|
Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for MCRS1 |
Gene summary |
Gene information | Gene symbol | MCRS1 | Gene ID | 10445 |
Gene name | microspherule protein 1 | |
Synonyms | ICP22BP|INO80Q|MCRS2|MSP58|P78 | |
Cytomap | 12q13.12 | |
Type of gene | protein-coding | |
Description | microspherule protein 158 kDa microspherule proteinINO80 complex subunit JINO80 complex subunit Qcell cycle-regulated factor (78 kDa)cell cycle-regulated factor p78 | |
Modification date | 20200320 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
MCRS1 | GO:0043981 | histone H4-K5 acetylation | 20018852 |
MCRS1 | GO:0043982 | histone H4-K8 acetylation | 20018852 |
MCRS1 | GO:0043984 | histone H4-K16 acetylation | 20018852 |
MCRS1 | GO:1904751 | positive regulation of protein localization to nucleolus | 16571602 |
Top |
Gene structures and expression levels for MCRS1 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | DOWN | ENST00000552596.1 | MCRS1-215:retained_intron:MCRS1 | 3.145235e+01 | -9.634762e-01 | 7.214296e-13 | 1.128350e-10 |
CB | DOWN | ENST00000548602.5 | MCRS1-207:nonsense_mediated_decay:MCRS1 | 1.226177e+02 | -1.489314e+00 | 5.834773e-04 | 3.284218e-03 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MCRS1 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_131411 | chr12 | 49565530:49565667:49566077:49566841:49568048:49568100 | 49566077:49566841 |
exon_skip_155524 | chr12 | 49566722:49566841:49567647:49567749:49568048:49568100 | 49567647:49567749 |
exon_skip_170366 | chr12 | 49565530:49565667:49566077:49566215:49568048:49568100 | 49566077:49566215 |
exon_skip_194847 | chr12 | 49566077:49566215:49566722:49566841:49568048:49568100 | 49566722:49566841 |
exon_skip_196795 | chr12 | 49563487:49563546:49564481:49564590:49564737:49564895 | 49564481:49564590 |
exon_skip_238395 | chr12 | 49558843:49558970:49559214:49559301:49559453:49559535 | 49559214:49559301 |
exon_skip_254748 | chr12 | 49558843:49558970:49559214:49559332:49559453:49559535 | 49559214:49559332 |
exon_skip_292334 | chr12 | 49566077:49566215:49566722:49566841:49567647:49567749 | 49566722:49566841 |
exon_skip_293072 | chr12 | 49566740:49566841:49567647:49567749:49568048:49568100 | 49567647:49567749 |
exon_skip_44044 | chr12 | 49565530:49565667:49566077:49566215:49566722:49566841 | 49566077:49566215 |
exon_skip_99122 | chr12 | 49559214:49559301:49559453:49559535:49559729:49559780 | 49559453:49559535 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Top |
Open reading frame (ORF) annotation in the exon skipping event for MCRS1 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000343810 | 49566722 | 49566841 | 3UTR-3CDS |
ENST00000550165 | 49567647 | 49567749 | 3UTR-3UTR |
ENST00000343810 | 49559214 | 49559301 | Frame-shift |
ENST00000550165 | 49559214 | 49559301 | Frame-shift |
ENST00000343810 | 49559453 | 49559535 | Frame-shift |
ENST00000550165 | 49559453 | 49559535 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000343810 | 49566722 | 49566841 | 3UTR-3CDS |
ENST00000550165 | 49567647 | 49567749 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000343810 | 49566722 | 49566841 | 3UTR-3CDS |
ENST00000550165 | 49566722 | 49566841 | 3UTR-3CDS |
ENST00000550165 | 49567647 | 49567749 | 3UTR-3UTR |
ENST00000343810 | 49559453 | 49559535 | Frame-shift |
ENST00000550165 | 49559453 | 49559535 | Frame-shift |
ENST00000343810 | 49564481 | 49564590 | Frame-shift |
ENST00000550165 | 49564481 | 49564590 | Frame-shift |
ENST00000343810 | 49566077 | 49566215 | Frame-shift |
ENST00000550165 | 49566077 | 49566215 | Frame-shift |
Top |
Infer the effects of exon skipping event on protein functional features for MCRS1 |
p-ENSG00000187778_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in MCRS1 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000550165 | 49567647 | 49567749 | hsa-miR-30c-1-3p | chr12:49567666-49567673 | 8mer-1a | chr12:49567652-49567673 | 166.00 | -25.40 |
