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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for NBPF20 |
Gene summary |
Gene information | Gene symbol | NBPF20 | Gene ID | 100288142 |
Gene name | NBPF member 20 | |
Synonyms | - | |
Cytomap | 1q21.1 | |
Type of gene | protein-coding | |
Description | neuroblastoma breakpoint family member 20 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for NBPF20 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NBPF20 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_111727 | chr1 | 145402167:145402381:145403216:145403318:145405098:145405307 | 145403216:145403318 |
exon_skip_142160 | chr1 | 145393884:145393935:145394978:145395141:145399049:145399100 | 145394978:145395141 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for NBPF20 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000392971 | 145394978 | 145395141 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000392971 | 145394978 | 145395141 | 3UTR-3UTR |
ENST00000392971 | 145403216 | 145403318 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000392971 | 145394978 | 145395141 | 3UTR-3UTR |
ENST00000392971 | 145403216 | 145403318 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for NBPF20 |
p-ENSG00000162825_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in NBPF20 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000392971 | 145394978 | 145395141 | hsa-miR-6859-5p | chr1:145395009-145395016 | 8mer-1a | chr1:145394994-145395016 | 157.00 | -17.76 |
Mayo | ENST00000392971 | 145394978 | 145395141 | hsa-miR-6878-3p | chr1:145395049-145395056 | 8mer-1a | chr1:145395040-145395060 | 154.00 | -22.83 |
Mayo | ENST00000392971 | 145394978 | 145395141 | hsa-miR-5187-5p | chr1:145395091-145395098 | 8mer-1a | chr1:145395091-145395112 | 155.00 | -26.91 |
Mayo | ENST00000392971 | 145394978 | 145395141 | hsa-miR-3916 | chr1:145395009-145395016 | 8mer-1a | chr1:145394994-145395016 | 157.00 | -17.76 |
Mayo | ENST00000392971 | 145394978 | 145395141 | hsa-miR-4722-5p | chr1:145395129-145395136 | 8mer-1a | chr1:145395118-145395138 | 152.00 | -24.06 |
Mayo | ENST00000392971 | 145403216 | 145403318 | hsa-miR-4728-3p | chr1:145403280-145403287 | 8mer-1a | chr1:145403273-145403296 | 146.00 | -9.71 |
Mayo | ENST00000392971 | 145403216 | 145403318 | hsa-miR-3678-3p | chr1:145403242-145403249 | 8mer-1a | chr1:145403240-145403261 | 160.00 | -31.53 |
Mayo | ENST00000392971 | 145394978 | 145395141 | hsa-miR-10394-5p | chr1:145395131-145395138 | 8mer-1a | chr1:145395118-145395138 | 152.00 | -24.06 |
Mayo | ENST00000392971 | 145394978 | 145395141 | hsa-miR-3125 | chr1:145395009-145395016 | 8mer-1a | chr1:145394994-145395016 | 157.00 | -17.76 |
Mayo | ENST00000392971 | 145394978 | 145395141 | hsa-miR-4431 | chr1:145395076-145395083 | 8mer-1a | chr1:145395075-145395098 | 154.00 | -24.25 |
Mayo | ENST00000392971 | 145403216 | 145403318 | hsa-miR-561-5p | chr1:145403258-145403265 | 8mer-1a | chr1:145403257-145403276 | 154.00 | -18.03 |
Mayo | ENST00000392971 | 145394978 | 145395141 | hsa-miR-877-5p | chr1:145395010-145395017 | 8mer-1a | chr1:145395000-145395017 | 150.00 | -18.51 |
Mayo | ENST00000392971 | 145403216 | 145403318 | hsa-miR-7160-5p | chr1:145403278-145403285 | 8mer-1a | chr1:145403265-145403285 | 147.00 | -20.45 |
Mayo | ENST00000392971 | 145394978 | 145395141 | hsa-miR-1205 | chr1:145395131-145395138 | 8mer-1a | chr1:145395118-145395138 | 152.00 | -24.06 |
Mayo | ENST00000392971 | 145394978 | 145395141 | hsa-miR-600 | chr1:145395034-145395041 | 8mer-1a | chr1:145395022-145395043 | 161.00 | -15.13 |
Mayo | ENST00000392971 | 145394978 | 145395141 | hsa-miR-660-3p | chr1:145395062-145395069 | 8mer-1a | chr1:145395059-145395080 | 152.00 | -20.42 |
Mayo | ENST00000392971 | 145394978 | 145395141 | hsa-miR-361-3p | chr1:145395105-145395112 | 8mer-1a | chr1:145395105-145395127 | 166.00 | -28.57 |
MSBB | ENST00000392971 | 145394978 | 145395141 | hsa-miR-6859-5p | chr1:145395009-145395016 | 8mer-1a | chr1:145394994-145395016 | 157.00 | -17.76 |
MSBB | ENST00000392971 | 145394978 | 145395141 | hsa-miR-6878-3p | chr1:145395049-145395056 | 8mer-1a | chr1:145395040-145395060 | 154.00 | -22.83 |
MSBB | ENST00000392971 | 145394978 | 145395141 | hsa-miR-5187-5p | chr1:145395091-145395098 | 8mer-1a | chr1:145395091-145395112 | 155.00 | -26.91 |
