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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for CALCRL |
Gene summary |
Gene information | Gene symbol | CALCRL | Gene ID | 10203 |
Gene name | calcitonin receptor like receptor | |
Synonyms | CGRPR|CRLR|LMPHM8 | |
Cytomap | 2q32.1 | |
Type of gene | protein-coding | |
Description | calcitonin gene-related peptide type 1 receptorCGRP type 1 receptorcalcitonin receptor-like | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
CALCRL | GO:0001525 | angiogenesis | 20596610 |
CALCRL | GO:0006816 | calcium ion transport | 10882736 |
CALCRL | GO:0015031 | protein transport | 9620797 |
CALCRL | GO:0031623 | receptor internalization | 10882736|20074556 |
CALCRL | GO:0071329 | cellular response to sucrose stimulus | 10882736 |
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Gene structures and expression levels for CALCRL |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | UP | ENST00000447403.5 | CALCRL-205:protein_coding:CALCRL | 3.560313e+00 | 9.558551e-01 | 1.996396e-03 | 9.204746e-03 |
CB | UP | ENST00000474212.5 | CALCRL-207:lncRNA:CALCRL | 1.338329e+00 | 8.753068e-01 | 3.671948e-03 | 1.524199e-02 |
CB | UP | ENST00000410068.5 | CALCRL-203:protein_coding:CALCRL | 4.038417e+01 | 1.131373e+00 | 6.888040e-03 | 2.559924e-02 |
TC | UP | ENST00000410068.5 | CALCRL-203:protein_coding:CALCRL | 2.571347e+01 | 1.738738e+00 | 2.233561e-06 | 7.756621e-05 |
TC | UP | ENST00000474212.5 | CALCRL-207:lncRNA:CALCRL | 1.182876e+00 | 1.060188e+00 | 4.656992e-04 | 5.438930e-03 |
TC | UP | ENST00000447403.5 | CALCRL-205:protein_coding:CALCRL | 2.085007e+00 | 9.309096e-01 | 3.302855e-03 | 2.452511e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CALCRL |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_124197 | chr2 | 187387666:187387756:187431297:187431364:187448039:187448146 | 187431297:187431364 |
exon_skip_149747 | chr2 | 187387666:187387756:187431297:187431364:187436598:187436656 | 187431297:187431364 |
exon_skip_14997 | chr2 | 187431297:187431364:187436598:187436656:187448039:187448146 | 187436598:187436656 |
exon_skip_253717 | chr2 | 187385545:187385631:187387329:187387465:187387666:187387756 | 187387329:187387465 |
exon_skip_283424 | chr2 | 187385545:187385631:187387329:187387493:187387666:187387756 | 187387329:187387493 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CALCRL |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000392370 | 187387329 | 187387493 | 3UTR-3UTR |
ENST00000409998 | 187387329 | 187387493 | 3UTR-3UTR |
ENST00000409998 | 187431297 | 187431364 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000392370 | 187387329 | 187387493 | 3UTR-3UTR |
ENST00000409998 | 187387329 | 187387493 | 3UTR-3UTR |
ENST00000409998 | 187431297 | 187431364 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000392370 | 187387329 | 187387493 | 3UTR-3UTR |
ENST00000409998 | 187387329 | 187387493 | 3UTR-3UTR |
ENST00000409998 | 187431297 | 187431364 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for CALCRL |
p-ENSG00000064989_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in CALCRL |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000409998 | 187387329 | 187387493 | hsa-miR-548ac | chr2:187387474-187387481 | 8mer-1a | chr2:187387459-187387481 | 155.00 | -9.92 |
Mayo | ENST00000409998 | 187387329 | 187387493 | hsa-miR-548z | chr2:187387474-187387481 | 8mer-1a | chr2:187387459-187387481 | 155.00 | -9.92 |
Mayo | ENST00000409998 | 187387329 | 187387493 | hsa-miR-548d-3p | chr2:187387474-187387481 | 8mer-1a | chr2:187387459-187387481 | 155.00 | -9.92 |
