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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZNF451

Summary for ZNF451

Gene information	Gene symbol	ZNF451
	Ensembl ID	ENSG00000112200
	Entrez ID	26036
	Gene name	zinc finger protein 451
	Synonyms	COASTER\|dJ417I1.1\|KIAA0576\|KIAA1702\|ZATT
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ZNF451

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.417475	7.07e-39
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.306415	1.90e-15
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.255955	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.746088	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.265919	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.274541	9.14e-33
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.290068	1.10e-36

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Expression of ZNF451 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZNF451

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZNF451

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZNF451	hsa-miR-4495	97.4053	NM_001257273
ZNF451	hsa-miR-1200	96.9052	NM_001257273
ZNF451	hsa-miR-3613-3p	95.8078	NM_001257273
ZNF451	hsa-miR-4293	95.5936	NM_001257273
ZNF451	hsa-miR-373-5p	93.3161	NM_001257273
ZNF451	hsa-miR-371b-5p	93.3161	NM_001257273
ZNF451	hsa-miR-616-5p	93.3161	NM_001257273
ZNF451	hsa-miR-4282	92.3923	NM_001031623
ZNF451	hsa-miR-3922-5p	91.8495	NM_001031623
ZNF451	hsa-miR-3133	91.0297	NM_001031623
ZNF451	hsa-miR-10522-5p	90.5275	NM_001031623
ZNF451	hsa-miR-5190	89.9771	NM_001031623
ZNF451	hsa-miR-6882-5p	88.6392	NM_001031623
ZNF451	hsa-miR-3646	88.5476	NM_001257273
ZNF451	hsa-miR-651-3p	87.8691	NM_001257273
ZNF451	hsa-miR-4719	87.8474	NM_001257273
ZNF451	hsa-miR-101-3p	87.7439	NM_001031623
ZNF451	hsa-miR-93-3p	87.6413	NM_001257273
ZNF451	hsa-miR-4777-3p	87.2409	NM_001257273
ZNF451	hsa-miR-4698	86.87	NM_001257273
ZNF451	hsa-miR-3662	86.844	NM_001257273
ZNF451	hsa-miR-4635	86.4795	NM_001031623
ZNF451	hsa-miR-378a-5p	86.3971	NM_001257273
ZNF451	hsa-miR-4717-3p	86.1326	NM_001257273
ZNF451	hsa-miR-3973	86.0727	NM_001257273
ZNF451	hsa-miR-3671	86.0189	NM_001257273
ZNF451	hsa-miR-7161-5p	85.5906	NM_001031623
ZNF451	hsa-miR-548u	85.5906	NM_001031623
ZNF451	hsa-miR-4529-5p	85.3239	NM_001257273
ZNF451	hsa-miR-875-3p	85.2655	NM_001257273
ZNF451	hsa-miR-212-3p	85.147	NM_001031623
ZNF451	hsa-miR-132-3p	85.147	NM_001031623
ZNF451	hsa-miR-1283	84.9089	NM_001257273
ZNF451	hsa-miR-4799-5p	84.851	NM_001031623
ZNF451	hsa-miR-12120	84.8357	NM_001257273
ZNF451	hsa-miR-4307	84.6648	NM_001031623
ZNF451	hsa-miR-5692a	84.6578	NM_001257273
ZNF451	hsa-miR-3143	84.1958	NM_001257273
ZNF451	hsa-let-7c-3p	84.1557	NM_001257273
ZNF451	hsa-miR-8063	83.9222	NM_001257273
ZNF451	hsa-miR-944	83.8232	NM_001031623
ZNF451	hsa-miR-1228-3p	83.2233	NM_001031623
ZNF451	hsa-miR-182-5p	83.073	NM_001257273
ZNF451	hsa-miR-203a-3p	82.9916	NM_001257273
ZNF451	hsa-miR-600	82.9211	NM_001257273
ZNF451	hsa-miR-548c-3p	82.8044	NM_001257273
ZNF451	hsa-miR-3148	82.74	NM_001257273
ZNF451	hsa-miR-4671-3p	82.6583	NM_001257273
ZNF451	hsa-miR-4436b-5p	82.4256	NM_001257273
ZNF451	hsa-miR-500a-5p	82.379	NM_001031623

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Motifs and transcription factors (TFs) regulating ZNF451

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZNF451	metacluster_7.13	ZFX (directAnnotation).
ZNF451	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
ZNF451	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ZNF451	metacluster_151.2	ZNF23 (directAnnotation).
ZNF451	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ZNF451	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ZNF451	hdpi__ETV4	ETV4 (directAnnotation).
ZNF451	jaspar__MA0748.2	YY2 (directAnnotation).
ZNF451	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
ZNF451	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ZNF451	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
ZNF451	jaspar__MA1460.1	YY1 (inferredBy_Orthology).
ZNF451	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
ZNF451	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
ZNF451	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
ZNF451	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
ZNF451	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
ZNF451	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
ZNF451	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ZNF451	metacluster_172.6	CHD2; E2F1 (directAnnotation).
ZNF451	hdpi__TIMELESS	TIMELESS (directAnnotation).
ZNF451	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_repr	ZNF385D (directAnnotation).
ZNF451	transfac_pro__M06340	ZNF790 (directAnnotation).
ZNF451	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
ZNF451	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
ZNF451	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).
ZNF451	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ZNF451	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ZNF451	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
ZNF451	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
ZNF451	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ZNF451	transfac_pro__M02913	SP140 (inferredBy_Orthology).
ZNF451	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ZNF451	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ZNF451	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
ZNF451	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ZNF451	cisbp__M00788	ZFY (inferredBy_Orthology).
ZNF451	transfac_pro__M00430	E2F1 (directAnnotation).
ZNF451	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ZNF451	transfac_pro__M04893	TAF1 (directAnnotation).
ZNF451	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ZNF451	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
ZNF451	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
ZNF451	hdpi__HIP2	UBE2K (directAnnotation).
ZNF451	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
ZNF451	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
ZNF451	metacluster_191.5	SPDEF (inferredBy_Orthology).
ZNF451	transfac_pro__M00938	E2F1 (directAnnotation).
ZNF451	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
ZNF451	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."