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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZYG11B

Summary for ZYG11B

Gene information	Gene symbol	ZYG11B
	Ensembl ID	ENSG00000162378
	Entrez ID	79699
	Gene name	zyg-11 family member B, cell cycle regulator
	Synonyms	FLJ13456\|ZYG11
	Gene type	protein_coding
	UniProtAcc	Q9C0D3

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Dataset with differentially expressed gene: ZYG11B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.301749	1.62e-08

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Expression of ZYG11B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZYG11B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZYG11B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZYG11B	hsa-miR-4282	99.8426	NM_024646
ZYG11B	hsa-miR-3163	99.6005	NM_024646
ZYG11B	hsa-miR-4775	98.5555	NM_024646
ZYG11B	hsa-miR-4733-5p	96.5592	NM_024646
ZYG11B	hsa-miR-4328	96.1981	NM_024646
ZYG11B	hsa-miR-548an	95.7762	NM_024646
ZYG11B	hsa-miR-590-3p	95.3709	NM_024646
ZYG11B	hsa-miR-5582-3p	94.8843	NM_024646
ZYG11B	hsa-miR-141-3p	93.8877	NM_024646
ZYG11B	hsa-miR-200a-3p	93.8877	NM_024646
ZYG11B	hsa-miR-651-3p	93.1374	NM_024646
ZYG11B	hsa-miR-548c-3p	92.8501	NM_024646
ZYG11B	hsa-miR-4789-3p	92.827	NM_024646
ZYG11B	hsa-miR-3143	92.0452	NM_024646
ZYG11B	hsa-miR-429	91.9323	NM_024646
ZYG11B	hsa-miR-488-5p	91.5685	NM_024646
ZYG11B	hsa-miR-200c-3p	91.218	NM_024646
ZYG11B	hsa-miR-200b-3p	91.218	NM_024646
ZYG11B	hsa-miR-548ar-3p	90.7471	NM_024646
ZYG11B	hsa-miR-3922-3p	90.3487	NM_024646
ZYG11B	hsa-miR-4799-5p	89.4795	NM_024646
ZYG11B	hsa-miR-449a	89.2774	NM_024646
ZYG11B	hsa-miR-34a-5p	89.2774	NM_024646
ZYG11B	hsa-miR-4633-5p	89.0901	NM_024646
ZYG11B	hsa-miR-3613-3p	89.0159	NM_024646
ZYG11B	hsa-miR-561-3p	88.2518	NM_024646
ZYG11B	hsa-miR-3176	87.8937	NM_024646
ZYG11B	hsa-miR-548x-3p	87.0476	NM_024646
ZYG11B	hsa-miR-548aj-3p	87.0476	NM_024646
ZYG11B	hsa-miR-548bc	86.3419	NM_024646
ZYG11B	hsa-miR-548e-3p	86.3419	NM_024646
ZYG11B	hsa-miR-548az-3p	86.3419	NM_024646
ZYG11B	hsa-miR-548f-3p	86.3419	NM_024646
ZYG11B	hsa-miR-548a-3p	86.3419	NM_024646
ZYG11B	hsa-miR-4729	86.1272	NM_024646
ZYG11B	hsa-miR-520d-5p	86.1212	NM_024646
ZYG11B	hsa-miR-524-5p	86.1212	NM_024646
ZYG11B	hsa-miR-10395-3p	85.6912	NM_024646
ZYG11B	hsa-miR-548am-3p	85.5595	NM_024646
ZYG11B	hsa-miR-548aq-3p	85.5595	NM_024646
ZYG11B	hsa-miR-548j-3p	85.5595	NM_024646
ZYG11B	hsa-miR-548ae-3p	85.5595	NM_024646
ZYG11B	hsa-miR-548ah-3p	85.5595	NM_024646
ZYG11B	hsa-miR-302b-5p	85.4902	NM_024646
ZYG11B	hsa-miR-552-5p	85.1337	NM_024646
ZYG11B	hsa-miR-4672	85.087	NM_024646
ZYG11B	hsa-miR-4662a-5p	84.9779	NM_024646
ZYG11B	hsa-miR-449b-5p	84.7689	NM_024646
ZYG11B	hsa-miR-34c-5p	84.7689	NM_024646
ZYG11B	hsa-miR-5692a	84.7111	NM_024646

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Motifs and transcription factors (TFs) regulating ZYG11B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZYG11B	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ZYG11B	transfac_pro__M04918	EGR1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."