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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZNF444

Summary for ZNF444

Gene information	Gene symbol	ZNF444
	Ensembl ID	ENSG00000167685
	Entrez ID	55311
	Gene name	zinc finger protein 444
	Synonyms	EZF2\|FLJ11137\|ZSCAN17
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ZNF444

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.293527	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.260227	2.47e-40

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Expression of ZNF444 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZNF444

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZNF444

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZNF444	hsa-miR-765	99.7118	NM_001253792
ZNF444	hsa-miR-11181-3p	99.5384	NM_001253792
ZNF444	hsa-miR-1275	92.681	NM_001253792
ZNF444	hsa-miR-6770-5p	92.4862	NM_001253792
ZNF444	hsa-miR-4665-5p	90.9025	NM_001253792
ZNF444	hsa-miR-4441	90.7273	NM_018337
ZNF444	hsa-miR-4270	90.384	NM_018337
ZNF444	hsa-miR-12132	89.2634	NM_018337
ZNF444	hsa-miR-4306	88.6978	NM_018337
ZNF444	hsa-miR-6754-5p	88.613	NM_018337
ZNF444	hsa-miR-6731-5p	88.1541	NM_018337
ZNF444	hsa-miR-8085	88.1541	NM_018337
ZNF444	hsa-miR-3173-3p	84.5717	NM_018337
ZNF444	hsa-miR-12118	84.5717	NM_018337
ZNF444	hsa-miR-6891-5p	84.5717	NM_018337
ZNF444	hsa-miR-625-5p	84.5471	NM_018337
ZNF444	hsa-miR-185-5p	83.0209	NM_018337
ZNF444	hsa-miR-4644	83.0209	NM_018337
ZNF444	hsa-miR-4747-5p	82.2705	NM_018337
ZNF444	hsa-miR-5196-5p	82.2705	NM_018337
ZNF444	hsa-miR-4756-5p	80.7892	NM_001253792
ZNF444	hsa-miR-1321	80.7892	NM_001253792
ZNF444	hsa-miR-4739	80.7892	NM_001253792

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Motifs and transcription factors (TFs) regulating ZNF444

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZNF444	hdpi__ETV4	ETV4 (directAnnotation).
ZNF444	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
ZNF444	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
ZNF444	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."