Mayo | ENST00000409998 | 187431297 | 187431364 | hsa-miR-1323 | chr2:187431317-187431324 | 8mer-1a | chr2:187431298-187431324 | 150.00 | -18.27 |
Mayo | ENST00000409998 | 187431297 | 187431364 | hsa-miR-548o-3p | chr2:187431317-187431324 | 8mer-1a | chr2:187431298-187431324 | 150.00 | -18.27 |
Mayo | ENST00000409998 | 187387329 | 187387493 | hsa-miR-548bb-3p | chr2:187387474-187387481 | 8mer-1a | chr2:187387459-187387481 | 155.00 | -9.92 |
Mayo | ENST00000409998 | 187387329 | 187387493 | hsa-miR-548h-3p | chr2:187387474-187387481 | 8mer-1a | chr2:187387459-187387481 | 155.00 | -9.92 |
MSBB | ENST00000409998 | 187387329 | 187387493 | hsa-miR-548ac | chr2:187387474-187387481 | 8mer-1a | chr2:187387459-187387481 | 155.00 | -9.92 |
MSBB | ENST00000409998 | 187387329 | 187387493 | hsa-miR-548z | chr2:187387474-187387481 | 8mer-1a | chr2:187387459-187387481 | 155.00 | -9.92 |
MSBB | ENST00000409998 | 187387329 | 187387493 | hsa-miR-548d-3p | chr2:187387474-187387481 | 8mer-1a | chr2:187387459-187387481 | 155.00 | -9.92 |
MSBB | ENST00000409998 | 187431297 | 187431364 | hsa-miR-1323 | chr2:187431317-187431324 | 8mer-1a | chr2:187431298-187431324 | 150.00 | -18.27 |
MSBB | ENST00000409998 | 187431297 | 187431364 | hsa-miR-548o-3p | chr2:187431317-187431324 | 8mer-1a | chr2:187431298-187431324 | 150.00 | -18.27 |
MSBB | ENST00000409998 | 187387329 | 187387493 | hsa-miR-548bb-3p | chr2:187387474-187387481 | 8mer-1a | chr2:187387459-187387481 | 155.00 | -9.92 |
MSBB | ENST00000409998 | 187387329 | 187387493 | hsa-miR-548h-3p | chr2:187387474-187387481 | 8mer-1a | chr2:187387459-187387481 | 155.00 | -9.92 |
ROSMAP | ENST00000409998 | 187387329 | 187387493 | hsa-miR-548ac | chr2:187387474-187387481 | 8mer-1a | chr2:187387459-187387481 | 155.00 | -9.92 |
ROSMAP | ENST00000409998 | 187387329 | 187387493 | hsa-miR-548z | chr2:187387474-187387481 | 8mer-1a | chr2:187387459-187387481 | 155.00 | -9.92 |
ROSMAP | ENST00000409998 | 187387329 | 187387493 | hsa-miR-548d-3p | chr2:187387474-187387481 | 8mer-1a | chr2:187387459-187387481 | 155.00 | -9.92 |
ROSMAP | ENST00000409998 | 187431297 | 187431364 | hsa-miR-1323 | chr2:187431317-187431324 | 8mer-1a | chr2:187431298-187431324 | 150.00 | -18.27 |
ROSMAP | ENST00000409998 | 187431297 | 187431364 | hsa-miR-548o-3p | chr2:187431317-187431324 | 8mer-1a | chr2:187431298-187431324 | 150.00 | -18.27 |
ROSMAP | ENST00000409998 | 187387329 | 187387493 | hsa-miR-548bb-3p | chr2:187387474-187387481 | 8mer-1a | chr2:187387459-187387481 | 155.00 | -9.92 |
ROSMAP | ENST00000409998 | 187387329 | 187387493 | hsa-miR-548h-3p | chr2:187387474-187387481 | 8mer-1a | chr2:187387459-187387481 | 155.00 | -9.92 |
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SNVs in the skipped exons for CALCRL |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CALCRL |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CALCRL |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CALCRL |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
IFG | NUP42 | exon_skip_124197 | -6.384111e-01 | 2.451160e-03 |
IFG | RALYL | exon_skip_124197 | -6.421976e-01 | 2.265496e-03 |
IFG | NOVA1 | exon_skip_124197 | -4.657447e-01 | 3.848869e-02 |
TC | HNRNPDL | exon_skip_283424 | 4.213630e-01 | 3.032306e-06 |
TC | HNRNPD | exon_skip_283424 | 4.180809e-01 | 3.683153e-06 |
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RelatedDrugs for CALCRL |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Q16602 | approved|investigational | DB14039 | Erenumab | biotech | Q16602 |
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RelatedDiseases for CALCRL |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |