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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: ZNF638

Summary for ZNF638

Gene informationGene symbol

ZNF638

Ensembl ID

ENSG00000075292

Entrez ID

27332

Gene namezinc finger protein 638
SynonymsMGC26130|NP220|ZFML|Zfp638
Gene typeprotein_coding
UniProtAcc

NA


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Dataset with differentially expressed gene: ZNF638

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postFibroblasts-0.8744693.26e-02

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostMalignant cells0.2582830.00e+00

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells-0.3047825.41e-16

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Expression of ZNF638 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to ZNF638

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZNF638

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
ZNF638hsa-let-7c-3p94.5362NM_001014972
ZNF638hsa-miR-520d-5p91.729NM_001014972
ZNF638hsa-miR-524-5p91.729NM_001014972
ZNF638hsa-miR-6872-3p90.2919NM_014497
ZNF638hsa-miR-6895-3p88.7386NM_001014972
ZNF638hsa-miR-472988.3528NM_001014972
ZNF638hsa-miR-3682-3p84.975NM_001014972
ZNF638hsa-miR-2115-3p84.7712NM_014497
ZNF638hsa-miR-520b-5p83.2053NM_014497
ZNF638hsa-miR-519a-2-5p83.2053NM_014497
ZNF638hsa-miR-551b-5p83.0092NM_014497
ZNF638hsa-miR-71182.2813NM_001014972
ZNF638hsa-miR-290982.2499NM_014497
ZNF638hsa-miR-365482.1968NM_001014972
ZNF638hsa-miR-493-5p82.1052NM_001014972
ZNF638hsa-miR-7-2-3p80.5316NM_014497
ZNF638hsa-miR-7-1-3p80.5316NM_014497
ZNF638hsa-let-7g-3p80.4086NM_001014972
ZNF638hsa-let-7a-2-3p80.4086NM_001014972
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Motifs and transcription factors (TFs) regulating ZNF638

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
ZNF638metacluster_135.11NR2C2 (directAnnotation).
ZNF638metacluster_135.10MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ZNF638metacluster_144.3ZNF704; ZNF704 (directAnnotation).
ZNF638metacluster_7.13ZFX (directAnnotation).
ZNF638kznf__ZNF730_Imbeault2017_RP_RCADEZNF730 (directAnnotation).
ZNF638cisbp__M00968MTF2 (directAnnotation).
ZNF638metacluster_155.23BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ZNF638metacluster_160.20JUND; PRDM15 (directAnnotation).
ZNF638cisbp__M00341PAX6 (directAnnotation).
ZNF638metacluster_198.3ZFP64 (directAnnotation).
ZNF638metacluster_141.5NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ZNF638metacluster_151.1KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ZNF638jaspar__MA0185.1DEAF1 (inferredBy_Orthology).
ZNF638metacluster_61.1DEAF1; DEAF1 (directAnnotation).
ZNF638cisbp__M00788ZFY (inferredBy_Orthology).
ZNF638kznf__ZNF213_Schmitges2016_RCADEZNF213 (directAnnotation).
ZNF638metacluster_175.1ZNF283 (directAnnotation).
ZNF638hdpi__ZNF304ZNF304 (directAnnotation).
ZNF638transfac_pro__M02844BCL6B (inferredBy_Orthology).
ZNF638metacluster_125.2TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ZNF638metacluster_133.1ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ZNF638transfac_pro__M01199TRIM28 (directAnnotation).
ZNF638kznf__ZNF682_Isakova2017_SMiLE-seqZNF682 (directAnnotation).
ZNF638metacluster_151.2ZNF23 (directAnnotation).
ZNF638transfac_public__M00189TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ZNF638transfac_pro__M01219SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ZNF638transfac_pro__M03806ZBTB7C (directAnnotation).
ZNF638transfac_pro__M00915TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ZNF638metacluster_191.2ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
ZNF638metacluster_191.3EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
ZNF638taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAPETV4; HOXB2 (directAnnotation).
ZNF638metacluster_166.4BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
ZNF638taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAPELK1; EOMES (directAnnotation).
ZNF638taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_reprELK1; TBX21 (directAnnotation).
ZNF638metacluster_34.3EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
ZNF638taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_reprELF1; MEIS1 (directAnnotation).
ZNF638cisbp__M08198ELF1 (directAnnotation).
ZNF638metacluster_174.3MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
ZNF638metacluster_174.2CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
ZNF638metacluster_55.5ZNF541 (directAnnotation).
ZNF638transfac_pro__M04950EGR1 (directAnnotation).
ZNF638taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAPELK3; FOXO1 (directAnnotation).
ZNF638taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAPERG; TEAD4 (directAnnotation).
ZNF638transfac_pro__M06032ZNF727 (directAnnotation).
ZNF638taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAPETV1; HOXB2 (directAnnotation).
ZNF638transfac_pro__M01973PLAG1 (directAnnotation).
ZNF638metacluster_79.30ZNF341; ZNF589 (directAnnotation).
ZNF638transfac_pro__M01088DEAF1 (inferredBy_Orthology).
ZNF638metacluster_30.3ZNF331; ZNF331 (directAnnotation).
ZNF638swissregulon__hs__ZBTB14ZBTB14 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."