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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for FSTL3 |
Gene summary |
Gene information | Gene symbol | FSTL3 | Gene ID | 10272 |
Gene name | follistatin like 3 | |
Synonyms | FLRG|FSRP | |
Cytomap | 19p13.3 | |
Type of gene | protein-coding | |
Description | follistatin-related protein 3follistatin-like 3 (secreted glycoprotein)follistatin-like protein 3follistatin-related gene protein | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
FSTL3 | GO:0002244 | hematopoietic progenitor cell differentiation | 15451575 |
FSTL3 | GO:0006357 | regulation of transcription by RNA polymerase II | 11948405 |
FSTL3 | GO:0022409 | positive regulation of cell-cell adhesion | 16336961 |
FSTL3 | GO:0030514 | negative regulation of BMP signaling pathway | 17878677 |
FSTL3 | GO:0032926 | negative regulation of activin receptor signaling pathway | 11948405|12697670 |
FSTL3 | GO:0045671 | negative regulation of osteoclast differentiation | 15574124 |
FSTL3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17868029 |
FSTL3 | GO:0090101 | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 17878677 |
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Gene structures and expression levels for FSTL3 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
PG | UP | ENST00000166139.9 | FSTL3-201:protein_coding:FSTL3 | 3.313631e+01 | 8.736393e-01 | 8.200174e-05 | 2.370254e-03 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for FSTL3 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_186125 | chr19 | 680274:680489:681333:681560:681650:681673 | 681333:681560 |
exon_skip_271199 | chr19 | 680751:680879:681333:681560:681650:681771 | 681333:681560 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for FSTL3 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000166139 | 681333 | 681560 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for FSTL3 |
p-ENSG00000070404_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000166139 | 2559 | 263 | 681333 | 681560 | 566 | 792 | 169 | 244 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
O95633 | 169 | 244 | 169 | 171 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
O95633 | 169 | 244 | 181 | 184 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
O95633 | 169 | 244 | 190 | 193 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
O95633 | 169 | 244 | 204 | 207 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
O95633 | 169 | 244 | 210 | 212 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
O95633 | 169 | 244 | 217 | 220 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
O95633 | 169 | 244 | 237 | 241 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
O95633 | 169 | 244 | 27 | 263 | Chain | ID=PRO_0000010115;Note=Follistatin-related protein 3 |
O95633 | 169 | 244 | 171 | 182 | Disulfide bond | . |
O95633 | 169 | 244 | 176 | 192 | Disulfide bond | . |
O95633 | 169 | 244 | 195 | 229 | Disulfide bond | . |
O95633 | 169 | 244 | 200 | 222 | Disulfide bond | . |
O95633 | 169 | 244 | 211 | 243 | Disulfide bond | . |
O95633 | 169 | 244 | 113 | 169 | Domain | Note=Kazal-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00798 |
O95633 | 169 | 244 | 170 | 193 | Domain | Note=Follistatin-like 2 |
O95633 | 169 | 244 | 189 | 245 | Domain | Note=Kazal-like 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00798 |
O95633 | 169 | 244 | 215 | 215 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18768470;Dbxref=PMID:18768470 |
O95633 | 169 | 244 | 221 | 231 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3SEK |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in FSTL3 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for FSTL3 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for FSTL3 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FSTL3 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for FSTL3 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for FSTL3 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FSTL3 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |