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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CDK4 |
 Gene summary |
| Gene information | Gene symbol | CDK4 | Gene ID | 1019 |
| Gene name | cyclin dependent kinase 4 | |
| Synonyms | CMM3|PSK-J3 | |
| Cytomap | 12q14.1 | |
| Type of gene | protein-coding | |
| Description | cyclin-dependent kinase 4cell division protein kinase 4 | |
| Modification date | 20200329 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CDK4 | GO:0006468 | protein phosphorylation | 8114739 |
| CDK4 | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle | 19124461 |
| CDK4 | GO:0071157 | negative regulation of cell cycle arrest | 19124461 |
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Gene structures and expression levels for CDK4 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000135446
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| TC | DOWN | ENST00000552713.5 | CDK4-213:retained_intron:CDK4 | 7.283327e+00 | -8.453760e-01 | 1.505258e-03 | 1.349027e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CDK4 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_153767 | chr12 | 57751297:57751342:57751500:57751736:57752175:57752276 | 57751500:57751736 |
| exon_skip_157117 | chr12 | 57751207:57751342:57751500:57751752:57752175:57752322 | 57751500:57751752 |
| exon_skip_157720 | chr12 | 57750934:57751090:57751207:57751736:57752175:57752276 | 57751207:57751736 |
| exon_skip_18394 | chr12 | 57750934:57751090:57751207:57751342:57751500:57751659 | 57751207:57751342 |
| exon_skip_192515 | chr12 | 57749454:57749504:57750656:57750765:57750923:57751090 | 57750656:57750765 |
| exon_skip_218897 | chr12 | 57751297:57751342:57751500:57751752:57752175:57752276 | 57751500:57751752 |
| exon_skip_2708 | chr12 | 57750679:57750765:57750923:57751090:57751500:57751659 | 57750923:57751090 |
| exon_skip_283115 | chr12 | 57751297:57751342:57751500:57751659:57752175:57752276 | 57751500:57751659 |
| exon_skip_30954 | chr12 | 57751297:57751342:57751500:57751752:57752175:57752322 | 57751500:57751752 |
| exon_skip_38711 | chr12 | 57751207:57751342:57751500:57751736:57752175:57752322 | 57751500:57751736 |
| exon_skip_62448 | chr12 | 57750934:57751090:57751207:57751342:57752175:57752276 | 57751207:57751342 |
| exon_skip_64584 | chr12 | 57751074:57751090:57751207:57751342:57751500:57751736 | 57751207:57751342 |
| exon_skip_85751 | chr12 | 57750934:57751090:57751500:57751736:57752175:57752276 | 57751500:57751736 |
| exon_skip_86902 | chr12 | 57751297:57751342:57751500:57751696:57752175:57752349 | 57751500:57751696 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CDK4 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000257904 | 57750656 | 57750765 | Frame-shift |
| ENST00000257904 | 57751207 | 57751342 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000257904 | 57751207 | 57751342 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000257904 | 57750656 | 57750765 | Frame-shift |
| ENST00000257904 | 57751207 | 57751342 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for CDK4 |
p-ENSG00000135446_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in CDK4 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CDK4 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CDK4 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CDK4 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CDK4 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for CDK4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P11802 | approved|investigational | DB09073 | Palbociclib | small molecule | P11802 |
| P11802 | approved|investigational | DB11730 | Ribociclib | small molecule | P11802 |
| P11802 | approved|investigational | DB12001 | Abemaciclib | small molecule | P11802 |
| P11802 | approved|investigational | DB12010 | Fostamatinib | small molecule | P11802 |
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RelatedDiseases for CDK4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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