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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZNF24

Summary for ZNF24

Gene information	Gene symbol	ZNF24
	Ensembl ID	ENSG00000172466
	Entrez ID	7572
	Gene name	zinc finger protein 24
	Synonyms	KOX17\|Zfp191\|ZNF191\|ZSCAN3
	Gene type	protein_coding
	UniProtAcc	P17028

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Dataset with differentially expressed gene: ZNF24

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.645431	2.18e-02
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.396182	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.291839	4.07e-18
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.486706	0.00e+00

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Expression of ZNF24 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZNF24

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZNF24

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZNF24	hsa-miR-1468-3p	98.5255	NM_006965
ZNF24	hsa-miR-548x-3p	96.2224	NM_006965
ZNF24	hsa-miR-548aj-3p	96.2224	NM_006965
ZNF24	hsa-miR-548ae-3p	95.3651	NM_006965
ZNF24	hsa-miR-548am-3p	95.3651	NM_006965
ZNF24	hsa-miR-548ah-3p	95.3651	NM_006965
ZNF24	hsa-miR-548aq-3p	95.3651	NM_006965
ZNF24	hsa-miR-548j-3p	95.3651	NM_006965
ZNF24	hsa-miR-6835-3p	95.1176	NM_006965
ZNF24	hsa-miR-6892-5p	92.6245	NM_006965
ZNF24	hsa-miR-3148	92.1816	NM_006965
ZNF24	hsa-miR-4717-3p	91.7018	NM_006965
ZNF24	hsa-miR-92a-3p	91.5255	NM_001308123
ZNF24	hsa-miR-32-5p	91.5255	NM_001308123
ZNF24	hsa-miR-92b-3p	91.5255	NM_001308123
ZNF24	hsa-miR-6758-5p	91.2818	NM_006965
ZNF24	hsa-miR-12131	89.8848	NM_006965
ZNF24	hsa-miR-363-3p	89.7383	NM_001308123
ZNF24	hsa-miR-25-3p	89.7383	NM_001308123
ZNF24	hsa-miR-367-3p	89.7383	NM_001308123
ZNF24	hsa-miR-12124	89.0497	NM_006965
ZNF24	hsa-miR-5692a	88.416	NM_006965
ZNF24	hsa-miR-6856-5p	88.0616	NM_006965
ZNF24	hsa-miR-1-3p	87.7199	NM_006965
ZNF24	hsa-miR-206	87.7199	NM_006965
ZNF24	hsa-miR-520e-5p	87.6749	NM_006965
ZNF24	hsa-miR-5193	87.3001	NM_006965
ZNF24	hsa-miR-4282	87.1711	NM_006965
ZNF24	hsa-miR-4719	87.1254	NM_006965
ZNF24	hsa-miR-613	87.1045	NM_006965
ZNF24	hsa-miR-3133	85.4304	NM_006965
ZNF24	hsa-miR-105-5p	84.3215	NM_006965
ZNF24	hsa-miR-7853-5p	84.3215	NM_006965
ZNF24	hsa-miR-101-3p	83.8903	NM_006965
ZNF24	hsa-miR-4499	83.6281	NM_006965
ZNF24	hsa-miR-4531	83.1068	NM_006965
ZNF24	hsa-miR-4493	82.7127	NM_006965
ZNF24	hsa-miR-7844-5p	82.2564	NM_006965
ZNF24	hsa-miR-877-3p	82.1722	NM_006965
ZNF24	hsa-miR-4762-3p	82.0149	NM_006965
ZNF24	hsa-miR-511-5p	81.3649	NM_006965
ZNF24	hsa-miR-95-5p	81.2295	NM_006965
ZNF24	hsa-miR-4475	80.8798	NM_006965
ZNF24	hsa-miR-512-3p	80.8222	NM_006965

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Motifs and transcription factors (TFs) regulating ZNF24

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZNF24	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ZNF24	transfac_pro__M07397	ZNF148 (directAnnotation).
ZNF24	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
ZNF24	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
ZNF24	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ZNF24	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
ZNF24	transfac_pro__M01175	ZBTB7B (directAnnotation).
ZNF24	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ZNF24	tfdimers__MD00151	CHURC1 (directAnnotation).
ZNF24	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ZNF24	transfac_pro__M01303	SP1 (directAnnotation).
ZNF24	transfac_pro__M02090	E2F4 (directAnnotation).
ZNF24	transfac_pro__M01714	KLF15 (directAnnotation).
ZNF24	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
ZNF24	transfac_pro__M02089	E2F3 (directAnnotation).
ZNF24	metacluster_3.14	WT1; WT1 (directAnnotation).
ZNF24	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ZNF24	cisbp__M07938	E2F1 (directAnnotation).
ZNF24	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
ZNF24	transfac_pro__M02281	SP1 (directAnnotation).
ZNF24	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ZNF24	transfac_pro__M02898	SMAD3 (directAnnotation).
ZNF24	transfac_public__M00491	PATZ1 (directAnnotation).
ZNF24	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
ZNF24	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ZNF24	hdpi__HIP2	UBE2K (directAnnotation).
ZNF24	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ZNF24	transfac_pro__M04893	TAF1 (directAnnotation).
ZNF24	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ZNF24	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
ZNF24	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
ZNF24	jaspar__MA1933.1	SREBF2 (directAnnotation).
ZNF24	swissregulon__hs__ETV6	ETV6 (directAnnotation).
ZNF24	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
ZNF24	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
ZNF24	transfac_pro__M05817	ZNF546 (directAnnotation).
ZNF24	hdpi__ETV4	ETV4 (directAnnotation).
ZNF24	metacluster_135.11	NR2C2 (directAnnotation).
ZNF24	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ZNF24	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ZNF24	cisbp__M00968	MTF2 (directAnnotation).
ZNF24	cisbp__M00341	PAX6 (directAnnotation).
ZNF24	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ZNF24	hdpi__ZNF304	ZNF304 (directAnnotation).
ZNF24	transfac_pro__M02844	BCL6B (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."