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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZNF569

Summary for ZNF569

Gene information	Gene symbol	ZNF569
	Ensembl ID	ENSG00000196437
	Entrez ID	148266
	Gene name	zinc finger protein 569
	Synonyms	FLJ32053\|ZAP1\|Zfp74
	Gene type	protein_coding
	UniProtAcc	Q5MCW4

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Dataset with differentially expressed gene: ZNF569

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.278695	5.81e-23

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Expression of ZNF569 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZNF569

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZNF569

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZNF569	hsa-miR-3692-3p	96.3795	NM_152484
ZNF569	hsa-miR-1290	93.0525	NM_152484
ZNF569	hsa-miR-10399-5p	92.5129	NM_152484
ZNF569	hsa-miR-6504-3p	92.5129	NM_152484
ZNF569	hsa-miR-4282	92.3308	NM_152484
ZNF569	hsa-miR-578	91.655	NM_152484
ZNF569	hsa-miR-643	91.4382	NM_152484
ZNF569	hsa-let-7b-3p	89.69	NM_152484
ZNF569	hsa-miR-98-3p	89.69	NM_152484
ZNF569	hsa-let-7a-3p	89.69	NM_152484
ZNF569	hsa-let-7f-1-3p	89.69	NM_152484
ZNF569	hsa-miR-6731-3p	89.5745	NM_152484
ZNF569	hsa-miR-6833-3p	89.0523	NM_152484
ZNF569	hsa-miR-130a-5p	88.638	NM_152484
ZNF569	hsa-miR-6794-3p	88.1511	NM_152484
ZNF569	hsa-miR-16-2-3p	87.4761	NM_152484
ZNF569	hsa-miR-195-3p	87.4761	NM_152484
ZNF569	hsa-miR-548ar-3p	87.2754	NM_152484
ZNF569	hsa-miR-887-5p	86.7909	NM_152484
ZNF569	hsa-miR-3942-3p	85.2927	NM_152484
ZNF569	hsa-miR-4768-5p	85.1767	NM_152484
ZNF569	hsa-miR-8085	84.5662	NM_152484
ZNF569	hsa-miR-6731-5p	84.5662	NM_152484
ZNF569	hsa-miR-548bc	83.2005	NM_152484
ZNF569	hsa-miR-548az-3p	83.2005	NM_152484
ZNF569	hsa-miR-548f-3p	83.2005	NM_152484
ZNF569	hsa-miR-548e-3p	83.2005	NM_152484
ZNF569	hsa-miR-548a-3p	83.2005	NM_152484
ZNF569	hsa-miR-8075	82.0361	NM_152484
ZNF569	hsa-miR-4666a-5p	81.5376	NM_152484
ZNF569	hsa-miR-514a-5p	81.0138	NM_152484
ZNF569	hsa-miR-4742-3p	80.1465	NM_152484
ZNF569	hsa-miR-6831-5p	80.062	NM_152484

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Motifs and transcription factors (TFs) regulating ZNF569

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."