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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZNF260

Summary for ZNF260

Gene information	Gene symbol	ZNF260
	Ensembl ID	ENSG00000254004
	Entrez ID	339324
	Gene name	zinc finger protein 260
	Synonyms	ozrf1\|Zfp260
	Gene type	protein_coding
	UniProtAcc	Q3ZCT1

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Dataset with differentially expressed gene: ZNF260

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.26297	2.80e-18

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Expression of ZNF260 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZNF260

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZNF260

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZNF260	hsa-miR-656-3p	96.2461	NM_001166037
ZNF260	hsa-miR-144-3p	95.8932	NM_001166037
ZNF260	hsa-miR-5011-5p	95.0715	NM_001166037
ZNF260	hsa-miR-4775	94.5711	NM_001012756
ZNF260	hsa-miR-4666a-3p	92.8463	NM_001166037
ZNF260	hsa-miR-3123	91.7255	NM_001166037
ZNF260	hsa-miR-138-2-3p	90.402	NM_001166037
ZNF260	hsa-miR-3143	89.947	NM_001166037
ZNF260	hsa-miR-1277-5p	88.975	NM_001166037
ZNF260	hsa-miR-3662	88.1722	NM_001166037
ZNF260	hsa-miR-616-5p	87.9347	NM_001166037
ZNF260	hsa-miR-371b-5p	87.9347	NM_001166037
ZNF260	hsa-miR-373-5p	87.9347	NM_001166037
ZNF260	hsa-miR-3928-3p	86.7561	NM_001166037
ZNF260	hsa-miR-499a-3p	85.668	NM_001166037
ZNF260	hsa-miR-499b-3p	85.668	NM_001166037
ZNF260	hsa-miR-548ar-3p	84.6258	NM_001166037
ZNF260	hsa-miR-302e	84.6201	NM_001166037
ZNF260	hsa-miR-4495	80.7705	NM_001166037
ZNF260	hsa-miR-4680-3p	80.6333	NM_001166037
ZNF260	hsa-miR-302b-3p	80.2746	NM_001166037
ZNF260	hsa-miR-302c-3p	80.2746	NM_001166037
ZNF260	hsa-miR-302d-3p	80.2746	NM_001166037
ZNF260	hsa-miR-302a-3p	80.2746	NM_001166037
ZNF260	hsa-miR-548bc	80.0698	NM_001166037
ZNF260	hsa-miR-548e-3p	80.0698	NM_001166037
ZNF260	hsa-miR-548a-3p	80.0698	NM_001166037
ZNF260	hsa-miR-548f-3p	80.0698	NM_001166037
ZNF260	hsa-miR-548az-3p	80.0698	NM_001166037

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Motifs and transcription factors (TFs) regulating ZNF260

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZNF260	jaspar__MA1933.1	SREBF2 (directAnnotation).
ZNF260	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
ZNF260	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ZNF260	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ZNF260	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ZNF260	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
ZNF260	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."