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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZNF518B

Summary for ZNF518B

Gene information	Gene symbol	ZNF518B
	Ensembl ID	ENSG00000178163
	Entrez ID	85460
	Gene name	zinc finger protein 518B
	Synonyms	KIAA1729
	Gene type	protein_coding
	UniProtAcc	Q9C0D4

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Dataset with differentially expressed gene: ZNF518B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.340349	0.00e+00

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Expression of ZNF518B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZNF518B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZNF518B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZNF518B	hsa-miR-4659b-3p	96.7824	NM_053042
ZNF518B	hsa-miR-4659a-3p	96.7824	NM_053042
ZNF518B	hsa-miR-548p	96.6137	NM_053042
ZNF518B	hsa-miR-3163	94.2659	NM_053042
ZNF518B	hsa-miR-4789-3p	93.0328	NM_053042
ZNF518B	hsa-miR-466	93.0148	NM_053042
ZNF518B	hsa-miR-6828-3p	92.5597	NM_053042
ZNF518B	hsa-miR-3137	92.0973	NM_053042
ZNF518B	hsa-miR-410-3p	90.6056	NM_053042
ZNF518B	hsa-miR-6785-5p	89.9639	NM_053042
ZNF518B	hsa-miR-4728-5p	89.9639	NM_053042
ZNF518B	hsa-miR-6883-5p	89.9067	NM_053042
ZNF518B	hsa-miR-149-3p	89.9067	NM_053042
ZNF518B	hsa-miR-4744	89.4659	NM_053042
ZNF518B	hsa-miR-548e-5p	89.2732	NM_053042
ZNF518B	hsa-miR-5011-5p	88.9142	NM_053042
ZNF518B	hsa-miR-767-3p	88.5915	NM_053042
ZNF518B	hsa-miR-4710	87.9088	NM_053042
ZNF518B	hsa-miR-570-3p	86.7103	NM_053042
ZNF518B	hsa-miR-6851-3p	86.1603	NM_053042
ZNF518B	hsa-miR-1179	85.6559	NM_053042
ZNF518B	hsa-miR-498-3p	85.3403	NM_053042
ZNF518B	hsa-miR-4282	85.2318	NM_053042
ZNF518B	hsa-miR-510-5p	84.51	NM_053042
ZNF518B	hsa-miR-4528	83.757	NM_053042
ZNF518B	hsa-let-7b-3p	82.5256	NM_053042
ZNF518B	hsa-miR-98-3p	82.5256	NM_053042
ZNF518B	hsa-let-7a-3p	82.5256	NM_053042
ZNF518B	hsa-let-7f-1-3p	82.5256	NM_053042
ZNF518B	hsa-miR-1250-3p	82.5081	NM_053042
ZNF518B	hsa-miR-513a-3p	82.4542	NM_053042
ZNF518B	hsa-miR-513c-3p	82.4542	NM_053042
ZNF518B	hsa-miR-5009-3p	80.6153	NM_053042

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Motifs and transcription factors (TFs) regulating ZNF518B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZNF518B	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
ZNF518B	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
ZNF518B	transfac_pro__M02089	E2F3 (directAnnotation).
ZNF518B	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ZNF518B	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
ZNF518B	transfac_pro__M04817	ZBTB33 (directAnnotation).
ZNF518B	metacluster_143.13	ZBTB7A (directAnnotation).
ZNF518B	tfdimers__MD00483	ZBTB14 (directAnnotation).
ZNF518B	cisbp__M07938	E2F1 (directAnnotation).
ZNF518B	cisbp__M00968	MTF2 (directAnnotation).
ZNF518B	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
ZNF518B	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ZNF518B	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ZNF518B	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
ZNF518B	jaspar__MA1122.1	TFDP1 (directAnnotation).
ZNF518B	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."