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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for ERVMER34-1 |
Gene summary |
Gene information | Gene symbol | ERVMER34-1 | Gene ID | 100288413 |
Gene name | endogenous retrovirus group MER34 member 1, envelope | |
Synonyms | HEMO|envMER34 | |
Cytomap | 4q12 | |
Type of gene | protein-coding | |
Description | endogenous retroviral envelope protein HEMOHERV-MER_4q12 provirus ancestral Env polyproteinLP9056 proteinendogenous MER34 (medium-reiteration-frequency-family-34) ORFendogenous retrovirus group MER34 member 1 Env polyproteinendogenous retrovirus grou | |
Modification date | 20200313 | |
UniProtAcc | Q9H9K5, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ERVMER34-1 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ERVMER34-1 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_184758 | chr4 | 52743517:52745943:52750710:52750829:52750930:52751064 | 52750710:52750829 |
exon_skip_218596 | chr4 | 52742553:52745943:52750710:52750829:52750930:52751069 | 52750710:52750829 |
exon_skip_284807 | chr4 | 52743517:52745943:52750710:52750829:52750930:52751069 | 52750710:52750829 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ERVMER34-1 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000440542 | 52750710 | 52750829 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000440542 | 52750710 | 52750829 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000440542 | 52750710 | 52750829 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for ERVMER34-1 |
p-ENSG00000226887_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ERVMER34-1 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000440542 | 52750710 | 52750829 | hsa-miR-1291 | chr4:52750742-52750749 | 8mer-1a | chr4:52750739-52750762 | 155.00 | -19.21 |
Mayo | ENST00000440542 | 52750710 | 52750829 | hsa-miR-758-5p | chr4:52750734-52750741 | 8mer-1a | chr4:52750721-52750742 | 159.00 | -19.66 |
Mayo | ENST00000440542 | 52750710 | 52750829 | hsa-miR-6775-3p | chr4:52750742-52750749 | 8mer-1a | chr4:52750739-52750762 | 155.00 | -19.21 |
Mayo | ENST00000440542 | 52750710 | 52750829 | hsa-miR-663b | chr4:52750744-52750751 | 8mer-1a | chr4:52750739-52750762 | 155.00 | -19.21 |
Mayo | ENST00000440542 | 52750710 | 52750829 | hsa-miR-5001-3p | chr4:52750777-52750784 | 8mer-1a | chr4:52750763-52750785 | 155.00 | -25.11 |
Mayo | ENST00000440542 | 52750710 | 52750829 | hsa-miR-6830-3p | chr4:52750755-52750762 | 8mer-1a | chr4:52750739-52750762 | 155.00 | -19.21 |
Mayo | ENST00000440542 | 52750710 | 52750829 | hsa-miR-3622b-5p | chr4:52750728-52750735 | 8mer-1a | chr4:52750721-52750742 | 159.00 | -19.66 |
MSBB | ENST00000440542 | 52750710 | 52750829 | hsa-miR-1291 | chr4:52750742-52750749 | 8mer-1a | chr4:52750739-52750762 | 155.00 | -19.21 |
MSBB | ENST00000440542 | 52750710 | 52750829 | hsa-miR-758-5p | chr4:52750734-52750741 | 8mer-1a | chr4:52750721-52750742 | 159.00 | -19.66 |
MSBB | ENST00000440542 | 52750710 | 52750829 | hsa-miR-6775-3p | chr4:52750742-52750749 | 8mer-1a | chr4:52750739-52750762 | 155.00 | -19.21 |
MSBB | ENST00000440542 | 52750710 | 52750829 | hsa-miR-663b | chr4:52750744-52750751 | 8mer-1a | chr4:52750739-52750762 | 155.00 | -19.21 |
MSBB | ENST00000440542 | 52750710 | 52750829 | hsa-miR-5001-3p | chr4:52750777-52750784 | 8mer-1a | chr4:52750763-52750785 | 155.00 | -25.11 |
MSBB | ENST00000440542 | 52750710 | 52750829 | hsa-miR-6830-3p | chr4:52750755-52750762 | 8mer-1a | chr4:52750739-52750762 | 155.00 | -19.21 |
MSBB | ENST00000440542 | 52750710 | 52750829 | hsa-miR-3622b-5p | chr4:52750728-52750735 | 8mer-1a | chr4:52750721-52750742 | 159.00 | -19.66 |
ROSMAP | ENST00000440542 | 52750710 | 52750829 | hsa-miR-1291 | chr4:52750742-52750749 | 8mer-1a | chr4:52750739-52750762 | 155.00 | -19.21 |
ROSMAP | ENST00000440542 | 52750710 | 52750829 | hsa-miR-758-5p | chr4:52750734-52750741 | 8mer-1a | chr4:52750721-52750742 | 159.00 | -19.66 |
ROSMAP | ENST00000440542 | 52750710 | 52750829 | hsa-miR-6775-3p | chr4:52750742-52750749 | 8mer-1a | chr4:52750739-52750762 | 155.00 | -19.21 |
ROSMAP | ENST00000440542 | 52750710 | 52750829 | hsa-miR-663b | chr4:52750744-52750751 | 8mer-1a | chr4:52750739-52750762 | 155.00 | -19.21 |
ROSMAP | ENST00000440542 | 52750710 | 52750829 | hsa-miR-5001-3p | chr4:52750777-52750784 | 8mer-1a | chr4:52750763-52750785 | 155.00 | -25.11 |
ROSMAP | ENST00000440542 | 52750710 | 52750829 | hsa-miR-6830-3p | chr4:52750755-52750762 | 8mer-1a | chr4:52750739-52750762 | 155.00 | -19.21 |
ROSMAP | ENST00000440542 | 52750710 | 52750829 | hsa-miR-3622b-5p | chr4:52750728-52750735 | 8mer-1a | chr4:52750721-52750742 | 159.00 | -19.66 |
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SNVs in the skipped exons for ERVMER34-1 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ERVMER34-1 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ERVMER34-1 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ERVMER34-1 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ERVMER34-1 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ERVMER34-1 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |