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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for CPQ |
Gene summary |
Gene information | Gene symbol | CPQ | Gene ID | 10404 |
Gene name | carboxypeptidase Q | |
Synonyms | LDP|PGCP | |
Cytomap | 8q22.1 | |
Type of gene | protein-coding | |
Description | carboxypeptidase QSer-Met dipeptidaseaminopeptidaseblood plasma glutamate carboxypeptidaselysosomal dipeptidase | |
Modification date | 20200313 | |
UniProtAcc | ||
Context | - 26386394(Modulation of BV-2 Microglia Functions by Novel Quercetin Pivaloyl Ester) |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
CPQ | GO:0006508 | proteolysis | 10206990 |
CPQ | GO:0043171 | peptide catabolic process | 10206990 |
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Gene structures and expression levels for CPQ |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | DOWN | ENST00000522617.3 | CPQ-206:protein_coding:CPQ | 2.295843e+00 | -2.778871e+00 | 7.337166e-03 | 2.696908e-02 |
TC | DOWN | ENST00000522617.3 | CPQ-206:protein_coding:CPQ | 1.555587e+00 | -3.274446e+00 | 3.484838e-03 | 2.555999e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CPQ |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_119356 | chr8 | 96834973:96835180:96879798:96880005:96965935:96966046 | 96879798:96880005 |
exon_skip_133965 | chr8 | 96645375:96645402:96659284:96659323:96784864:96785287 | 96659284:96659323 |
exon_skip_165287 | chr8 | 97029469:97029494:97066009:97066210:97143020:97143188 | 97066009:97066210 |
exon_skip_242496 | chr8 | 96784864:96785330:96834973:96835180:96879798:96880005 | 96834973:96835180 |
exon_skip_31917 | chr8 | 96645375:96645402:96680443:96680547:96784864:96785287 | 96680443:96680547 |
exon_skip_41998 | chr8 | 97055529:97055645:97056406:97056545:97066009:97066210 | 97056406:97056545 |
exon_skip_68462 | chr8 | 96645375:96645402:96659284:96659323:96784864:96785252 | 96659284:96659323 |
exon_skip_91740 | chr8 | 96784864:96785330:96834973:96835180:96879798:96879810 | 96834973:96835180 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CPQ |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000220763 | 96834973 | 96835180 | Frame-shift |
ENST00000220763 | 96879798 | 96880005 | Frame-shift |
ENST00000220763 | 97066009 | 97066210 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000220763 | 96834973 | 96835180 | Frame-shift |
ENST00000220763 | 96879798 | 96880005 | Frame-shift |
ENST00000220763 | 97066009 | 97066210 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000220763 | 96834973 | 96835180 | Frame-shift |
ENST00000220763 | 96879798 | 96880005 | Frame-shift |
ENST00000220763 | 97066009 | 97066210 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for CPQ |
p-ENSG00000104324_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in CPQ |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CPQ |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CPQ |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CPQ |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CPQ |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for CPQ |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Q9Y646 | approved|nutraceutical | DB00142 | Glutamic Acid | small molecule | Q9Y646 |
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RelatedDiseases for CPQ |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |