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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZNF664

Summary for ZNF664

Gene information	Gene symbol	ZNF664
	Ensembl ID	ENSG00000179195
	Entrez ID	144348
	Gene name	zinc finger protein 664
	Synonyms	DKFZp761B128\|ZFOC1\|ZNF176
	Gene type	protein_coding
	UniProtAcc	Q8N3J9

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Dataset with differentially expressed gene: ZNF664

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.320522	4.21e-20
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.371669	0.00e+00

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Expression of ZNF664 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZNF664

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZNF664

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZNF664	hsa-miR-3202	92.9396	NM_001204298
ZNF664	hsa-miR-9-3p	92.5087	NM_152437
ZNF664	hsa-miR-8076	92.1522	NM_152437
ZNF664	hsa-miR-378j	90.3372	NM_152437
ZNF664	hsa-miR-4476	89.9684	NM_152437
ZNF664	hsa-miR-6876-5p	89.9684	NM_152437
ZNF664	hsa-miR-3978	89.7989	NM_152437
ZNF664	hsa-miR-3668	89.1417	NM_152437
ZNF664	hsa-miR-3688-3p	88.795	NM_152437
ZNF664	hsa-miR-1297	87.6755	NM_001204298
ZNF664	hsa-miR-1224-5p	87.4143	NM_152437
ZNF664	hsa-miR-3134	87.0603	NM_152437
ZNF664	hsa-miR-548p	86.8678	NM_152437
ZNF664	hsa-miR-4503	86.8382	NM_152437
ZNF664	hsa-miR-5004-5p	85.3251	NM_001204298
ZNF664	hsa-miR-6085	85.0003	NM_001204298
ZNF664	hsa-miR-6813-5p	85.0003	NM_001204298
ZNF664	hsa-miR-4668-3p	84.8115	NM_152437
ZNF664	hsa-miR-4652-5p	84.6068	NM_001204298
ZNF664	hsa-miR-6839-5p	84.5378	NM_152437
ZNF664	hsa-miR-892c-5p	84.2437	NM_152437
ZNF664	hsa-miR-6513-3p	83.9429	NM_001204298
ZNF664	hsa-miR-26b-5p	83.7408	NM_001204298
ZNF664	hsa-miR-26a-5p	83.7408	NM_001204298
ZNF664	hsa-miR-3115	83.7283	NM_152437
ZNF664	hsa-miR-1183	83.3672	NM_152437
ZNF664	hsa-miR-2355-5p	82.8245	NM_152437
ZNF664	hsa-miR-4759	82.5681	NM_152437
ZNF664	hsa-miR-3145-3p	82.3512	NM_152437
ZNF664	hsa-miR-1200	81.3206	NM_001204298

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Motifs and transcription factors (TFs) regulating ZNF664

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZNF664	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
ZNF664	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
ZNF664	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
ZNF664	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
ZNF664	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
ZNF664	metacluster_3.14	WT1; WT1 (directAnnotation).
ZNF664	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ZNF664	cisbp__M07938	E2F1 (directAnnotation).
ZNF664	transfac_pro__M01253	CNOT3 (directAnnotation).
ZNF664	transfac_pro__M04817	ZBTB33 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."