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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor

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Acts as a drug target< (This gene does not contain this module)

Gene: ZNF704

Summary for ZNF704

Gene informationGene symbol

ZNF704

Ensembl ID

ENSG00000164684

Entrez ID

619279

Gene namezinc finger protein 704
SynonymsFLJ16218|Gig1
Gene typeprotein_coding
UniProtAcc

NA


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Dataset with differentially expressed gene: ZNF704

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells0.2717692.27e-24

GSE115251

Kelly cell lineCell lineNeuroblastomaNeuroblastomaTargeted therapyTAE684NAMalignant cells-0.7409820.00e+00

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Expression of ZNF704 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to ZNF704

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZNF704

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
ZNF704hsa-miR-4753-3p99.9029NM_001033723
ZNF704hsa-miR-431999.6216NM_001033723
ZNF704hsa-miR-125a-5p99.2563NM_001033723
ZNF704hsa-miR-125b-5p99.2563NM_001033723
ZNF704hsa-miR-3613-3p99.2189NM_001033723
ZNF704hsa-miR-4659b-3p99.1031NM_001033723
ZNF704hsa-miR-4659a-3p99.1031NM_001033723
ZNF704hsa-miR-3065-5p98.9448NM_001033723
ZNF704hsa-miR-314898.8879NM_001033723
ZNF704hsa-miR-6885-3p98.7505NM_001033723
ZNF704hsa-miR-130b-5p98.6837NM_001033723
ZNF704hsa-miR-892c-5p98.3531NM_001033723
ZNF704hsa-miR-6783-3p98.306NM_001033723
ZNF704hsa-miR-430698.2702NM_001033723
ZNF704hsa-miR-426298.1892NM_001033723
ZNF704hsa-miR-548aj-3p98.1327NM_001033723
ZNF704hsa-miR-548x-3p98.1327NM_001033723
ZNF704hsa-miR-5003-5p98.0673NM_001033723
ZNF704hsa-miR-569698.0318NM_001033723
ZNF704hsa-miR-428298.0275NM_001033723
ZNF704hsa-miR-1213697.9145NM_001033723
ZNF704hsa-miR-548v97.8804NM_001033723
ZNF704hsa-miR-6809-3p97.8374NM_001033723
ZNF704hsa-miR-1252-5p97.741NM_001033723
ZNF704hsa-miR-4677-5p97.6818NM_001033723
ZNF704hsa-miR-520d-5p97.6758NM_001033723
ZNF704hsa-miR-524-5p97.6758NM_001033723
ZNF704hsa-miR-548c-3p97.6504NM_001033723
ZNF704hsa-miR-4446-5p97.6432NM_001033723
ZNF704hsa-miR-582-5p97.6294NM_001033723
ZNF704hsa-miR-548aq-3p97.6191NM_001033723
ZNF704hsa-miR-548j-3p97.6191NM_001033723
ZNF704hsa-miR-548ae-3p97.6191NM_001033723
ZNF704hsa-miR-548ah-3p97.6191NM_001033723
ZNF704hsa-miR-548am-3p97.6191NM_001033723
ZNF704hsa-miR-3059-5p97.4807NM_001033723
ZNF704hsa-miR-477597.2963NM_001033723
ZNF704hsa-miR-442297.0713NM_001033723
ZNF704hsa-miR-612497.0693NM_001033723
ZNF704hsa-miR-1343-3p97.0589NM_001033723
ZNF704hsa-miR-181a-5p97.0561NM_001033723
ZNF704hsa-miR-181b-5p97.0561NM_001033723
ZNF704hsa-miR-181c-5p97.0561NM_001033723
ZNF704hsa-miR-181d-5p97.0561NM_001033723
ZNF704hsa-miR-469896.6071NM_001033723
ZNF704hsa-miR-513b-5p96.4704NM_001033723
ZNF704hsa-miR-93-5p96.446NM_001033723
ZNF704hsa-miR-519d-3p96.446NM_001033723
ZNF704hsa-miR-20b-5p96.446NM_001033723
ZNF704hsa-miR-17-5p96.446NM_001033723
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Motifs and transcription factors (TFs) regulating ZNF704

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
ZNF704metacluster_55.3E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ZNF704dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1GMEB1 (directAnnotation).
ZNF704taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNNCACGTGN_CAP_reprMAX; TFAP2C (directAnnotation).
ZNF704transfac_pro__M00652NRF1 (directAnnotation).
ZNF704kznf__ZFP57_Imbeault2017_OM_MEMEZFP57 (directAnnotation).
ZNF704transfac_pro__M04918EGR1 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.
TFmotifExpressionCell typeDatasetTimepoint
ZNF704metacluster_144.3upMalignant cells

GSE175716

NA
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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."