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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZNF585B

Summary for ZNF585B

Gene information	Gene symbol	ZNF585B
	Ensembl ID	ENSG00000245680
	Entrez ID	92285
	Gene name	zinc finger protein 585B
	Synonyms	FLJ14928\|SZFP41\|Zfp27
	Gene type	protein_coding
	UniProtAcc	Q52M93

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Dataset with differentially expressed gene: ZNF585B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-2.25981	7.61e-03

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Expression of ZNF585B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZNF585B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZNF585B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZNF585B	hsa-miR-10522-5p	93.5967	NM_152279
ZNF585B	hsa-miR-12123	92.908	NM_152279
ZNF585B	hsa-miR-1253	90.1806	NM_152279
ZNF585B	hsa-miR-5007-3p	90.1367	NM_152279
ZNF585B	hsa-miR-6828-5p	90.1227	NM_152279
ZNF585B	hsa-miR-6770-5p	88.4877	NM_152279
ZNF585B	hsa-miR-570-5p	88.3601	NM_152279
ZNF585B	hsa-miR-548ba	88.3601	NM_152279
ZNF585B	hsa-miR-548ag	88.3601	NM_152279
ZNF585B	hsa-miR-548ai	88.3601	NM_152279
ZNF585B	hsa-miR-4283	85.5214	NM_152279
ZNF585B	hsa-miR-1237-3p	84.5317	NM_152279
ZNF585B	hsa-miR-6079	83.7588	NM_152279
ZNF585B	hsa-miR-1252-5p	83.6641	NM_152279
ZNF585B	hsa-miR-7160-5p	83.5174	NM_152279
ZNF585B	hsa-miR-3179	82.2662	NM_152279
ZNF585B	hsa-miR-125b-2-3p	81.7826	NM_152279
ZNF585B	hsa-miR-4476	81.6465	NM_152279
ZNF585B	hsa-miR-6876-5p	81.6465	NM_152279
ZNF585B	hsa-miR-6857-5p	81.1382	NM_152279
ZNF585B	hsa-miR-4482-3p	80.7152	NM_152279
ZNF585B	hsa-miR-1261	80.2647	NM_152279

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Motifs and transcription factors (TFs) regulating ZNF585B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."