Mayo | ENST00000550165 | 49567647 | 49567749 | hsa-miR-6878-5p | chr12:49567665-49567672 | 8mer-1a | chr12:49567652-49567673 | 166.00 | -25.40 |
Mayo | ENST00000550165 | 49567647 | 49567749 | hsa-miR-4524a-3p | chr12:49567708-49567715 | 8mer-1a | chr12:49567694-49567715 | 160.00 | -24.47 |
Mayo | ENST00000550165 | 49567647 | 49567749 | hsa-miR-6788-5p | chr12:49567666-49567673 | 8mer-1a | chr12:49567652-49567673 | 166.00 | -25.40 |
Mayo | ENST00000550165 | 49567647 | 49567749 | hsa-miR-526b-5p | chr12:49567712-49567719 | 8mer-1a | chr12:49567698-49567719 | 147.00 | -16.35 |
Mayo | ENST00000550165 | 49567647 | 49567749 | hsa-miR-6813-3p | chr12:49567684-49567691 | 8mer-1a | chr12:49567678-49567703 | 162.00 | -26.06 |
Mayo | ENST00000550165 | 49567647 | 49567749 | hsa-miR-4455 | chr12:49567679-49567686 | 8mer-1a | chr12:49567678-49567703 | 162.00 | -26.06 |
Mayo | ENST00000550165 | 49567647 | 49567749 | hsa-miR-30c-2-3p | chr12:49567666-49567673 | 8mer-1a | chr12:49567652-49567673 | 166.00 | -25.40 |
MSBB | ENST00000550165 | 49567647 | 49567749 | hsa-miR-30c-1-3p | chr12:49567666-49567673 | 8mer-1a | chr12:49567652-49567673 | 166.00 | -25.40 |
MSBB | ENST00000550165 | 49567647 | 49567749 | hsa-miR-6878-5p | chr12:49567665-49567672 | 8mer-1a | chr12:49567652-49567673 | 166.00 | -25.40 |
MSBB | ENST00000550165 | 49567647 | 49567749 | hsa-miR-4524a-3p | chr12:49567708-49567715 | 8mer-1a | chr12:49567694-49567715 | 160.00 | -24.47 |
MSBB | ENST00000550165 | 49567647 | 49567749 | hsa-miR-6788-5p | chr12:49567666-49567673 | 8mer-1a | chr12:49567652-49567673 | 166.00 | -25.40 |
MSBB | ENST00000550165 | 49567647 | 49567749 | hsa-miR-526b-5p | chr12:49567712-49567719 | 8mer-1a | chr12:49567698-49567719 | 147.00 | -16.35 |
MSBB | ENST00000550165 | 49567647 | 49567749 | hsa-miR-6813-3p | chr12:49567684-49567691 | 8mer-1a | chr12:49567678-49567703 | 162.00 | -26.06 |
MSBB | ENST00000550165 | 49567647 | 49567749 | hsa-miR-4455 | chr12:49567679-49567686 | 8mer-1a | chr12:49567678-49567703 | 162.00 | -26.06 |
MSBB | ENST00000550165 | 49567647 | 49567749 | hsa-miR-30c-2-3p | chr12:49567666-49567673 | 8mer-1a | chr12:49567652-49567673 | 166.00 | -25.40 |
ROSMAP | ENST00000550165 | 49567647 | 49567749 | hsa-miR-30c-1-3p | chr12:49567666-49567673 | 8mer-1a | chr12:49567652-49567673 | 166.00 | -25.40 |
ROSMAP | ENST00000550165 | 49567647 | 49567749 | hsa-miR-6878-5p | chr12:49567665-49567672 | 8mer-1a | chr12:49567652-49567673 | 166.00 | -25.40 |
ROSMAP | ENST00000550165 | 49567647 | 49567749 | hsa-miR-4524a-3p | chr12:49567708-49567715 | 8mer-1a | chr12:49567694-49567715 | 160.00 | -24.47 |
ROSMAP | ENST00000550165 | 49567647 | 49567749 | hsa-miR-6788-5p | chr12:49567666-49567673 | 8mer-1a | chr12:49567652-49567673 | 166.00 | -25.40 |
ROSMAP | ENST00000550165 | 49567647 | 49567749 | hsa-miR-526b-5p | chr12:49567712-49567719 | 8mer-1a | chr12:49567698-49567719 | 147.00 | -16.35 |
ROSMAP | ENST00000550165 | 49567647 | 49567749 | hsa-miR-6813-3p | chr12:49567684-49567691 | 8mer-1a | chr12:49567678-49567703 | 162.00 | -26.06 |
ROSMAP | ENST00000550165 | 49567647 | 49567749 | hsa-miR-4455 | chr12:49567679-49567686 | 8mer-1a | chr12:49567678-49567703 | 162.00 | -26.06 |
ROSMAP | ENST00000550165 | 49567647 | 49567749 | hsa-miR-30c-2-3p | chr12:49567666-49567673 | 8mer-1a | chr12:49567652-49567673 | 166.00 | -25.40 |
Top |
SNVs in the skipped exons for MCRS1 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for MCRS1 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MCRS1 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for MCRS1 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
Top |
RelatedDrugs for MCRS1 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MCRS1 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |