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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZNF117

Summary for ZNF117

Gene information	Gene symbol	ZNF117
	Ensembl ID	ENSG00000152926
	Entrez ID	51351
	Gene name	zinc finger protein 117
	Synonyms	H-plk\|HPF9
	Gene type	protein_coding
	UniProtAcc	Q03924

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Dataset with differentially expressed gene: ZNF117

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	2.82172	0.00e+00

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Expression of ZNF117 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZNF117

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZNF117

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZNF117	hsa-miR-3925-3p	99.9999	NM_015852
ZNF117	hsa-miR-6833-3p	99.9984	NM_015852
ZNF117	hsa-miR-3064-3p	99.998	NM_015852
ZNF117	hsa-miR-4768-5p	99.9977	NM_015852
ZNF117	hsa-miR-6873-3p	99.8105	NM_015852
ZNF117	hsa-miR-10393-5p	99.6496	NM_015852
ZNF117	hsa-miR-6845-3p	99.1987	NM_015852
ZNF117	hsa-miR-6809-3p	98.9357	NM_015852
ZNF117	hsa-miR-296-3p	98.8348	NM_015852
ZNF117	hsa-miR-4715-3p	98.6866	NM_015852
ZNF117	hsa-miR-12121	98.6866	NM_015852
ZNF117	hsa-miR-4776-3p	98.3656	NM_015852
ZNF117	hsa-miR-23a-3p	97.6143	NM_015852
ZNF117	hsa-miR-23b-3p	97.6143	NM_015852
ZNF117	hsa-miR-23c	96.8034	NM_015852
ZNF117	hsa-miR-511-3p	96.396	NM_015852
ZNF117	hsa-miR-590-3p	96.3896	NM_015852
ZNF117	hsa-miR-216b-3p	96.3496	NM_015852
ZNF117	hsa-miR-4464	95.5997	NM_015852
ZNF117	hsa-miR-4748	95.5997	NM_015852
ZNF117	hsa-miR-4775	95.4238	NM_015852
ZNF117	hsa-miR-548e-5p	93.94	NM_015852
ZNF117	hsa-miR-6837-3p	93.3094	NM_015852
ZNF117	hsa-miR-3924	93.1956	NM_015852
ZNF117	hsa-miR-4452	93.1276	NM_015852
ZNF117	hsa-miR-561-3p	92.6705	NM_015852
ZNF117	hsa-miR-1251-3p	92.4508	NM_015852
ZNF117	hsa-miR-124-5p	90.1585	NM_015852
ZNF117	hsa-miR-412-3p	89.7956	NM_015852
ZNF117	hsa-miR-16-2-3p	89.2016	NM_015852
ZNF117	hsa-miR-195-3p	89.2016	NM_015852
ZNF117	hsa-miR-6754-3p	89.193	NM_015852
ZNF117	hsa-miR-6768-3p	88.9971	NM_015852
ZNF117	hsa-miR-148a-5p	88.9374	NM_015852
ZNF117	hsa-miR-5681a	88.5224	NM_015852
ZNF117	hsa-miR-766-3p	88.3251	NM_015852
ZNF117	hsa-miR-4712-5p	87.9031	NM_015852
ZNF117	hsa-miR-770-5p	87.9031	NM_015852
ZNF117	hsa-miR-548at-5p	87.1018	NM_015852
ZNF117	hsa-miR-186-5p	86.6141	NM_015852
ZNF117	hsa-miR-342-3p	86.3822	NM_015852
ZNF117	hsa-miR-3692-3p	86.0982	NM_015852
ZNF117	hsa-miR-6507-5p	84.342	NM_015852
ZNF117	hsa-miR-219a-1-3p	84.1893	NM_015852
ZNF117	hsa-miR-6500-3p	84.1466	NM_015852
ZNF117	hsa-miR-3679-5p	82.5834	NM_015852
ZNF117	hsa-miR-585-5p	82.4013	NM_015852
ZNF117	hsa-miR-627-3p	82.2254	NM_015852
ZNF117	hsa-miR-6811-5p	82.1951	NM_015852
ZNF117	hsa-miR-6511b-5p	82.1951	NM_015852

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Motifs and transcription factors (TFs) regulating ZNF117

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."