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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for MEF2C-AS1 |
Gene summary |
Gene information | Gene symbol | MEF2C-AS1 | Gene ID | 101929423 |
Gene name | MEF2C antisense RNA 1 | |
Synonyms | - | |
Cytomap | 5q14.3 | |
Type of gene | ncRNA | |
Description | CTC-454M9.1 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for MEF2C-AS1 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
PG | DOWN | ENST00000513704.5 | MEF2C-AS1-209:lncRNA:MEF2C | 3.281373e+00 | -8.304251e-01 | 3.791526e-03 | 3.769401e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MEF2C-AS1 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_102840 | chr5 | 88883399:88883485:88903938:88904160:88905209:88905270 | 88903938:88904160 |
exon_skip_112541 | chr5 | 88905209:88905270:88965841:88965915:89094959:89095029 | 88965841:88965915 |
exon_skip_120200 | chr5 | 89377283:89377362:89465666:89465775:89465916:89465982 | 89465666:89465775 |
exon_skip_131108 | chr5 | 88883417:88883485:88905209:88905270:89094959:89095029 | 88905209:88905270 |
exon_skip_17629 | chr5 | 89150533:89150595:89150724:89150777:89304750:89305171 | 89150724:89150777 |
exon_skip_176941 | chr5 | 88889460:88889480:88905209:88905270:88965841:88965872 | 88905209:88905270 |
exon_skip_1789 | chr5 | 88965875:88965915:89094959:89095029:89150533:89150595 | 89094959:89095029 |
exon_skip_192879 | chr5 | 88943087:88943122:88948136:88948215:88965841:88965872 | 88948136:88948215 |
exon_skip_198009 | chr5 | 88905209:88905270:88905702:88905773:88940813:88941370 | 88905702:88905773 |
exon_skip_204582 | chr5 | 89094959:89095029:89150533:89150595:89168250:89168668 | 89150533:89150595 |
exon_skip_217855 | chr5 | 88905209:88905270:89094959:89095029:89150533:89150595 | 89094959:89095029 |
exon_skip_241107 | chr5 | 88883417:88883485:88903938:88904160:88905209:88905268 | 88903938:88904160 |
exon_skip_28379 | chr5 | 88905209:88905270:88943016:88943122:88948136:88948215 | 88943016:88943122 |
exon_skip_39647 | chr5 | 88883417:88883485:88903938:88904160:88905209:88905270 | 88903938:88904160 |
exon_skip_45154 | chr5 | 88892257:88892277:88903938:88904160:88905209:88905270 | 88903938:88904160 |
exon_skip_55532 | chr5 | 88905209:88905270:88943016:88943122:88965841:88965872 | 88943016:88943122 |
exon_skip_61248 | chr5 | 88965875:88965915:89094959:89095029:89377283:89377362 | 89094959:89095029 |
exon_skip_68152 | chr5 | 88889454:88889480:88892167:88892277:88905209:88905270 | 88892167:88892277 |
exon_skip_85251 | chr5 | 88889460:88889480:88892167:88892277:88905209:88905270 | 88892167:88892277 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
exon_skip_34236 | ROSMAP_PCC | 7.875962e-01 | 6.787500e-01 | 1.088462e-01 | 3.734957e-02 |
exon_skip_34236 | MSBB_IFG | 9.361538e-01 | 8.120000e-01 | 1.241538e-01 | 4.730516e-02 |
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Open reading frame (ORF) annotation in the exon skipping event for MEF2C-AS1 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for MEF2C-AS1 |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in MEF2C-AS1 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for MEF2C-AS1 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MEF2C-AS1 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MEF2C-AS1 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for MEF2C-AS1 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
IFG | PABPN1L | exon_skip_87219 | 4.352734e-01 | 2.061148e-02 |
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RelatedDrugs for MEF2C-AS1 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MEF2C-AS1 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |