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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZNF207

Summary for ZNF207

Gene information	Gene symbol	ZNF207
	Ensembl ID	ENSG00000010244
	Entrez ID	7756
	Gene name	zinc finger protein 207
	Synonyms	BuGZ
	Gene type	protein_coding
	UniProtAcc	O43670

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Dataset with differentially expressed gene: ZNF207

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.274681	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.265602	5.25e-35
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.346098	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.278025	4.64e-08
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.28093	1.37e-10
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.263995	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.448049	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.320432	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.452342	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	-0.295955	7.65e-03
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.304664	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.29281	0.00e+00

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Expression of ZNF207 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZNF207

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZNF207

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZNF207	hsa-miR-10523-5p	96.6672	NM_001032293
ZNF207	hsa-miR-4463	95.5669	NM_001032293
ZNF207	hsa-miR-8068	95.1673	NM_001032293
ZNF207	hsa-miR-299-3p	93.274	NM_001032293
ZNF207	hsa-miR-6833-3p	92.672	NM_001032293
ZNF207	hsa-miR-1206	92.4063	NM_001032293
ZNF207	hsa-miR-144-3p	91.6748	NM_001032293
ZNF207	hsa-miR-4768-5p	91.182	NM_001032293
ZNF207	hsa-miR-891b	90.2965	NM_001032293
ZNF207	hsa-miR-519e-5p	87.233	NM_001032293
ZNF207	hsa-miR-515-5p	87.233	NM_001032293
ZNF207	hsa-miR-605-3p	86.6273	NM_001032293
ZNF207	hsa-miR-548z	86.5482	NM_001032293
ZNF207	hsa-miR-548h-3p	86.5482	NM_001032293
ZNF207	hsa-miR-548ac	86.5482	NM_001032293
ZNF207	hsa-miR-548d-3p	86.5482	NM_001032293
ZNF207	hsa-miR-548bb-3p	86.5482	NM_001032293
ZNF207	hsa-miR-6810-5p	85.5115	NM_001032293
ZNF207	hsa-miR-4786-3p	85.4915	NM_001032293
ZNF207	hsa-miR-519d-5p	84.9236	NM_001032293
ZNF207	hsa-miR-494-3p	84.4802	NM_001032293
ZNF207	hsa-miR-6516-3p	84.4425	NM_001032293
ZNF207	hsa-miR-6856-3p	81.9258	NM_001032293

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Motifs and transcription factors (TFs) regulating ZNF207

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZNF207	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
ZNF207	jaspar__MA0748.2	YY2 (directAnnotation).
ZNF207	jaspar__MA1460.1	YY1 (inferredBy_Orthology).
ZNF207	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
ZNF207	metacluster_172.6	CHD2; E2F1 (directAnnotation).
ZNF207	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
ZNF207	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
ZNF207	transfac_pro__M04944	GABPA (directAnnotation).
ZNF207	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
ZNF207	metacluster_141.9	TAF1; YY1; YY1 (directAnnotation).
ZNF207	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
ZNF207	hdpi__TP73	TP73 (directAnnotation).
ZNF207	transfac_pro__M07483	CXXC1 (directAnnotation).
ZNF207	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ZNF207	metacluster_175.1	ZNF283 (directAnnotation).
ZNF207	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."