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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZNF28

Summary for ZNF28

Gene information	Gene symbol	ZNF28
	Ensembl ID	ENSG00000198538
	Entrez ID	7576
	Gene name	zinc finger protein 28
	Synonyms	DKFZp781D0275\|KOX24
	Gene type	protein_coding
	UniProtAcc	P17035

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Dataset with differentially expressed gene: ZNF28

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.03403	3.92e-03

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Expression of ZNF28 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZNF28

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZNF28

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZNF28	hsa-miR-3064-3p	99.9072	NM_006969
ZNF28	hsa-miR-3925-3p	99.8019	NM_006969
ZNF28	hsa-miR-6833-3p	99.7223	NM_006969
ZNF28	hsa-miR-4768-5p	99.6339	NM_006969
ZNF28	hsa-miR-1272	98.5308	NM_006969
ZNF28	hsa-miR-624-3p	98.3687	NM_006969
ZNF28	hsa-miR-10393-5p	97.8624	NM_006969
ZNF28	hsa-miR-6809-3p	96.7877	NM_006969
ZNF28	hsa-miR-6873-3p	95.8104	NM_006969
ZNF28	hsa-miR-4452	94.8743	NM_006969
ZNF28	hsa-miR-513b-3p	94.0218	NM_006969
ZNF28	hsa-miR-766-3p	93.2777	NM_006969
ZNF28	hsa-miR-19b-2-5p	92.5681	NM_006969
ZNF28	hsa-miR-19b-1-5p	92.5681	NM_006969
ZNF28	hsa-miR-19a-5p	92.5681	NM_006969
ZNF28	hsa-miR-4698	92.5648	NM_006969
ZNF28	hsa-miR-6845-3p	92.1023	NM_006969
ZNF28	hsa-miR-6773-3p	91.8613	NM_006969
ZNF28	hsa-miR-17-3p	91.7674	NM_006969
ZNF28	hsa-miR-29b-3p	90.429	NM_006969
ZNF28	hsa-miR-29c-3p	90.429	NM_006969
ZNF28	hsa-miR-29a-3p	90.429	NM_006969
ZNF28	hsa-miR-12122	89.4947	NM_006969
ZNF28	hsa-miR-758-3p	89.2814	NM_006969
ZNF28	hsa-miR-296-3p	88.1746	NM_006969
ZNF28	hsa-miR-5682	87.9872	NM_006969
ZNF28	hsa-miR-1915-5p	87.4368	NM_006969
ZNF28	hsa-miR-519e-5p	87.4079	NM_006969
ZNF28	hsa-miR-515-5p	87.4079	NM_006969
ZNF28	hsa-miR-590-3p	87.3243	NM_006969
ZNF28	hsa-miR-6500-3p	87.1189	NM_006969
ZNF28	hsa-miR-134-5p	86.9322	NM_006969
ZNF28	hsa-miR-3118	86.9322	NM_006969
ZNF28	hsa-miR-12121	85.9048	NM_006969
ZNF28	hsa-miR-4715-3p	85.9048	NM_006969
ZNF28	hsa-miR-548d-3p	84.9122	NM_006969
ZNF28	hsa-miR-548ac	84.9122	NM_006969
ZNF28	hsa-miR-548h-3p	84.9122	NM_006969
ZNF28	hsa-miR-548z	84.9122	NM_006969
ZNF28	hsa-miR-548bb-3p	84.9122	NM_006969
ZNF28	hsa-miR-183-3p	84.2266	NM_006969
ZNF28	hsa-miR-3164	83.6217	NM_006969
ZNF28	hsa-miR-3143	83.4255	NM_006969
ZNF28	hsa-miR-1276	82.8537	NM_006969
ZNF28	hsa-miR-4748	82.4985	NM_006969
ZNF28	hsa-miR-4464	82.4985	NM_006969
ZNF28	hsa-miR-3148	82.0504	NM_006969
ZNF28	hsa-miR-4528	81.4128	NM_006969
ZNF28	hsa-miR-371b-5p	80.847	NM_006969
ZNF28	hsa-miR-373-5p	80.847	NM_006969

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Motifs and transcription factors (TFs) regulating ZNF28

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."