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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for MRLN |
Gene summary |
Gene information | Gene symbol | MRLN | Gene ID | 100507027 |
Gene name | myoregulin | |
Synonyms | LINC00948|Linc-RAM|M1|MLN|MUSER1 | |
Cytomap | 10q21.2 | |
Type of gene | protein-coding | |
Description | myoregulinLinc-RNA activator of myogenesislong intergenic non-protein coding RNA 948muscle enriched RNA 1muscle specific 1 | |
Modification date | 20200313 | |
UniProtAcc | P0DMT0, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for MRLN |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MRLN |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_234207 | chr10 | 59738472:59738562:59738998:59739095:59753354:59753396 | 59738998:59739095 |
exon_skip_287640 | chr10 | 59738472:59738562:59738998:59739119:59753354:59753396 | 59738998:59739119 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for MRLN |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000430431 | 59738998 | 59739119 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for MRLN |
p-ENSG00000227877_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in MRLN |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000430431 | 59738998 | 59739119 | hsa-miR-6878-3p | chr10:59739018-59739025 | 8mer-1a | chr10:59739004-59739028 | 157.00 | -20.74 |
Mayo | ENST00000430431 | 59738998 | 59739119 | hsa-miR-6742-3p | chr10:59739044-59739051 | 8mer-1a | chr10:59739036-59739055 | 157.00 | -23.65 |
Mayo | ENST00000430431 | 59738998 | 59739119 | hsa-miR-9851-3p | chr10:59739076-59739083 | 8mer-1a | chr10:59739068-59739090 | 167.00 | -27.79 |
Mayo | ENST00000430431 | 59738998 | 59739119 | hsa-miR-2276-5p | chr10:59739104-59739111 | 8mer-1a | chr10:59739095-59739113 | 160.00 | -32.18 |
Mayo | ENST00000430431 | 59738998 | 59739119 | hsa-miR-6813-3p | chr10:59739022-59739029 | 8mer-1a | chr10:59739008-59739029 | 156.00 | -21.56 |
Mayo | ENST00000430431 | 59738998 | 59739119 | hsa-miR-4638-5p | chr10:59739068-59739075 | 8mer-1a | chr10:59739068-59739090 | 167.00 | -27.79 |
Mayo | ENST00000430431 | 59738998 | 59739119 | hsa-miR-593-5p | chr10:59739076-59739083 | 8mer-1a | chr10:59739068-59739090 | 167.00 | -27.79 |
Mayo | ENST00000430431 | 59738998 | 59739119 | hsa-miR-4469 | chr10:59739106-59739113 | 8mer-1a | chr10:59739095-59739113 | 160.00 | -32.18 |
Mayo | ENST00000430431 | 59738998 | 59739119 | hsa-miR-504-3p | chr10:59739086-59739093 | 8mer-1a | chr10:59739072-59739093 | 162.00 | -29.86 |
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SNVs in the skipped exons for MRLN |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MRLN |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MRLN |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for MRLN |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | RBM6 | exon_skip_287640 | -4.432912e-01 | 6.093007e-09 |
CB | RBM45 | exon_skip_287640 | 6.589226e-01 | 6.551435e-21 |
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RelatedDrugs for MRLN |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MRLN |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |