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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZNF12

Summary for ZNF12

Gene information	Gene symbol	ZNF12
	Ensembl ID	ENSG00000164631
	Entrez ID	7559
	Gene name	zinc finger protein 12
	Synonyms	GIOT-3\|KOX3\|ZNF325
	Gene type	protein_coding
	UniProtAcc	P17014

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Dataset with differentially expressed gene: ZNF12

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.251684	4.32e-16

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Expression of ZNF12 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZNF12

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZNF12

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZNF12	hsa-miR-12125	94.001	NM_006956
ZNF12	hsa-miR-5700	93.7892	NM_006956
ZNF12	hsa-let-7c-3p	93.5367	NM_006956
ZNF12	hsa-miR-582-5p	91.6237	NM_006956
ZNF12	hsa-miR-1305	90.4108	NM_006956
ZNF12	hsa-miR-570-3p	89.0865	NM_006956
ZNF12	hsa-miR-607	87.5691	NM_006956
ZNF12	hsa-miR-4653-5p	86.8827	NM_006956
ZNF12	hsa-miR-3921	86.8827	NM_006956
ZNF12	hsa-miR-10522-5p	86.8298	NM_006956
ZNF12	hsa-miR-202-5p	85.8884	NM_006956
ZNF12	hsa-miR-3144-3p	85.1958	NM_006956
ZNF12	hsa-miR-1297	85.0904	NM_006956
ZNF12	hsa-miR-2116-5p	85.0191	NM_006956
ZNF12	hsa-miR-301a-5p	84.7681	NM_006956
ZNF12	hsa-miR-301b-5p	84.7681	NM_006956
ZNF12	hsa-miR-146a-3p	84.7681	NM_006956
ZNF12	hsa-miR-4635	84.4938	NM_006956
ZNF12	hsa-miR-512-3p	82.4706	NM_006956
ZNF12	hsa-miR-4482-3p	82.4629	NM_006956
ZNF12	hsa-miR-3064-5p	82.1891	NM_006956
ZNF12	hsa-miR-6504-5p	82.1891	NM_006956
ZNF12	hsa-miR-3085-3p	82.1891	NM_006956
ZNF12	hsa-miR-670-5p	80.599	NM_006956
ZNF12	hsa-miR-138-2-3p	80.2552	NM_006956

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Motifs and transcription factors (TFs) regulating ZNF12

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZNF12	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
ZNF12	metacluster_7.13	ZFX (directAnnotation).
ZNF12	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ZNF12	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ZNF12	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ZNF12	transfac_pro__M05432	ZSCAN18 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."