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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for VAV3 |
 Gene summary |
| Gene information | Gene symbol | VAV3 | Gene ID | 10451 |
| Gene name | vav guanine nucleotide exchange factor 3 | |
| Synonyms | - | |
| Cytomap | 1p13.3 | |
| Type of gene | protein-coding | |
| Description | guanine nucleotide exchange factor VAV3VAV-3vav 3 guanine nucleotide exchange factorvav 3 oncogene | |
| Modification date | 20200320 | |
| UniProtAcc | ||
| Context | - 31707550(BBB-permeable Aporphine-Type Alkaloids in Nelumbo Nucifera Flowers With Accelerative Effects on Neurite Outgrowth in PC-12 Cells) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for VAV3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000134215
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| DLPFC | UP | ENST00000469325.5 | VAV3-204:lncRNA:VAV3 | 4.679010e+00 | 9.169102e-01 | 1.304096e-05 | 1.714752e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for VAV3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_121536 | chr1 | 107704960:107705061:107748968:107749077:107749462:107749508 | 107748968:107749077 |
| exon_skip_125168 | chr1 | 107642619:107642755:107683488:107683533:107688381:107688504 | 107683488:107683533 |
| exon_skip_182113 | chr1 | 107603097:107603163:107609424:107609539:107609931:107609965 | 107609424:107609539 |
| exon_skip_188276 | chr1 | 107755427:107755513:107757261:107757329:107760784:107760879 | 107757261:107757329 |
| exon_skip_230317 | chr1 | 107779434:107779492:107874901:107875017:107964666:107964853 | 107874901:107875017 |
| exon_skip_267491 | chr1 | 107642619:107642755:107672144:107672261:107683488:107683533 | 107672144:107672261 |
| exon_skip_287798 | chr1 | 107770659:107770728:107772735:107772843:107777231:107777296 | 107772735:107772843 |
| exon_skip_294591 | chr1 | 107668963:107669472:107683488:107683533:107688381:107688406 | 107683488:107683533 |
| exon_skip_3240 | chr1 | 107574047:107574198:107576392:107576475:107596212:107596341 | 107576392:107576475 |
| exon_skip_62943 | chr1 | 107669160:107669472:107683488:107683533:107688381:107688406 | 107683488:107683533 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for VAV3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370056 | 107683488 | 107683533 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370056 | 107772735 | 107772843 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370056 | 107683488 | 107683533 | Frame-shift |
| ENST00000370056 | 107748968 | 107749077 | Frame-shift |
| ENST00000370056 | 107757261 | 107757329 | In-frame |
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Infer the effects of exon skipping event on protein functional features for VAV3 |
p-ENSG00000134215_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000370056 | 5007 | 847 | 107757261 | 107757329 | 1293 | 1360 | 339 | 361 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UKW4 | 339 | 361 | 1 | 560 | Alternative sequence | ID=VSP_041360;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:9705494;Dbxref=PMID:14702039,PMID:9705494 |
| Q9UKW4 | 339 | 361 | 1 | 847 | Chain | ID=PRO_0000080986;Note=Guanine nucleotide exchange factor VAV3 |
| Q9UKW4 | 339 | 361 | 192 | 371 | Domain | Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062 |
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3'-UTR located exon skipping events that lost miRNA binding sites in VAV3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for VAV3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for VAV3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for VAV3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for VAV3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for VAV3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for VAV3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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