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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZNF486

Summary for ZNF486

Gene information	Gene symbol	ZNF486
	Ensembl ID	ENSG00000256229
	Entrez ID	90649
	Gene name	zinc finger protein 486
	Synonyms	KRBO2\|MGC2396
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ZNF486

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.37262	5.57e-06

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Expression of ZNF486 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZNF486

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZNF486

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZNF486	hsa-miR-371b-5p	97.7434	NM_052852
ZNF486	hsa-miR-616-5p	97.7434	NM_052852
ZNF486	hsa-miR-373-5p	97.7434	NM_052852
ZNF486	hsa-miR-6754-3p	97.0234	NM_052852
ZNF486	hsa-miR-412-3p	96.6244	NM_052852
ZNF486	hsa-miR-3613-3p	96.4673	NM_052852
ZNF486	hsa-miR-7151-3p	94.497	NM_052852
ZNF486	hsa-miR-12122	87.0877	NM_052852
ZNF486	hsa-miR-559	85.6413	NM_052852
ZNF486	hsa-miR-4789-5p	83.0779	NM_052852
ZNF486	hsa-miR-6507-5p	83.0668	NM_052852
ZNF486	hsa-miR-511-3p	82.8128	NM_052852
ZNF486	hsa-miR-6800-3p	82.7221	NM_052852
ZNF486	hsa-miR-548bb-5p	81.7694	NM_052852
ZNF486	hsa-miR-548as-5p	81.7694	NM_052852
ZNF486	hsa-miR-548y	81.7694	NM_052852
ZNF486	hsa-miR-548o-5p	81.7694	NM_052852
ZNF486	hsa-miR-548j-5p	81.7694	NM_052852
ZNF486	hsa-miR-548w	81.7694	NM_052852
ZNF486	hsa-miR-548am-5p	81.7694	NM_052852
ZNF486	hsa-miR-548b-5p	81.7694	NM_052852
ZNF486	hsa-miR-548i	81.7694	NM_052852
ZNF486	hsa-miR-548d-5p	81.7694	NM_052852
ZNF486	hsa-miR-548a-5p	81.7694	NM_052852
ZNF486	hsa-miR-548c-5p	81.7694	NM_052852
ZNF486	hsa-miR-548ak	81.7694	NM_052852
ZNF486	hsa-miR-548ab	81.7694	NM_052852
ZNF486	hsa-miR-548ay-5p	81.7694	NM_052852
ZNF486	hsa-miR-548ar-5p	81.7694	NM_052852
ZNF486	hsa-miR-548h-5p	81.7694	NM_052852
ZNF486	hsa-miR-548ad-5p	81.7694	NM_052852
ZNF486	hsa-miR-548ae-5p	81.7694	NM_052852
ZNF486	hsa-miR-548ap-5p	81.7694	NM_052852
ZNF486	hsa-miR-548au-5p	81.7694	NM_052852
ZNF486	hsa-miR-548aq-5p	81.7694	NM_052852
ZNF486	hsa-miR-183-3p	81.0601	NM_052852
ZNF486	hsa-miR-548av-5p	80.3288	NM_052852
ZNF486	hsa-miR-8054	80.3288	NM_052852
ZNF486	hsa-miR-548k	80.3288	NM_052852

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Motifs and transcription factors (TFs) regulating ZNF486

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."