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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ADAM10 |
 Gene summary |
| Gene information | Gene symbol | ADAM10 | Gene ID | 102 |
| Gene name | ADAM metallopeptidase domain 10 | |
| Synonyms | AD10|AD18|CD156c|CDw156|HsT18717|MADM|RAK|kuz | |
| Cytomap | 15q21.3 | |
| Type of gene | protein-coding | |
| Description | disintegrin and metalloproteinase domain-containing protein 10a disintegrin and metalloprotease domain 10kuzbanian protein homologmammalian disintegrin-metalloprotease | |
| Modification date | 20200329 | |
| UniProtAcc | ||
| Context | - 28409746(The Role of ADAM10 in Alzheimer's Disease) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ADAM10 | GO:0006509 | membrane protein ectodomain proteolysis | 12714508|17557115|18355449|18419754|18676862|19114711 |
| ADAM10 | GO:0007162 | negative regulation of cell adhesion | 12714508 |
| ADAM10 | GO:0034612 | response to tumor necrosis factor | 11831872 |
| ADAM10 | GO:0051089 | constitutive protein ectodomain proteolysis | 12714508 |
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Gene structures and expression levels for ADAM10 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000137845
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ADAM10 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_154738 | chr15 | 58640777:58640960:58643886:58643978:58646055:58646204 | 58643886:58643978 |
| exon_skip_220800 | chr15 | 58679159:58679282:58682196:58682314:58717577:58717727 | 58682196:58682314 |
| exon_skip_261559 | chr15 | 58665097:58665197:58676143:58676293:58679124:58679282 | 58676143:58676293 |
| exon_skip_265283 | chr15 | 58665146:58665197:58679124:58679282:58682196:58682314 | 58679124:58679282 |
| exon_skip_285947 | chr15 | 58665182:58665197:58676143:58676293:58679124:58679282 | 58676143:58676293 |
| exon_skip_59119 | chr15 | 58610999:58611107:58611808:58611991:58621471:58621504 | 58611808:58611991 |
| exon_skip_83851 | chr15 | 58597202:58597641:58599598:58599724:58610297:58610517 | 58599598:58599724 |
| exon_skip_87062 | chr15 | 58610297:58610517:58610999:58611107:58611808:58611991 | 58610999:58611107 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ADAM10 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000260408 | 58599598 | 58599724 | Frame-shift |
| ENST00000260408 | 58682196 | 58682314 | Frame-shift |
| ENST00000260408 | 58643886 | 58643978 | In-frame |
| ENST00000260408 | 58679124 | 58679282 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000260408 | 58599598 | 58599724 | Frame-shift |
| ENST00000260408 | 58610999 | 58611107 | Frame-shift |
| ENST00000260408 | 58611808 | 58611991 | Frame-shift |
| ENST00000260408 | 58682196 | 58682314 | Frame-shift |
| ENST00000260408 | 58643886 | 58643978 | In-frame |
| ENST00000260408 | 58679124 | 58679282 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000260408 | 58599598 | 58599724 | Frame-shift |
| ENST00000260408 | 58610999 | 58611107 | Frame-shift |
| ENST00000260408 | 58682196 | 58682314 | Frame-shift |
| ENST00000260408 | 58643886 | 58643978 | In-frame |
| ENST00000260408 | 58679124 | 58679282 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ADAM10 |
p-ENSG00000137845_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000260408 | 11448 | 748 | 58679124 | 58679282 | 770 | 927 | 108 | 161 |
| ENST00000260408 | 11448 | 748 | 58643886 | 58643978 | 1180 | 1271 | 245 | 275 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000260408 | 11448 | 748 | 58679124 | 58679282 | 770 | 927 | 108 | 161 |
| ENST00000260408 | 11448 | 748 | 58643886 | 58643978 | 1180 | 1271 | 245 | 275 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000260408 | 11448 | 748 | 58679124 | 58679282 | 770 | 927 | 108 | 161 |
| ENST00000260408 | 11448 | 748 | 58643886 | 58643978 | 1180 | 1271 | 245 | 275 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O14672 | 108 | 161 | 19 | 319 | Alternative sequence | ID=VSP_056401;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| O14672 | 108 | 161 | 139 | 139 | Natural variant | ID=VAR_070907;Note=In RAK. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23666529;Dbxref=dbSNP:rs483352912,PMID:23666529 |
| O14672 | 108 | 161 | 20 | 213 | Propeptide | ID=PRO_0000029066;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q10741 |
| O14672 | 108 | 161 | 20 | 672 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14672 | 245 | 275 | 19 | 319 | Alternative sequence | ID=VSP_056401;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| O14672 | 245 | 275 | 269 | 277 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BE6 |
| O14672 | 245 | 275 | 214 | 748 | Chain | ID=PRO_0000029067;Note=Disintegrin and metalloproteinase domain-containing protein 10 |
