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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for AKT3 |
Gene summary |
Gene information | Gene symbol | AKT3 | Gene ID | 10000 |
Gene name | AKT serine/threonine kinase 3 | |
Synonyms | MPPH|MPPH2|PKB-GAMMA|PKBG|PRKBG|RAC-PK-gamma|RAC-gamma|STK-2 | |
Cytomap | 1q43-q44 | |
Type of gene | protein-coding | |
Description | RAC-gamma serine/threonine-protein kinasePKB gammaRAC-gamma serine/threonine protein kinasev-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | |
Modification date | 20200313 | |
UniProtAcc | A0A5F9ZGY0, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
AKT3 | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 28254819 |
AKT3 | GO:1905564 | positive regulation of vascular endothelial cell proliferation | 28254819 |
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Gene structures and expression levels for AKT3 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | UP | ENST00000366540.5 | AKT3-204:protein_coding:AKT3 | 6.813931e+00 | 1.310941e+00 | 1.634406e-05 | 1.599489e-04 |
CB | DOWN | ENST00000491219.6 | AKT3-207:protein_coding:AKT3 | 3.641914e+00 | -1.104313e+00 | 7.733009e-05 | 5.965571e-04 |
CB | UP | ENST00000672460.1 | AKT3-213:nonsense_mediated_decay:AKT3 | 1.777043e+01 | 8.512616e-01 | 2.253885e-04 | 1.473809e-03 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for AKT3 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_110547 | chr1 | 243563720:243563848:243572926:243573048:243613671:243613739 | 243572926:243573048 |
exon_skip_125325 | chr1 | 243512324:243512426:243545510:243545597:243552729:243552943 | 243545510:243545597 |
exon_skip_168725 | chr1 | 243695706:243695716:243843125:243843282:243850040:243850103 | 243843125:243843282 |
exon_skip_176947 | chr1 | 243637611:243637742:243645893:243646037:243664772:243664812 | 243645893:243646037 |
exon_skip_202078 | chr1 | 243572926:243573048:243613671:243613739:243615096:243615146 | 243613671:243613739 |
exon_skip_217663 | chr1 | 243552729:243552943:243563720:243563848:243572926:243573048 | 243563720:243563848 |
exon_skip_231040 | chr1 | 243695595:243695716:243843125:243843282:243850040:243850103 | 243843125:243843282 |
exon_skip_286327 | chr1 | 243499773:243499786:243504388:243505334:243512324:243512426 | 243504388:243505334 |
exon_skip_293820 | chr1 | 243545510:243545597:243552729:243552943:243563720:243563848 | 243552729:243552943 |
exon_skip_35944 | chr1 | 243695591:243695716:243843125:243843282:243850040:243850103 | 243843125:243843282 |
exon_skip_59689 | chr1 | 243645905:243646037:243664772:243664883:243695591:243695716 | 243664772:243664883 |
exon_skip_70602 | chr1 | 243664852:243664883:243683197:243683310:243695591:243695716 | 243683197:243683310 |
exon_skip_82250 | chr1 | 243664859:243664883:243683197:243683310:243695591:243695716 | 243683197:243683310 |
exon_skip_9137 | chr1 | 243664772:243664883:243683197:243683310:243695591:243695716 | 243683197:243683310 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for AKT3 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for AKT3 |
p-ENSG00000117020_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in AKT3 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for AKT3 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for AKT3 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for AKT3 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for AKT3 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for AKT3 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AKT3 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |