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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for AKAP9 |
 Gene summary |
| Gene information | Gene symbol | AKAP9 | Gene ID | 10142 |
| Gene name | A-kinase anchoring protein 9 | |
| Synonyms | AKAP-9|AKAP350|AKAP450|CG-NAP|HYPERION|LQT11|MU-RMS-40.16A|PPP1R45|PRKA9|YOTIAO | |
| Cytomap | 7q21.2 | |
| Type of gene | protein-coding | |
| Description | A-kinase anchor protein 9A kinase (PRKA) anchor protein (yotiao) 9A kinase (PRKA) anchor protein 9A-kinase anchor protein 350 kDaA-kinase anchor protein 450 kDaAKAP 120-like proteinAKAP9-BRAF fusion proteincentrosome- and Golgi-localized PKN-associ | |
| Modification date | 20200328 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| AKAP9 | GO:0098962 | regulation of postsynaptic neurotransmitter receptor activity | 10390370 |
| AKAP9 | GO:1903358 | regulation of Golgi organization | 27666745 |
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Gene structures and expression levels for AKAP9 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000127914
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000438114.1 | AKAP9-207:protein_coding:AKAP9 | 2.973544e+01 | 9.937754e-01 | 4.906939e-09 | 1.655912e-07 |
| CB | UP | ENST00000491695.1 | AKAP9-213:protein_coding:AKAP9 | 3.367901e+00 | 1.183216e+00 | 2.453055e-07 | 4.535635e-06 |
| CB | UP | ENST00000493453.1 | AKAP9-214:retained_intron:AKAP9 | 1.303647e+01 | 8.532495e-01 | 7.224162e-06 | 8.015179e-05 |
| TC | UP | ENST00000491695.1 | AKAP9-213:protein_coding:AKAP9 | 1.320101e+00 | 8.760142e-01 | 7.522136e-03 | 4.539816e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for AKAP9 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_134149 | chr7 | 92077696:92077875:92079079:92080152:92082522:92082662 | 92079079:92080152 |
| exon_skip_163753 | chr7 | 92076855:92077007:92077696:92077875:92079079:92080152 | 92077696:92077875 |
| exon_skip_168134 | chr7 | 92066427:92066546:92070030:92070206:92070905:92071009 | 92070030:92070206 |
| exon_skip_171616 | chr7 | 92000848:92003235:92012429:92012642:92014249:92014328 | 92012429:92012642 |
| exon_skip_176791 | chr7 | 92062274:92062486:92065231:92065463:92066427:92066546 | 92065231:92065463 |
| exon_skip_186156 | chr7 | 92102687:92102826:92105678:92105763:92107293:92107422 | 92105678:92105763 |
| exon_skip_186195 | chr7 | 92100856:92101056:92102594:92102826:92105678:92105763 | 92102594:92102826 |
| exon_skip_19942 | chr7 | 92100856:92101056:92102687:92102826:92105678:92105763 | 92102687:92102826 |
| exon_skip_201585 | chr7 | 92107293:92107422:92108494:92108633:92110122:92110467 | 92108494:92108633 |
| exon_skip_203162 | chr7 | 92070909:92071009:92076855:92077007:92077696:92077875 | 92076855:92077007 |
| exon_skip_222924 | chr7 | 92040674:92040898:92042046:92042186:92042668:92042771 | 92042046:92042186 |
| exon_skip_227676 | chr7 | 92029895:92029991:92031512:92031604:92038419:92038772 | 92031512:92031604 |
| exon_skip_236818 | chr7 | 92070905:92071009:92076855:92077007:92077696:92077875 | 92076855:92077007 |
| exon_skip_278338 | chr7 | 92040704:92040898:92042046:92042186:92042668:92042771 | 92042046:92042186 |
| exon_skip_28128 | chr7 | 91941100:91941147:91970473:91970508:91973711:91973968 | 91970473:91970508 |
| exon_skip_40927 | chr7 | 92070030:92070206:92070905:92071009:92076855:92077007 | 92070905:92071009 |
| exon_skip_432 | chr7 | 91941100:91941147:91973711:91973968:91980289:91980333 | 91973711:91973968 |
| exon_skip_55036 | chr7 | 92085495:92085686:92086228:92086416:92089385:92089529 | 92086228:92086416 |
