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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for EIF3M |
 Gene summary |
| Gene information | Gene symbol | EIF3M | Gene ID | 10480 |
| Gene name | eukaryotic translation initiation factor 3 subunit M | |
| Synonyms | B5|GA17|PCID1|TANGO7|hfl-B5 | |
| Cytomap | 11p13 | |
| Type of gene | protein-coding | |
| Description | eukaryotic translation initiation factor 3 subunit MB5 receptorPCI domain containing 1 (herpesvirus entry mediator)PCI domain-containing protein 1dendritic cell proteinfetal lung protein B5transport and golgi organization 7 homolog | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for EIF3M |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000149100
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for EIF3M |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_132956 | chr11 | 32594914:32595013:32595966:32596047:32600689:32600793 | 32595966:32596047 |
| exon_skip_139762 | chr11 | 32587103:32587144:32588594:32588732:32589547:32589603 | 32588594:32588732 |
| exon_skip_151817 | chr11 | 32601762:32601822:32602079:32602114:32602279:32602377 | 32602079:32602114 |
| exon_skip_155225 | chr11 | 32601763:32601822:32602079:32602114:32602279:32602302 | 32602079:32602114 |
| exon_skip_159571 | chr11 | 32583884:32583929:32587046:32587144:32588594:32588681 | 32587046:32587144 |
| exon_skip_165202 | chr11 | 32583884:32583929:32589547:32589641:32593866:32593949 | 32589547:32589641 |
| exon_skip_172944 | chr11 | 32587046:32587144:32588594:32588732:32589547:32589641 | 32588594:32588732 |
| exon_skip_197576 | chr11 | 32588683:32588732:32589012:32589135:32589547:32589641 | 32589012:32589135 |
| exon_skip_198422 | chr11 | 32587046:32587144:32589547:32589641:32593866:32593949 | 32589547:32589641 |
| exon_skip_203939 | chr11 | 32593866:32593949:32594914:32595013:32595966:32596010 | 32594914:32595013 |
| exon_skip_206252 | chr11 | 32588594:32588732:32589012:32589135:32589547:32589603 | 32589012:32589135 |
| exon_skip_234769 | chr11 | 32583884:32583929:32587012:32587144:32588594:32588681 | 32587012:32587144 |
| exon_skip_280819 | chr11 | 32587046:32587144:32588594:32588732:32589547:32589603 | 32588594:32588732 |
| exon_skip_286299 | chr11 | 32583884:32583929:32587012:32587144:32589547:32589641 | 32587012:32587144 |
| exon_skip_290044 | chr11 | 32588594:32588732:32589012:32589135:32589547:32589641 | 32589012:32589135 |
| exon_skip_31552 | chr11 | 32583884:32583929:32587012:32587144:32589547:32589603 | 32587012:32587144 |
| exon_skip_61649 | chr11 | 32583884:32583929:32586934:32587144:32588594:32588681 | 32586934:32587144 |
| exon_skip_8751 | chr11 | 32601769:32601822:32602079:32602114:32602279:32602302 | 32602079:32602114 |
| exon_skip_91420 | chr11 | 32601762:32601822:32602079:32602114:32602279:32602302 | 32602079:32602114 |
| exon_skip_94028 | chr11 | 32588594:32588732:32589547:32589641:32593866:32593949 | 32589547:32589641 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_165202 | Mayo_CB | 5.537975e-01 | 7.437097e-01 | -1.899122e-01 | 8.397816e-08 |
| exon_skip_165202 | Mayo_TC | 7.504225e-01 | 8.588525e-01 | -1.084299e-01 | 2.944284e-04 |
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Open reading frame (ORF) annotation in the exon skipping event for EIF3M |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000531120 | 32587012 | 32587144 | Frame-shift |
| ENST00000531120 | 32589012 | 32589135 | Frame-shift |
| ENST00000531120 | 32594914 | 32595013 | Frame-shift |
| ENST00000531120 | 32595966 | 32596047 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000531120 | 32587012 | 32587144 | Frame-shift |
| ENST00000531120 | 32589012 | 32589135 | Frame-shift |
| ENST00000531120 | 32594914 | 32595013 | Frame-shift |
| ENST00000531120 | 32595966 | 32596047 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000531120 | 32587012 | 32587144 | Frame-shift |
| ENST00000531120 | 32589012 | 32589135 | Frame-shift |
| ENST00000531120 | 32594914 | 32595013 | Frame-shift |
| ENST00000531120 | 32595966 | 32596047 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for EIF3M |
p-ENSG00000149100_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in EIF3M |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for EIF3M |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for EIF3M |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for EIF3M |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for EIF3M |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TARDBP | exon_skip_219431 | 4.442294e-01 | 1.338374e-07 |
| CB | CNOT4 | exon_skip_219431 | 4.011440e-01 | 2.462815e-06 |
| CB | TARDBP | exon_skip_165202 | -4.528177e-01 | 1.723268e-08 |
| CB | RBM6 | exon_skip_165202 | -4.998357e-01 | 2.788594e-10 |
| CB | TRA2A | exon_skip_165202 | -6.145521e-01 | 5.252790e-16 |
| CB | HNRNPAB | exon_skip_165202 | -4.189732e-01 | 2.332757e-07 |
| CB | NUP42 | exon_skip_165202 | 5.139063e-01 | 7.152975e-11 |
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RelatedDrugs for EIF3M |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EIF3M |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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