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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CDH11 |
 Gene summary |
| Gene information | Gene symbol | CDH11 | Gene ID | 1009 |
| Gene name | cadherin 11 | |
| Synonyms | CAD11|CDHOB|ESWS|OB|OSF-4 | |
| Cytomap | 16q21 | |
| Type of gene | protein-coding | |
| Description | cadherin-11cadherin 11, type 2, OB-cadherin (osteoblast) | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for CDH11 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000140937
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| TC | UP | ENST00000562325.5 | CDH11-203:protein_coding:CDH11 | 2.243270e+00 | 9.497387e-01 | 8.955949e-04 | 9.078441e-03 |
| TC | UP | ENST00000566827.5 | CDH11-212:protein_coding:CDH11 | 1.443978e+02 | 9.096072e-01 | 1.250313e-03 | 1.172379e-02 |
| TC | UP | ENST00000568340.5 | CDH11-214:lncRNA:CDH11 | 7.955903e-01 | 1.086572e+00 | 5.493032e-03 | 3.596380e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CDH11 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_123243 | chr16 | 64950767:64951018:64971579:64971696:64971931:64972064 | 64971579:64971696 |
| exon_skip_148741 | chr16 | 65004853:65005041:65053804:65053928:65121880:65121930 | 65053804:65053928 |
| exon_skip_205157 | chr16 | 64992915:64993034:64998562:64998856:65053804:65053928 | 64998562:64998856 |
| exon_skip_286975 | chr16 | 64998562:64998856:65004642:65005041:65053804:65053928 | 65004642:65005041 |
| exon_skip_35140 | chr16 | 64947547:64948099:64948609:64948787:64950767:64951018 | 64948609:64948787 |
| exon_skip_55064 | chr16 | 65004660:65005041:65053804:65053928:65121880:65122065 | 65053804:65053928 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CDH11 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000268603 | 65004642 | 65005041 | 3UTR-3CDS |
| ENST00000268603 | 65053804 | 65053928 | 3UTR-3UTR |
| ENST00000268603 | 64971579 | 64971696 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000268603 | 65004642 | 65005041 | 3UTR-3CDS |
| ENST00000268603 | 65053804 | 65053928 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000268603 | 65004642 | 65005041 | 3UTR-3CDS |
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Infer the effects of exon skipping event on protein functional features for CDH11 |
p-ENSG00000140937_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in CDH11 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| MSBB | ENST00000268603 | 65053804 | 65053928 | hsa-miR-6745 | chr16:65053848-65053855 | 8mer-1a | chr16:65053848-65053872 | 142.00 | -22.09 |
| MSBB | ENST00000268603 | 65053804 | 65053928 | hsa-miR-6755-3p | chr16:65053877-65053884 | 8mer-1a | chr16:65053863-65053884 | 154.00 | -12.74 |
| MSBB | ENST00000268603 | 65053804 | 65053928 | hsa-miR-122-5p | chr16:65053844-65053851 | 8mer-1a | chr16:65053830-65053851 | 152.00 | -18.44 |
| MSBB | ENST00000268603 | 65053804 | 65053928 | hsa-miR-1236-5p | chr16:65053864-65053871 | 8mer-1a | chr16:65053850-65053871 | 160.00 | -22.40 |
| MSBB | ENST00000268603 | 65053804 | 65053928 | hsa-miR-363-5p | chr16:65053848-65053855 | 8mer-1a | chr16:65053848-65053872 | 142.00 | -22.09 |
| ROSMAP | ENST00000268603 | 65053804 | 65053928 | hsa-miR-6745 | chr16:65053848-65053855 | 8mer-1a | chr16:65053848-65053872 | 142.00 | -22.09 |
| ROSMAP | ENST00000268603 | 65053804 | 65053928 | hsa-miR-6755-3p | chr16:65053877-65053884 | 8mer-1a | chr16:65053863-65053884 | 154.00 | -12.74 |
| ROSMAP | ENST00000268603 | 65053804 | 65053928 | hsa-miR-122-5p | chr16:65053844-65053851 | 8mer-1a | chr16:65053830-65053851 | 152.00 | -18.44 |
| ROSMAP | ENST00000268603 | 65053804 | 65053928 | hsa-miR-1236-5p | chr16:65053864-65053871 | 8mer-1a | chr16:65053850-65053871 | 160.00 | -22.40 |
| ROSMAP | ENST00000268603 | 65053804 | 65053928 | hsa-miR-363-5p | chr16:65053848-65053855 | 8mer-1a | chr16:65053848-65053872 | 142.00 | -22.09 |
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SNVs in the skipped exons for CDH11 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CDH11 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| ADstage | MSBB | IFG | exon_skip_286975 | 4.388117e-01 | 1.949096e-02 | chr16 | - | 64998562 | 64998856 | 65004642 | 65005041 | 65053804 | 65053928 |
| CDR | MSBB | IFG | exon_skip_286975 | 4.312408e-01 | 2.195236e-02 | chr16 | - | 64998562 | 64998856 | 65004642 | 65005041 | 65053804 | 65053928 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CDH11 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CDH11 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for CDH11 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDH11 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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