| exon_skip_93226 | chr7 | 91980289:91980333:91992158:91992211:91992885:91993055 | 91992158:91992211 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_98121 | Mayo_CB | 3.342308e-01 | 4.538182e-01 | -1.195874e-01 | 2.434429e-06 |
| exon_skip_186156 | Mayo_CB | 7.925610e-01 | 9.128571e-01 | -1.202962e-01 | 2.245644e-06 |
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Open reading frame (ORF) annotation in the exon skipping event for AKAP9 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for AKAP9 |
p-ENSG00000127914_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in AKAP9 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for AKAP9 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for AKAP9 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for AKAP9 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for AKAP9 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TARDBP | exon_skip_227676 | -5.198911e-01 | 1.677413e-10 |
| CB | TRA2A | exon_skip_227676 | -5.550908e-01 | 4.947996e-12 |
| CB | KHSRP | exon_skip_227676 | -4.095747e-01 | 1.079479e-06 |
| CB | RBM45 | exon_skip_227676 | 6.035153e-01 | 1.872170e-14 |
| CB | CNOT4 | exon_skip_186156 | -5.040594e-01 | 1.257958e-11 |
| CB | FUBP1 | exon_skip_186156 | -5.172932e-01 | 2.920696e-12 |
| CB | HNRNPC | exon_skip_186156 | -4.507811e-01 | 2.482980e-09 |
| DLPFC | KHDRBS3 | exon_skip_93226 | -5.479692e-01 | 1.682478e-23 |
| DLPFC | KHSRP | exon_skip_93226 | -5.156208e-01 | 1.479557e-20 |
| DLPFC | HNRNPDL | exon_skip_93226 | -4.256368e-01 | 7.755402e-14 |
| DLPFC | HNRNPD | exon_skip_93226 | -4.701987e-01 | 6.440075e-17 |
| DLPFC | RALYL | exon_skip_93226 | -5.713078e-01 | 7.851225e-26 |
| DLPFC | CELF1 | exon_skip_93226 | -4.073425e-01 | 1.069276e-12 |
| DLPFC | SRSF9 | exon_skip_93226 | -4.622833e-01 | 2.451763e-16 |
| FL | KHDRBS3 | exon_skip_93226 | -4.386925e-01 | 1.755242e-10 |
| FL | RALYL | exon_skip_93226 | -4.227801e-01 | 9.071980e-10 |
| HCC | RBMS2 | exon_skip_93226 | 6.464861e-01 | 2.182194e-30 |
| HCC | TIA1 | exon_skip_93226 | 4.748184e-01 | 3.512450e-15 |
| HCC | RBM47 | exon_skip_93226 | 5.152728e-01 | 5.122095e-18 |
| HCC | RC3H1 | exon_skip_93226 | 4.715870e-01 | 5.706967e-15 |
| HCC | KHDRBS3 | exon_skip_93226 | 4.760089e-01 | 2.933513e-15 |
| HCC | FUBP3 | exon_skip_93226 | 4.020249e-01 | 6.215805e-11 |
| HCC | RALYL | exon_skip_93226 | -5.210369e-01 | 1.878751e-18 |
| HCC | HNRNPF | exon_skip_93226 | 6.107610e-01 | 1.929524e-26 |
| HCC | RBM3 | exon_skip_227676 | 4.501092e-01 | 6.343477e-14 |
| IFG | RBM47 | exon_skip_93226 | 4.364387e-01 | 2.284720e-02 |
| IFG | KHDRBS3 | exon_skip_93226 | -5.375921e-01 | 3.828778e-03 |
| IFG | RALYL | exon_skip_93226 | -5.366752e-01 | 3.901022e-03 |
| IFG | IGF2BP3 | exon_skip_227676 | -4.185222e-01 | 2.665623e-02 |
| PCC | RBMS2 | exon_skip_93226 | 5.706679e-01 | 2.245503e-17 |
| PCC | RBM47 | exon_skip_93226 | 4.983605e-01 | 5.253811e-13 |
| PCC | RALYL | exon_skip_93226 | -5.854506e-01 | 2.091444e-18 |
| PCC | HNRNPF | exon_skip_93226 | 4.519238e-01 | 1.066961e-10 |
| PG | KHDRBS3 | exon_skip_93226 | -4.970894e-01 | 2.257548e-12 |
| PG | RALYL | exon_skip_93226 | -5.590910e-01 | 7.353011e-16 |
| STG | KHDRBS3 | exon_skip_93226 | -4.224769e-01 | 5.633610e-05 |
| STG | RALYL | exon_skip_93226 | -5.051520e-01 | 8.203592e-07 |
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RelatedDrugs for AKAP9 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AKAP9 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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