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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TSPAN5 |
 Gene summary |
| Gene information | Gene symbol | TSPAN5 | Gene ID | 10098 |
| Gene name | tetraspanin 5 | |
| Synonyms | NET-4|NET4|TM4SF9|TSPAN-5 | |
| Cytomap | 4q23 | |
| Type of gene | protein-coding | |
| Description | tetraspanin-5tetraspan NET-4tetraspan TM4SFtransmembrane 4 superfamily member 9transmembrane 4 superfamily, member 8 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for TSPAN5 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000168785
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000508798.5 | TSPAN5-204:nonsense_mediated_decay:TSPAN5 | 1.180338e+03 | -1.439168e+00 | 8.749752e-12 | 8.753567e-10 |
| CB | UP | ENST00000515287.5 | TSPAN5-209:protein_coding:TSPAN5 | 2.225211e+00 | 1.212553e+00 | 4.358625e-05 | 3.660368e-04 |
| CB | UP | ENST00000515440.5 | TSPAN5-210:nonsense_mediated_decay:TSPAN5 | 9.236602e-01 | 1.089036e+00 | 1.700231e-03 | 8.048695e-03 |
| CB | UP | ENST00000505184.5 | TSPAN5-202:protein_coding:TSPAN5 | 2.592161e+01 | 8.386628e-01 | 1.996592e-03 | 9.205359e-03 |
| CB | UP | ENST00000509168.5 | TSPAN5-205:lncRNA:TSPAN5 | 4.291994e+00 | 9.981314e-01 | 6.652579e-03 | 2.487903e-02 |
| TC | DOWN | ENST00000508798.5 | TSPAN5-204:nonsense_mediated_decay:TSPAN5 | 7.025288e+02 | -1.097012e+00 | 9.532836e-07 | 3.872707e-05 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TSPAN5 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_103892 | chr4 | 98486738:98486884:98507678:98507728:98657540:98657647 | 98507678:98507728 |
| exon_skip_11651 | chr4 | 98482101:98482175:98486738:98486884:98507678:98507726 | 98486738:98486884 |
| exon_skip_119618 | chr4 | 98486738:98486884:98507678:98507728:98658146:98658198 | 98507678:98507728 |
| exon_skip_13069 | chr4 | 98507678:98507728:98574457:98574582:98574744:98574905 | 98574457:98574582 |
| exon_skip_15916 | chr4 | 98482005:98482175:98484385:98484441:98486738:98486884 | 98484385:98484441 |
| exon_skip_168968 | chr4 | 98476413:98476460:98478685:98478746:98482005:98482175 | 98478685:98478746 |
| exon_skip_173903 | chr4 | 98482101:98482175:98486738:98486884:98507678:98507727 | 98486738:98486884 |
| exon_skip_20438 | chr4 | 98482101:98482175:98486738:98486884:98507678:98507728 | 98486738:98486884 |
| exon_skip_263712 | chr4 | 98476413:98476460:98478685:98478810:98482005:98482175 | 98478685:98478810 |
| exon_skip_79627 | chr4 | 98482101:98482175:98484399:98484598:98486738:98486884 | 98484399:98484598 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TSPAN5 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000305798 | 98486738 | 98486884 | In-frame |
| ENST00000305798 | 98507678 | 98507728 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000305798 | 98478685 | 98478810 | In-frame |
| ENST00000305798 | 98486738 | 98486884 | In-frame |
| ENST00000305798 | 98507678 | 98507728 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000305798 | 98478685 | 98478810 | In-frame |
| ENST00000305798 | 98486738 | 98486884 | In-frame |
| ENST00000305798 | 98507678 | 98507728 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TSPAN5 |
p-ENSG00000168785_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000305798 | 3382 | 268 | 98507678 | 98507728 | 485 | 534 | 27 | 43 |
| ENST00000305798 | 3382 | 268 | 98486738 | 98486884 | 536 | 681 | 44 | 92 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000305798 | 3382 | 268 | 98507678 | 98507728 | 485 | 534 | 27 | 43 |
| ENST00000305798 | 3382 | 268 | 98486738 | 98486884 | 536 | 681 | 44 | 92 |
| ENST00000305798 | 3382 | 268 | 98478685 | 98478810 | 854 | 978 | 150 | 191 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000305798 | 3382 | 268 | 98507678 | 98507728 | 485 | 534 | 27 | 43 |
| ENST00000305798 | 3382 | 268 | 98486738 | 98486884 | 536 | 681 | 44 | 92 |
| ENST00000305798 | 3382 | 268 | 98478685 | 98478810 | 854 | 978 | 150 | 191 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P62079 | 27 | 43 | 1 | 268 | Chain | ID=PRO_0000219243;Note=Tetraspanin-5 |
| P62079 | 27 | 43 | 39 | 61 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P62079 | 27 | 43 | 18 | 38 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P62079 | 44 | 92 | 1 | 268 | Chain | ID=PRO_0000219243;Note=Tetraspanin-5 |
