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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for LPAR6 |
Gene summary |
Gene information | Gene symbol | LPAR6 | Gene ID | 10161 |
Gene name | lysophosphatidic acid receptor 6 | |
Synonyms | ARWH1|HYPT8|LAH3|P2RY5|P2Y5 | |
Cytomap | 13q14.2 | |
Type of gene | protein-coding | |
Description | lysophosphatidic acid receptor 6G-protein coupled purinergic receptor P2Y5LPA receptor 6LPA-6P2Y purinoceptor 5RB intron encoded G-protein coupled receptoroleoyl-L-alpha-lysophosphatidic acid receptorpurinergic receptor 5purinergic receptor P2Y G | |
Modification date | 20200313 | |
UniProtAcc | P43657, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for LPAR6 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for LPAR6 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_128038 | chr13 | 48415700:48415810:48416313:48416564:48417167:48417320 | 48416313:48416564 |
exon_skip_245928 | chr13 | 48422650:48422790:48423993:48424119:48426580:48426795 | 48423993:48424119 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for LPAR6 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000378434 | 48416313 | 48416564 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000378434 | 48416313 | 48416564 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for LPAR6 |
p-ENSG00000139679_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in LPAR6 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000378434 | 48416313 | 48416564 | hsa-miR-4252 | chr13:48416556-48416563 | 8mer-1a | chr13:48416544-48416563 | 147.00 | -15.97 |
Mayo | ENST00000378434 | 48416313 | 48416564 | hsa-miR-3611 | chr13:48416425-48416432 | 8mer-1a | chr13:48416425-48416445 | 152.00 | -18.16 |
Mayo | ENST00000378434 | 48416313 | 48416564 | hsa-miR-346 | chr13:48416512-48416519 | 8mer-1a | chr13:48416497-48416519 | 177.00 | -34.14 |
Mayo | ENST00000378434 | 48416313 | 48416564 | hsa-miR-4483 | chr13:48416466-48416473 | 8mer-1a | chr13:48416458-48416482 | 173.00 | -40.90 |
Mayo | ENST00000378434 | 48416313 | 48416564 | hsa-miR-1293 | chr13:48416466-48416473 | 8mer-1a | chr13:48416458-48416482 | 173.00 | -40.90 |
Mayo | ENST00000378434 | 48416313 | 48416564 | hsa-miR-5007-5p | chr13:48416402-48416409 | 8mer-1a | chr13:48416387-48416409 | 161.00 | -25.46 |
Mayo | ENST00000378434 | 48416313 | 48416564 | hsa-miR-6781-5p | chr13:48416395-48416402 | 8mer-1a | chr13:48416387-48416409 | 161.00 | -25.46 |
Mayo | ENST00000378434 | 48416313 | 48416564 | hsa-miR-636 | chr13:48416486-48416493 | 8mer-1a | chr13:48416476-48416496 | 156.00 | -16.70 |
Mayo | ENST00000378434 | 48416313 | 48416564 | hsa-miR-6806-5p | chr13:48416459-48416466 | 8mer-1a | chr13:48416458-48416482 | 173.00 | -40.90 |
Mayo | ENST00000378434 | 48416313 | 48416564 | hsa-miR-218-5p | chr13:48416487-48416494 | 8mer-1a | chr13:48416476-48416496 | 156.00 | -16.70 |
Mayo | ENST00000378434 | 48416313 | 48416564 | hsa-miR-2113 | chr13:48416489-48416496 | 8mer-1a | chr13:48416476-48416496 | 156.00 | -16.70 |
ROSMAP | ENST00000378434 | 48416313 | 48416564 | hsa-miR-4252 | chr13:48416556-48416563 | 8mer-1a | chr13:48416544-48416563 | 147.00 | -15.97 |
ROSMAP | ENST00000378434 | 48416313 | 48416564 | hsa-miR-3611 | chr13:48416425-48416432 | 8mer-1a | chr13:48416425-48416445 | 152.00 | -18.16 |
ROSMAP | ENST00000378434 | 48416313 | 48416564 | hsa-miR-346 | chr13:48416512-48416519 | 8mer-1a | chr13:48416497-48416519 | 177.00 | -34.14 |
ROSMAP | ENST00000378434 | 48416313 | 48416564 | hsa-miR-4483 | chr13:48416466-48416473 | 8mer-1a | chr13:48416458-48416482 | 173.00 | -40.90 |
ROSMAP | ENST00000378434 | 48416313 | 48416564 | hsa-miR-1293 | chr13:48416466-48416473 | 8mer-1a | chr13:48416458-48416482 | 173.00 | -40.90 |
ROSMAP | ENST00000378434 | 48416313 | 48416564 | hsa-miR-5007-5p | chr13:48416402-48416409 | 8mer-1a | chr13:48416387-48416409 | 161.00 | -25.46 |
ROSMAP | ENST00000378434 | 48416313 | 48416564 | hsa-miR-6781-5p | chr13:48416395-48416402 | 8mer-1a | chr13:48416387-48416409 | 161.00 | -25.46 |
ROSMAP | ENST00000378434 | 48416313 | 48416564 | hsa-miR-636 | chr13:48416486-48416493 | 8mer-1a | chr13:48416476-48416496 | 156.00 | -16.70 |
ROSMAP | ENST00000378434 | 48416313 | 48416564 | hsa-miR-6806-5p | chr13:48416459-48416466 | 8mer-1a | chr13:48416458-48416482 | 173.00 | -40.90 |
ROSMAP | ENST00000378434 | 48416313 | 48416564 | hsa-miR-218-5p | chr13:48416487-48416494 | 8mer-1a | chr13:48416476-48416496 | 156.00 | -16.70 |
ROSMAP | ENST00000378434 | 48416313 | 48416564 | hsa-miR-2113 | chr13:48416489-48416496 | 8mer-1a | chr13:48416476-48416496 | 156.00 | -16.70 |
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SNVs in the skipped exons for LPAR6 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for LPAR6 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for LPAR6 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for LPAR6 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for LPAR6 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LPAR6 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |