558366 |
| Q15596 | 1431 | 1460 | 2 | 1464 | Chain | ID=PRO_0000094402;Note=Nuclear receptor coactivator 2 |
| Q15596 | 1431 | 1460 | 1454 | 1454 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
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3'-UTR located exon skipping events that lost miRNA binding sites in NCOA2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for NCOA2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for NCOA2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| ADstage | MSBB | IFG | exon_skip_72857 | -3.749565e-01 | 4.929581e-02 | chr8 | - | 70141184 | 70141399 | 70144642 | 70144848 | 70148273 | 70148460 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NCOA2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| HCC | exon_skip_248138 | rs4236979 | chr8:70123253 | 4.014884e-04 | 2.847546e-02 |
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Correlation with RNA binding proteins (RBPs) for NCOA2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RC3H1 | exon_skip_248138 | -4.241301e-01 | 1.125726e-06 |
| CB | FUBP1 | exon_skip_248138 | -4.828605e-01 | 1.774542e-08 |
| HCC | PCBP4 | exon_skip_72857 | -4.258233e-01 | 7.089165e-13 |
| IFG | IGF2BP2 | exon_skip_72857 | -4.270392e-01 | 2.342451e-02 |
| IFG | KHDRBS3 | exon_skip_72857 | 4.834119e-01 | 9.159552e-03 |
| IFG | NOVA1 | exon_skip_72857 | 4.618134e-01 | 1.336373e-02 |
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RelatedDrugs for NCOA2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q15596 | approved|investigational | DB00255 | Diethylstilbestrol | small molecule | Q15596 |
| Q15596 | approved|investigational|vet_approved | DB00783 | Estradiol | small molecule | Q15596 |
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RelatedDiseases for NCOA2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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