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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZNF480

Summary for ZNF480

Gene information	Gene symbol	ZNF480
	Ensembl ID	ENSG00000198464
	Entrez ID	147657
	Gene name	zinc finger protein 480
	Synonyms	MGC32104
	Gene type	protein_coding
	UniProtAcc	Q8WV37

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Dataset with differentially expressed gene: ZNF480

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.360055	0.00e+00

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Expression of ZNF480 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZNF480

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZNF480

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZNF480	hsa-miR-561-5p	95.2483	NM_001297625
ZNF480	hsa-miR-5571-5p	93.5232	NM_001297625
ZNF480	hsa-miR-329-5p	92.5011	NM_001297625
ZNF480	hsa-miR-6516-5p	92.0293	NM_001297625
ZNF480	hsa-miR-335-3p	91.4359	NM_001297625
ZNF480	hsa-miR-6885-3p	89.5749	NM_001297625
ZNF480	hsa-miR-4474-3p	89.2774	NM_001297625
ZNF480	hsa-miR-5088-3p	86.7542	NM_001297625
ZNF480	hsa-miR-511-5p	85.5039	NM_001297625
ZNF480	hsa-miR-4716-5p	84.7645	NM_001297625
ZNF480	hsa-miR-511-3p	83.8994	NM_001297625
ZNF480	hsa-miR-6505-5p	83.4529	NM_001297625
ZNF480	hsa-miR-3925-3p	83.2111	NM_001297625
ZNF480	hsa-miR-6830-5p	83.1485	NM_001297625
ZNF480	hsa-miR-6499-3p	83.135	NM_001297625
ZNF480	hsa-miR-34a-3p	83.0472	NM_001297625
ZNF480	hsa-miR-7152-3p	82.5874	NM_001297625
ZNF480	hsa-miR-339-5p	82.5863	NM_001297625
ZNF480	hsa-miR-4762-3p	81.6819	NM_001297625

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Motifs and transcription factors (TFs) regulating ZNF480

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZNF480	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
ZNF480	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
ZNF480	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
ZNF480	cisbp__M08198	ELF1 (directAnnotation).
ZNF480	hdpi__ETV4	ETV4 (directAnnotation).
ZNF480	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
ZNF480	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."