| O14672 | 245 | 275 | 222 | 313 | Disulfide bond | Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:6BDZ,ECO:0000244|PDB:6BE6,ECO:0000269|PubMed:29224781;Dbxref=PMID:29224781 |
| O14672 | 245 | 275 | 220 | 456 | Domain | Note=Peptidase M12B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00276 |
| O14672 | 245 | 275 | 267 | 267 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14672 | 245 | 275 | 239 | 258 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BE6 |
| O14672 | 245 | 275 | 20 | 672 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O14672 | 108 | 161 | 19 | 319 | Alternative sequence | ID=VSP_056401;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| O14672 | 108 | 161 | 139 | 139 | Natural variant | ID=VAR_070907;Note=In RAK. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23666529;Dbxref=dbSNP:rs483352912,PMID:23666529 |
| O14672 | 108 | 161 | 20 | 213 | Propeptide | ID=PRO_0000029066;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q10741 |
| O14672 | 108 | 161 | 20 | 672 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14672 | 245 | 275 | 19 | 319 | Alternative sequence | ID=VSP_056401;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| O14672 | 245 | 275 | 269 | 277 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BE6 |
| O14672 | 245 | 275 | 214 | 748 | Chain | ID=PRO_0000029067;Note=Disintegrin and metalloproteinase domain-containing protein 10 |
| O14672 | 245 | 275 | 222 | 313 | Disulfide bond | Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:6BDZ,ECO:0000244|PDB:6BE6,ECO:0000269|PubMed:29224781;Dbxref=PMID:29224781 |
| O14672 | 245 | 275 | 220 | 456 | Domain | Note=Peptidase M12B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00276 |
| O14672 | 245 | 275 | 267 | 267 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14672 | 245 | 275 | 239 | 258 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BE6 |
| O14672 | 245 | 275 | 20 | 672 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O14672 | 108 | 161 | 19 | 319 | Alternative sequence | ID=VSP_056401;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| O14672 | 108 | 161 | 139 | 139 | Natural variant | ID=VAR_070907;Note=In RAK. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23666529;Dbxref=dbSNP:rs483352912,PMID:23666529 |
| O14672 | 108 | 161 | 20 | 213 | Propeptide | ID=PRO_0000029066;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q10741 |
| O14672 | 108 | 161 | 20 | 672 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14672 | 245 | 275 | 19 | 319 | Alternative sequence | ID=VSP_056401;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| O14672 | 245 | 275 | 269 | 277 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BE6 |
| O14672 | 245 | 275 | 214 | 748 | Chain | ID=PRO_0000029067;Note=Disintegrin and metalloproteinase domain-containing protein 10 |
| O14672 | 245 | 275 | 222 | 313 | Disulfide bond | Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:6BDZ,ECO:0000244|PDB:6BE6,ECO:0000269|PubMed:29224781;Dbxref=PMID:29224781 |
| O14672 | 245 | 275 | 220 | 456 | Domain | Note=Peptidase M12B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00276 |
| O14672 | 245 | 275 | 267 | 267 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O14672 | 245 | 275 | 239 | 258 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6BE6 |
| O14672 | 245 | 275 | 20 | 672 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in ADAM10 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for ADAM10 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ADAM10 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ADAM10 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ADAM10 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM6 | exon_skip_154738 | -5.143876e-01 | 1.418775e-11 |
| CB | RBM3 | exon_skip_154738 | 4.773658e-01 | 5.742551e-10 |
| CB | PCBP4 | exon_skip_154738 | 4.513020e-01 | 6.037263e-09 |
| CB | NUP42 | exon_skip_154738 | 4.460173e-01 | 9.500693e-09 |
| CB | DAZAP1 | exon_skip_220800 | -4.042151e-01 | 1.827929e-07 |
| CB | PCBP4 | exon_skip_220800 | 5.080963e-01 | 1.492370e-11 |
| CB | TRA2A | exon_skip_220800 | -4.614689e-01 | 1.509952e-09 |
| FL | RBM3 | exon_skip_154738 | 4.504421e-01 | 3.914665e-11 |
| HCC | RBM3 | exon_skip_154738 | 4.943710e-01 | 4.780657e-18 |
| IFG | RBM3 | exon_skip_154738 | 4.109496e-01 | 2.982528e-02 |
| IFG | IGF2BP2 | exon_skip_154738 | 5.063770e-01 | 5.967362e-03 |
| PCC | RBM3 | exon_skip_154738 | 5.360205e-01 | 5.121323e-17 |
| PG | RBM3 | exon_skip_154738 | 4.038393e-01 | 2.304862e-09 |
| STG | RBM3 | exon_skip_154738 | 4.495784e-01 | 1.112285e-05 |
| TC | RBM3 | exon_skip_154738 | 5.006783e-01 | 3.261523e-11 |
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RelatedDrugs for ADAM10 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ADAM10 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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