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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for FRY |
 Gene summary |
| Gene information | Gene symbol | FRY | Gene ID | 10129 |
| Gene name | FRY microtubule binding protein | |
| Synonyms | 13CDNA73|214K23.2|C13orf14|CG003|bA207N4.2|bA37E23.1 | |
| Cytomap | 13q13.1 | |
| Type of gene | protein-coding | |
| Description | protein furry homologWUGSC:H_2G3A.1furry homolog | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for FRY |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000073910
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000418076.1 | FRY-203:lncRNA:FRY | 9.705823e-01 | 1.551407e+00 | 4.392278e-04 | 8.053017e-03 |
| CB | UP | ENST00000428783.1 | FRY-204:lncRNA:FRY | 9.002103e+00 | 1.175114e+00 | 1.192114e-04 | 8.593658e-04 |
| TC | UP | ENST00000641614.1 | FRY-211:retained_intron:FRY | 3.206585e+01 | 8.467839e-01 | 4.773795e-06 | 1.434508e-04 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for FRY |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_158003 | chr13 | 32124286:32124376:32124602:32124681:32124795:32124875 | 32124602:32124681 |
| exon_skip_159282 | chr13 | 32278465:32278548:32289633:32289743:32294368:32294570 | 32289633:32289743 |
| exon_skip_163709 | chr13 | 32194143:32194297:32201941:32202040:32202356:32202527 | 32201941:32202040 |
| exon_skip_16661 | chr13 | 32078834:32079033:32101963:32102016:32117334:32117470 | 32101963:32102016 |
| exon_skip_170384 | chr13 | 32178844:32179033:32179675:32179799:32182977:32183034 | 32179675:32179799 |
| exon_skip_172037 | chr13 | 32234574:32234761:32236078:32236172:32237379:32237986 | 32236078:32236172 |
| exon_skip_175765 | chr13 | 32254224:32254394:32257964:32257972:32261616:32261775 | 32257964:32257972 |
| exon_skip_187044 | chr13 | 32031774:32031865:32078834:32079033:32101963:32102016 | 32078834:32079033 |
| exon_skip_188105 | chr13 | 32136871:32136972:32147282:32147385:32147839:32147947 | 32147282:32147385 |
| exon_skip_189463 | chr13 | 32239711:32239881:32244042:32244182:32247323:32247502 | 32244042:32244182 |
| exon_skip_195286 | chr13 | 32254224:32254394:32257964:32257972:32261616:32261816 | 32257964:32257972 |
| exon_skip_209223 | chr13 | 32267243:32267359:32274842:32274991:32276464:32276562 | 32274842:32274991 |
| exon_skip_233407 | chr13 | 32147282:32147385:32147839:32147947:32149748:32149834 | 32147839:32147947 |
| exon_skip_246100 | chr13 | 32228456:32228654:32231179:32231300:32234574:32234761 | 32231179:32231300 |
| exon_skip_258256 | chr13 | 32135085:32135183:32136871:32136972:32147282:32147385 | 32136871:32136972 |
| exon_skip_262647 | chr13 | 32124795:32124875:32131672:32131840:32134904:32134996 | 32131672:32131840 |
| exon_skip_424 | chr13 | 32173367:32173549:32175546:32175632:32178177:32178436 | 32175546:32175632 |
| exon_skip_98167 | chr13 | 31846841:31846939:31941308:31941366:31946009:31946181 | 31941308:31941366 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_195286 | MSBB_PG | 6.545378e-01 | 8.197959e-01 | -1.652581e-01 | 8.473358e-03 |
| exon_skip_175765 | Mayo_TC | 4.043902e-01 | 5.095890e-01 | -1.051988e-01 | 6.234920e-03 |
| exon_skip_194286 | Mayo_TC | 5.743902e-01 | 7.025352e-01 | -1.281450e-01 | 8.091653e-05 |
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Open reading frame (ORF) annotation in the exon skipping event for FRY |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000542859 | 32078834 | 32079033 | Frame-shift |
| ENST00000542859 | 32236078 | 32236172 | Frame-shift |
| ENST00000542859 | 32101963 | 32102016 | In-frame |
| ENST00000542859 | 32175546 | 32175632 | In-frame |
| ENST00000542859 | 32244042 | 32244182 | In-frame |
| ENST00000542859 | 32274842 | 32274991 | In-frame |
| ENST00000542859 | 32289633 | 32289743 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000542859 | 32147282 | 32147385 | Frame-shift |
| ENST00000542859 | 32244042 | 32244182 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000542859 | 32124602 | 32124681 | Frame-shift |
| ENST00000542859 | 32131672 | 32131840 | Frame-shift |
