Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZZZ3

Summary for ZZZ3

Gene information	Gene symbol	ZZZ3
	Ensembl ID	ENSG00000036549
	Entrez ID	26009
	Gene name	zinc finger ZZ-type containing 3
	Synonyms	ATAC1\|DKFZP564I052
	Gene type	protein_coding
	UniProtAcc	Q8IYH5

Top

Dataset with differentially expressed gene: ZZZ3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.255754	0.00e+00

Top

Expression of ZZZ3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to ZZZ3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating ZZZ3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZZZ3	hsa-miR-4672	97.4835	NM_015534
ZZZ3	hsa-miR-410-3p	97.4527	NM_015534
ZZZ3	hsa-miR-4771	97.4289	NM_015534
ZZZ3	hsa-miR-323a-3p	96.8086	NM_001308237
ZZZ3	hsa-miR-377-3p	96.3124	NM_015534
ZZZ3	hsa-miR-6511a-5p	95.755	NM_001308237
ZZZ3	hsa-miR-4482-3p	95.5335	NM_015534
ZZZ3	hsa-miR-1910-3p	94.5941	NM_001308237
ZZZ3	hsa-miR-1277-5p	94.5354	NM_001308237
ZZZ3	hsa-miR-4487	94.1808	NM_001308237
ZZZ3	hsa-miR-1178-3p	93.9286	NM_015534
ZZZ3	hsa-miR-4733-3p	93.5797	NM_015534
ZZZ3	hsa-miR-3923	93.3064	NM_015534
ZZZ3	hsa-miR-6503-3p	93.2822	NM_001308237
ZZZ3	hsa-miR-6731-3p	92.8388	NM_015534
ZZZ3	hsa-miR-6768-5p	92.7455	NM_001308237
ZZZ3	hsa-miR-6784-3p	92.105	NM_015534
ZZZ3	hsa-miR-3160-3p	91.8307	NM_001308237
ZZZ3	hsa-miR-5003-5p	91.7693	NM_001308237
ZZZ3	hsa-miR-556-3p	90.9405	NM_015534
ZZZ3	hsa-miR-6862-3p	90.6697	NM_015534
ZZZ3	hsa-miR-1236-5p	90.4534	NM_001308237
ZZZ3	hsa-miR-7974	89.8584	NM_001308237
ZZZ3	hsa-miR-197-3p	89.0722	NM_001308237
ZZZ3	hsa-miR-5584-5p	88.6246	NM_001308237
ZZZ3	hsa-miR-623	88.0409	NM_015534
ZZZ3	hsa-miR-656-3p	87.7627	NM_001308237
ZZZ3	hsa-miR-3934-3p	87.7531	NM_015534
ZZZ3	hsa-miR-5582-3p	87.5208	NM_001308237
ZZZ3	hsa-miR-4496	87.128	NM_015534
ZZZ3	hsa-miR-33a-3p	86.5389	NM_015534
ZZZ3	hsa-miR-4698	86.4009	NM_001308237
ZZZ3	hsa-miR-7110-3p	86.3936	NM_015534
ZZZ3	hsa-miR-6792-5p	86.3308	NM_001308237
ZZZ3	hsa-miR-4522	86.3131	NM_015534
ZZZ3	hsa-miR-6736-3p	86.3066	NM_001308237
ZZZ3	hsa-miR-558	86.1906	NM_001308237
ZZZ3	hsa-miR-548g-3p	85.963	NM_015534
ZZZ3	hsa-miR-4719	85.9394	NM_001308237
ZZZ3	hsa-miR-520f-3p	85.7886	NM_001308237
ZZZ3	hsa-miR-548c-3p	85.7759	NM_015534
ZZZ3	hsa-miR-4530	85.6313	NM_015534
ZZZ3	hsa-miR-5003-3p	85.0244	NM_015534
ZZZ3	hsa-miR-6737-3p	84.9255	NM_001308237
ZZZ3	hsa-miR-7157-3p	84.9255	NM_001308237
ZZZ3	hsa-miR-6500-3p	84.1911	NM_015534
ZZZ3	hsa-miR-122b-3p	84.0011	NM_001308237
ZZZ3	hsa-miR-21-3p	84.0011	NM_001308237
ZZZ3	hsa-miR-4765	83.9567	NM_001308237
ZZZ3	hsa-miR-513b-5p	83.9518	NM_015534

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating ZZZ3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZZZ3	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
ZZZ3	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ZZZ3	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
ZZZ3	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
ZZZ3	transfac_pro__M04950	EGR1 (directAnnotation).
ZZZ3	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
ZZZ3	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
ZZZ3	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
ZZZ3	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ZZZ3	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
ZZZ3	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
ZZZ3	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
ZZZ3	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ZZZ3	transfac_pro__M00652	NRF1 (directAnnotation).
ZZZ3	hdpi__ETV4	ETV4 (directAnnotation).
ZZZ3	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
ZZZ3	transfac_pro__M04866	HDAC2 (directAnnotation).
ZZZ3	jaspar__MA1122.1	TFDP1 (directAnnotation).
ZZZ3	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
ZZZ3	swissregulon__hs__ELF2	ELF2 (directAnnotation).
ZZZ3	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ZZZ3	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."