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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZSWIM6

Summary for ZSWIM6

Gene information	Gene symbol	ZSWIM6
	Ensembl ID	ENSG00000130449
	Entrez ID	57688
	Gene name	zinc finger SWIM-type containing 6
	Synonyms	KIAA1577
	Gene type	protein_coding
	UniProtAcc	Q9HCJ5

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Dataset with differentially expressed gene: ZSWIM6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.78647	2.35e-03
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.644801	0.00e+00

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Expression of ZSWIM6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZSWIM6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZSWIM6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZSWIM6	hsa-miR-5011-5p	99.9999	NM_020928
ZSWIM6	hsa-miR-1277-5p	99.9937	NM_020928
ZSWIM6	hsa-miR-5692b	99.9923	NM_020928
ZSWIM6	hsa-miR-5692c	99.9923	NM_020928
ZSWIM6	hsa-miR-190a-3p	99.9888	NM_020928
ZSWIM6	hsa-miR-3163	99.8576	NM_020928
ZSWIM6	hsa-miR-369-3p	99.7514	NM_020928
ZSWIM6	hsa-miR-5010-3p	98.4205	NM_020928
ZSWIM6	hsa-miR-374a-5p	98.334	NM_020928
ZSWIM6	hsa-miR-6835-3p	98.2293	NM_020928
ZSWIM6	hsa-miR-1297	97.9833	NM_020928
ZSWIM6	hsa-miR-760	97.9113	NM_020928
ZSWIM6	hsa-miR-374b-5p	97.8152	NM_020928
ZSWIM6	hsa-miR-26a-5p	97.6526	NM_020928
ZSWIM6	hsa-miR-26b-5p	97.6526	NM_020928
ZSWIM6	hsa-miR-7974	97.5479	NM_020928
ZSWIM6	hsa-miR-5692a	97.4591	NM_020928
ZSWIM6	hsa-miR-9-3p	97.1875	NM_020928
ZSWIM6	hsa-miR-4465	96.9088	NM_020928
ZSWIM6	hsa-miR-1237-3p	96.8625	NM_020928
ZSWIM6	hsa-miR-605-5p	96.3316	NM_020928
ZSWIM6	hsa-miR-4319	96.2063	NM_020928
ZSWIM6	hsa-miR-599	96.1251	NM_020928
ZSWIM6	hsa-miR-125b-5p	95.9815	NM_020928
ZSWIM6	hsa-miR-125a-5p	95.9815	NM_020928
ZSWIM6	hsa-miR-522-5p	95.9056	NM_020928
ZSWIM6	hsa-miR-519c-5p	95.9056	NM_020928
ZSWIM6	hsa-miR-518e-5p	95.9056	NM_020928
ZSWIM6	hsa-miR-520c-5p	95.9056	NM_020928
ZSWIM6	hsa-miR-526a-5p	95.9056	NM_020928
ZSWIM6	hsa-miR-523-5p	95.9056	NM_020928
ZSWIM6	hsa-miR-519b-5p	95.9056	NM_020928
ZSWIM6	hsa-miR-518f-5p	95.9056	NM_020928
ZSWIM6	hsa-miR-518d-5p	95.9056	NM_020928
ZSWIM6	hsa-miR-519a-5p	95.9056	NM_020928
ZSWIM6	hsa-miR-4789-5p	95.7965	NM_020928
ZSWIM6	hsa-miR-466	95.4619	NM_020928
ZSWIM6	hsa-miR-4775	94.8943	NM_020928
ZSWIM6	hsa-miR-410-3p	94.7755	NM_020928
ZSWIM6	hsa-miR-3148	94.5582	NM_020928
ZSWIM6	hsa-miR-26b-3p	94.2071	NM_020928
ZSWIM6	hsa-miR-101-3p	94.0124	NM_020928
ZSWIM6	hsa-miR-592	93.9103	NM_020928
ZSWIM6	hsa-miR-4728-3p	93.7062	NM_020928
ZSWIM6	hsa-miR-5579-3p	93.4424	NM_020928
ZSWIM6	hsa-miR-2681-5p	93.2102	NM_020928
ZSWIM6	hsa-miR-3925-3p	92.8505	NM_020928
ZSWIM6	hsa-miR-4789-3p	92.5706	NM_020928
ZSWIM6	hsa-miR-590-3p	92.1987	NM_020928
ZSWIM6	hsa-miR-376c-3p	92.1039	NM_020928

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Motifs and transcription factors (TFs) regulating ZSWIM6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZSWIM6	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
ZSWIM6	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
ZSWIM6	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
ZSWIM6	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
ZSWIM6	transfac_pro__M04617	ZBTB7A (directAnnotation).
ZSWIM6	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ZSWIM6	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
ZSWIM6	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ZSWIM6	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ZSWIM6	transfac_pro__M07387	ZBTB7A (directAnnotation).
ZSWIM6	transfac_pro__M07436	WT1 (directAnnotation).
ZSWIM6	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ZSWIM6	transfac_pro__M00716	ZBTB14 (directAnnotation).
ZSWIM6	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ZSWIM6	hdpi__HIP2	UBE2K (directAnnotation).
ZSWIM6	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ZSWIM6	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ZSWIM6	transfac_pro__M04893	TAF1 (directAnnotation).
ZSWIM6	transfac_pro__M03876	ZBTB33 (directAnnotation).
ZSWIM6	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ZSWIM6	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ZSWIM6	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
ZSWIM6	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ZSWIM6	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ZSWIM6	metacluster_135.11	NR2C2 (directAnnotation).
ZSWIM6	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ZSWIM6	tfdimers__MD00038	TFAP2C (directAnnotation).
ZSWIM6	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ZSWIM6	metacluster_7.13	ZFX (directAnnotation).
ZSWIM6	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ZSWIM6	cisbp__M00968	MTF2 (directAnnotation).
ZSWIM6	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ZSWIM6	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ZSWIM6	cisbp__M00341	PAX6 (directAnnotation).
ZSWIM6	metacluster_198.3	ZFP64 (directAnnotation).
ZSWIM6	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ZSWIM6	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ZSWIM6	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ZSWIM6	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ZSWIM6	cisbp__M00788	ZFY (inferredBy_Orthology).
ZSWIM6	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ZSWIM6	metacluster_175.1	ZNF283 (directAnnotation).
ZSWIM6	hdpi__ZNF304	ZNF304 (directAnnotation).
ZSWIM6	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ZSWIM6	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ZSWIM6	transfac_pro__M01199	TRIM28 (directAnnotation).
ZSWIM6	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ZSWIM6	metacluster_151.2	ZNF23 (directAnnotation).
ZSWIM6	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ZSWIM6	transfac_pro__M03806	ZBTB7C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."