| ENST00000542859 | 32147282 | 32147385 | Frame-shift |
| ENST00000542859 | 32147839 | 32147947 | Frame-shift |
| ENST00000542859 | 32179675 | 32179799 | Frame-shift |
| ENST00000542859 | 32201941 | 32202040 | Frame-shift |
| ENST00000542859 | 32231179 | 32231300 | Frame-shift |
| ENST00000542859 | 32236078 | 32236172 | Frame-shift |
| ENST00000542859 | 32136871 | 32136972 | In-frame |
| ENST00000542859 | 32175546 | 32175632 | In-frame |
| ENST00000542859 | 32244042 | 32244182 | In-frame |
| ENST00000542859 | 32274842 | 32274991 | In-frame |
| ENST00000542859 | 32289633 | 32289743 | In-frame |
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Infer the effects of exon skipping event on protein functional features for FRY |
p-ENSG00000073910_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000542859 | 13217 | 3013 | 32101963 | 32102016 | 768 | 820 | 90 | 108 |
| ENST00000542859 | 13217 | 3013 | 32175546 | 32175632 | 2832 | 2917 | 778 | 807 |
| ENST00000542859 | 13217 | 3013 | 32244042 | 32244182 | 7185 | 7324 | 2229 | 2276 |
| ENST00000542859 | 13217 | 3013 | 32274842 | 32274991 | 8634 | 8782 | 2712 | 2762 |
| ENST00000542859 | 13217 | 3013 | 32289633 | 32289743 | 8967 | 9076 | 2823 | 2860 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000542859 | 13217 | 3013 | 32244042 | 32244182 | 7185 | 7324 | 2229 | 2276 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000542859 | 13217 | 3013 | 32136871 | 32136972 | 1575 | 1675 | 359 | 393 |
| ENST00000542859 | 13217 | 3013 | 32175546 | 32175632 | 2832 | 2917 | 778 | 807 |
| ENST00000542859 | 13217 | 3013 | 32244042 | 32244182 | 7185 | 7324 | 2229 | 2276 |
| ENST00000542859 | 13217 | 3013 | 32274842 | 32274991 | 8634 | 8782 | 2712 | 2762 |
| ENST00000542859 | 13217 | 3013 | 32289633 | 32289743 | 8967 | 9076 | 2823 | 2860 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q5TBA9 | 90 | 108 | 1 | 3013 | Chain | ID=PRO_0000281674;Note=Protein furry homolog |
| Q5TBA9 | 778 | 807 | 1 | 3013 | Chain | ID=PRO_0000281674;Note=Protein furry homolog |
| Q5TBA9 | 2229 | 2276 | 1 | 3013 | Chain | ID=PRO_0000281674;Note=Protein furry homolog |
| Q5TBA9 | 2712 | 2762 | 1 | 3013 | Chain | ID=PRO_0000281674;Note=Protein furry homolog |
| Q5TBA9 | 2823 | 2860 | 1 | 3013 | Chain | ID=PRO_0000281674;Note=Protein furry homolog |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q5TBA9 | 2229 | 2276 | 1 | 3013 | Chain | ID=PRO_0000281674;Note=Protein furry homolog |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q5TBA9 | 359 | 393 | 1 | 3013 | Chain | ID=PRO_0000281674;Note=Protein furry homolog |
| Q5TBA9 | 778 | 807 | 1 | 3013 | Chain | ID=PRO_0000281674;Note=Protein furry homolog |
| Q5TBA9 | 2229 | 2276 | 1 | 3013 | Chain | ID=PRO_0000281674;Note=Protein furry homolog |
| Q5TBA9 | 2712 | 2762 | 1 | 3013 | Chain | ID=PRO_0000281674;Note=Protein furry homolog |
| Q5TBA9 | 2823 | 2860 | 1 | 3013 | Chain | ID=PRO_0000281674;Note=Protein furry homolog |
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3'-UTR located exon skipping events that lost miRNA binding sites in FRY |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for FRY |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for FRY |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| CDR | MSBB | IFG | exon_skip_195286 | -3.828831e-01 | 4.432228e-02 | chr13 | + | 32254224 | 32254394 | 32257964 | 32257972 | 32261616 | 32261816 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FRY |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for FRY |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| HCC | HNRNPF | exon_skip_195286 | -5.683695e-01 | 1.377604e-24 |
| HCC | UNK | exon_skip_194286 | -5.823144e-01 | 6.580975e-26 |
| PCC | HNRNPF | exon_skip_195286 | -5.803730e-01 | 2.651518e-20 |
| TC | NUP42 | exon_skip_194286 | 6.664296e-01 | 5.371182e-21 |
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RelatedDrugs for FRY |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FRY |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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