| P62079 | 44 | 92 | 49 | 49 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P62079 | 44 | 92 | 91 | 94 | Sequence conflict | Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P62079 | 44 | 92 | 39 | 61 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P62079 | 44 | 92 | 83 | 92 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P62079 | 44 | 92 | 62 | 82 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P62079 | 27 | 43 | 1 | 268 | Chain | ID=PRO_0000219243;Note=Tetraspanin-5 |
| P62079 | 27 | 43 | 39 | 61 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P62079 | 27 | 43 | 18 | 38 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P62079 | 44 | 92 | 1 | 268 | Chain | ID=PRO_0000219243;Note=Tetraspanin-5 |
| P62079 | 44 | 92 | 49 | 49 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P62079 | 44 | 92 | 91 | 94 | Sequence conflict | Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P62079 | 44 | 92 | 39 | 61 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P62079 | 44 | 92 | 83 | 92 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P62079 | 44 | 92 | 62 | 82 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P62079 | 150 | 191 | 1 | 268 | Chain | ID=PRO_0000219243;Note=Tetraspanin-5 |
| P62079 | 150 | 191 | 169 | 169 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P62079 | 150 | 191 | 174 | 174 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P62079 | 150 | 191 | 114 | 232 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P62079 | 27 | 43 | 1 | 268 | Chain | ID=PRO_0000219243;Note=Tetraspanin-5 |
| P62079 | 27 | 43 | 39 | 61 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P62079 | 27 | 43 | 18 | 38 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P62079 | 44 | 92 | 1 | 268 | Chain | ID=PRO_0000219243;Note=Tetraspanin-5 |
| P62079 | 44 | 92 | 49 | 49 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P62079 | 44 | 92 | 91 | 94 | Sequence conflict | Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P62079 | 44 | 92 | 39 | 61 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P62079 | 44 | 92 | 83 | 92 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P62079 | 44 | 92 | 62 | 82 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P62079 | 150 | 191 | 1 | 268 | Chain | ID=PRO_0000219243;Note=Tetraspanin-5 |
| P62079 | 150 | 191 | 169 | 169 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P62079 | 150 | 191 | 174 | 174 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P62079 | 150 | 191 | 114 | 232 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in TSPAN5 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TSPAN5 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TSPAN5 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TSPAN5 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TSPAN5 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TIA1 | exon_skip_170907 | 4.025285e-01 | 8.209901e-06 |
| CB | HNRNPC | exon_skip_170907 | -4.702506e-01 | 1.140981e-07 |
| CB | NUP42 | exon_skip_170907 | 4.689037e-01 | 1.253883e-07 |
| IFG | TARDBP | exon_skip_20438 | 5.534427e-01 | 2.748371e-03 |
| IFG | ELAVL1 | exon_skip_20438 | 6.341725e-01 | 3.820911e-04 |
| IFG | U2AF2 | exon_skip_20438 | 5.989439e-01 | 9.636842e-04 |
| IFG | TIA1 | exon_skip_20438 | 7.509240e-01 | 6.401980e-06 |
| IFG | RBM5 | exon_skip_20438 | 6.788031e-01 | 9.926455e-05 |
| IFG | TRNAU1AP | exon_skip_20438 | 4.684645e-01 | 1.371756e-02 |
| IFG | FUBP1 | exon_skip_20438 | 6.070844e-01 | 7.856974e-04 |
| IFG | KHSRP | exon_skip_20438 | 5.679907e-01 | 1.998011e-03 |
| IFG | HNRNPA2B1 | exon_skip_20438 | 4.800837e-01 | 1.126571e-02 |
| IFG | PTBP1 | exon_skip_20438 | 5.668391e-01 | 2.050169e-03 |
| IFG | CPEB2 | exon_skip_20438 | 4.417018e-01 | 2.107606e-02 |
| IFG | RBM4 | exon_skip_20438 | 4.998937e-01 | 7.928103e-03 |
| IFG | RBM4B | exon_skip_20438 | 6.375205e-01 | 3.478729e-04 |
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RelatedDrugs for TSPAN5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TSPAN5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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