MSBB | ENST00000392971 | 145394978 | 145395141 | hsa-miR-3916 | chr1:145395009-145395016 | 8mer-1a | chr1:145394994-145395016 | 157.00 | -17.76 |
MSBB | ENST00000392971 | 145394978 | 145395141 | hsa-miR-4722-5p | chr1:145395129-145395136 | 8mer-1a | chr1:145395118-145395138 | 152.00 | -24.06 |
MSBB | ENST00000392971 | 145403216 | 145403318 | hsa-miR-4728-3p | chr1:145403280-145403287 | 8mer-1a | chr1:145403273-145403296 | 146.00 | -9.71 |
MSBB | ENST00000392971 | 145403216 | 145403318 | hsa-miR-3678-3p | chr1:145403242-145403249 | 8mer-1a | chr1:145403240-145403261 | 160.00 | -31.53 |
MSBB | ENST00000392971 | 145394978 | 145395141 | hsa-miR-10394-5p | chr1:145395131-145395138 | 8mer-1a | chr1:145395118-145395138 | 152.00 | -24.06 |
MSBB | ENST00000392971 | 145394978 | 145395141 | hsa-miR-3125 | chr1:145395009-145395016 | 8mer-1a | chr1:145394994-145395016 | 157.00 | -17.76 |
MSBB | ENST00000392971 | 145394978 | 145395141 | hsa-miR-4431 | chr1:145395076-145395083 | 8mer-1a | chr1:145395075-145395098 | 154.00 | -24.25 |
MSBB | ENST00000392971 | 145403216 | 145403318 | hsa-miR-561-5p | chr1:145403258-145403265 | 8mer-1a | chr1:145403257-145403276 | 154.00 | -18.03 |
MSBB | ENST00000392971 | 145394978 | 145395141 | hsa-miR-877-5p | chr1:145395010-145395017 | 8mer-1a | chr1:145395000-145395017 | 150.00 | -18.51 |
MSBB | ENST00000392971 | 145403216 | 145403318 | hsa-miR-7160-5p | chr1:145403278-145403285 | 8mer-1a | chr1:145403265-145403285 | 147.00 | -20.45 |
MSBB | ENST00000392971 | 145394978 | 145395141 | hsa-miR-1205 | chr1:145395131-145395138 | 8mer-1a | chr1:145395118-145395138 | 152.00 | -24.06 |
MSBB | ENST00000392971 | 145394978 | 145395141 | hsa-miR-600 | chr1:145395034-145395041 | 8mer-1a | chr1:145395022-145395043 | 161.00 | -15.13 |
MSBB | ENST00000392971 | 145394978 | 145395141 | hsa-miR-660-3p | chr1:145395062-145395069 | 8mer-1a | chr1:145395059-145395080 | 152.00 | -20.42 |
MSBB | ENST00000392971 | 145394978 | 145395141 | hsa-miR-361-3p | chr1:145395105-145395112 | 8mer-1a | chr1:145395105-145395127 | 166.00 | -28.57 |
ROSMAP | ENST00000392971 | 145394978 | 145395141 | hsa-miR-6859-5p | chr1:145395009-145395016 | 8mer-1a | chr1:145394994-145395016 | 157.00 | -17.76 |
ROSMAP | ENST00000392971 | 145394978 | 145395141 | hsa-miR-6878-3p | chr1:145395049-145395056 | 8mer-1a | chr1:145395040-145395060 | 154.00 | -22.83 |
ROSMAP | ENST00000392971 | 145394978 | 145395141 | hsa-miR-5187-5p | chr1:145395091-145395098 | 8mer-1a | chr1:145395091-145395112 | 155.00 | -26.91 |
ROSMAP | ENST00000392971 | 145394978 | 145395141 | hsa-miR-3916 | chr1:145395009-145395016 | 8mer-1a | chr1:145394994-145395016 | 157.00 | -17.76 |
ROSMAP | ENST00000392971 | 145394978 | 145395141 | hsa-miR-4722-5p | chr1:145395129-145395136 | 8mer-1a | chr1:145395118-145395138 | 152.00 | -24.06 |
ROSMAP | ENST00000392971 | 145394978 | 145395141 | hsa-miR-10394-5p | chr1:145395131-145395138 | 8mer-1a | chr1:145395118-145395138 | 152.00 | -24.06 |
ROSMAP | ENST00000392971 | 145394978 | 145395141 | hsa-miR-3125 | chr1:145395009-145395016 | 8mer-1a | chr1:145394994-145395016 | 157.00 | -17.76 |
ROSMAP | ENST00000392971 | 145394978 | 145395141 | hsa-miR-4431 | chr1:145395076-145395083 | 8mer-1a | chr1:145395075-145395098 | 154.00 | -24.25 |
ROSMAP | ENST00000392971 | 145394978 | 145395141 | hsa-miR-877-5p | chr1:145395010-145395017 | 8mer-1a | chr1:145395000-145395017 | 150.00 | -18.51 |
ROSMAP | ENST00000392971 | 145394978 | 145395141 | hsa-miR-1205 | chr1:145395131-145395138 | 8mer-1a | chr1:145395118-145395138 | 152.00 | -24.06 |
ROSMAP | ENST00000392971 | 145394978 | 145395141 | hsa-miR-600 | chr1:145395034-145395041 | 8mer-1a | chr1:145395022-145395043 | 161.00 | -15.13 |
ROSMAP | ENST00000392971 | 145394978 | 145395141 | hsa-miR-660-3p | chr1:145395062-145395069 | 8mer-1a | chr1:145395059-145395080 | 152.00 | -20.42 |
ROSMAP | ENST00000392971 | 145394978 | 145395141 | hsa-miR-361-3p | chr1:145395105-145395112 | 8mer-1a | chr1:145395105-145395127 | 166.00 | -28.57 |
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SNVs in the skipped exons for NBPF20 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for NBPF20 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NBPF20 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for NBPF20 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for NBPF20 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NBPF20 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |