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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZNF770

Summary for ZNF770

Gene information	Gene symbol	ZNF770
	Ensembl ID	ENSG00000198146
	Entrez ID	54989
	Gene name	zinc finger protein 770
	Synonyms	FLJ20582\|PRO1914
	Gene type	protein_coding
	UniProtAcc	Q6IQ21

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Dataset with differentially expressed gene: ZNF770

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.275075	1.47e-18
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.305328	4.30e-26

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Expression of ZNF770 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZNF770

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZNF770

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZNF770	hsa-miR-3613-3p	99.5576	NM_014106
ZNF770	hsa-miR-106a-3p	98.2564	NM_014106
ZNF770	hsa-miR-3671	96.5572	NM_014106
ZNF770	hsa-miR-5692a	96.3786	NM_014106
ZNF770	hsa-miR-548m	96.1084	NM_014106
ZNF770	hsa-miR-4282	95.2219	NM_014106
ZNF770	hsa-miR-551b-5p	95.1284	NM_014106
ZNF770	hsa-miR-548ag	94.9698	NM_014106
ZNF770	hsa-miR-548ai	94.9698	NM_014106
ZNF770	hsa-miR-548ba	94.9698	NM_014106
ZNF770	hsa-miR-570-5p	94.9698	NM_014106
ZNF770	hsa-miR-338-5p	93.378	NM_014106
ZNF770	hsa-miR-137-3p	91.7689	NM_014106
ZNF770	hsa-miR-142-5p	91.6474	NM_014106
ZNF770	hsa-miR-5590-3p	91.6474	NM_014106
ZNF770	hsa-miR-548c-3p	91.4949	NM_014106
ZNF770	hsa-miR-4753-3p	91.3775	NM_014106
ZNF770	hsa-miR-4438	90.8864	NM_014106
ZNF770	hsa-miR-6780a-3p	89.8937	NM_014106
ZNF770	hsa-miR-373-5p	89.8083	NM_014106
ZNF770	hsa-miR-616-5p	89.8083	NM_014106
ZNF770	hsa-miR-371b-5p	89.8083	NM_014106
ZNF770	hsa-miR-548l	89.5402	NM_014106
ZNF770	hsa-miR-1252-5p	89.3846	NM_014106
ZNF770	hsa-miR-138-1-3p	89.3246	NM_014106
ZNF770	hsa-miR-561-3p	88.9692	NM_014106
ZNF770	hsa-miR-24-1-5p	87.1742	NM_014106
ZNF770	hsa-miR-24-2-5p	87.1742	NM_014106
ZNF770	hsa-miR-4277	86.6522	NM_014106
ZNF770	hsa-miR-607	85.9495	NM_014106
ZNF770	hsa-miR-4327	85.4511	NM_014106
ZNF770	hsa-miR-183-5p	85.2683	NM_014106
ZNF770	hsa-miR-95-5p	84.6257	NM_014106
ZNF770	hsa-miR-5007-3p	83.9674	NM_014106
ZNF770	hsa-miR-4668-5p	83.8434	NM_014106
ZNF770	hsa-miR-576-5p	82.856	NM_014106
ZNF770	hsa-miR-3973	82.6803	NM_014106
ZNF770	hsa-miR-8485	82.261	NM_014106
ZNF770	hsa-miR-4496	82.1285	NM_014106
ZNF770	hsa-miR-4495	82.1219	NM_014106
ZNF770	hsa-miR-3145-3p	81.8634	NM_014106
ZNF770	hsa-miR-4517	81.0491	NM_014106
ZNF770	hsa-miR-3975	80.8553	NM_014106
ZNF770	hsa-miR-4317	80.4281	NM_014106
ZNF770	hsa-miR-200a-5p	80.3627	NM_014106
ZNF770	hsa-miR-200b-5p	80.3627	NM_014106
ZNF770	hsa-miR-8084	80.2088	NM_014106

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Motifs and transcription factors (TFs) regulating ZNF770

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZNF770	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
ZNF770	transfac_pro__M01298	MECP2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."