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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZMYM5

Summary for ZMYM5

Gene information	Gene symbol	ZMYM5
	Ensembl ID	ENSG00000132950
	Entrez ID	9205
	Gene name	zinc finger MYM-type containing 5
	Synonyms	MYM\|ZNF198L1\|ZNF237
	Gene type	protein_coding
	UniProtAcc	Q9UJ78

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Dataset with differentially expressed gene: ZMYM5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.35331	1.49e-20

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Expression of ZMYM5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZMYM5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZMYM5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZMYM5	hsa-miR-4317	97.7555	NM_001142684
ZMYM5	hsa-miR-4803	97.5208	NM_001142684
ZMYM5	hsa-miR-3163	97.015	NM_001039649
ZMYM5	hsa-miR-31-3p	95.1667	NM_001039649
ZMYM5	hsa-miR-548aa	94.6603	NM_001142684
ZMYM5	hsa-miR-548ap-3p	94.6603	NM_001142684
ZMYM5	hsa-miR-548t-3p	94.6603	NM_001142684
ZMYM5	hsa-miR-4760-5p	92.6257	NM_001142684
ZMYM5	hsa-miR-125b-2-3p	92.3192	NM_001142684
ZMYM5	hsa-miR-4773	90.3671	NM_001142684
ZMYM5	hsa-miR-8061	89.665	NM_001142684
ZMYM5	hsa-miR-548at-5p	88.6078	NM_001039649
ZMYM5	hsa-miR-1286	88.2621	NM_001142684
ZMYM5	hsa-miR-5002-5p	88.1458	NM_001142684
ZMYM5	hsa-miR-4533	86.8483	NM_001039649
ZMYM5	hsa-miR-302c-5p	86.4861	NM_001142684
ZMYM5	hsa-miR-6767-3p	86.2494	NM_001039649
ZMYM5	hsa-miR-3686	84.7461	NM_001142684
ZMYM5	hsa-miR-3664-5p	84.0465	NM_001142684
ZMYM5	hsa-miR-145-5p	83.7407	NM_001039649
ZMYM5	hsa-miR-5195-3p	83.7407	NM_001039649
ZMYM5	hsa-miR-1-5p	83.2237	NM_001142684
ZMYM5	hsa-miR-19b-2-5p	82.416	NM_001142684
ZMYM5	hsa-miR-19a-5p	82.416	NM_001142684
ZMYM5	hsa-miR-19b-1-5p	82.416	NM_001142684
ZMYM5	hsa-miR-5688	81.774	NM_001142684
ZMYM5	hsa-miR-7-1-3p	81.7186	NM_001142684
ZMYM5	hsa-miR-7-2-3p	81.7186	NM_001142684
ZMYM5	hsa-miR-371a-5p	81.7073	NM_001142684
ZMYM5	hsa-miR-331-5p	81.1784	NM_001039649
ZMYM5	hsa-miR-493-5p	81.0443	NM_001039649

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Motifs and transcription factors (TFs) regulating ZMYM5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZMYM5	metacluster_135.11	NR2C2 (directAnnotation).
ZMYM5	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ZMYM5	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ZMYM5	metacluster_7.13	ZFX (directAnnotation).
ZMYM5	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ZMYM5	cisbp__M00968	MTF2 (directAnnotation).
ZMYM5	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ZMYM5	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ZMYM5	cisbp__M00341	PAX6 (directAnnotation).
ZMYM5	metacluster_198.3	ZFP64 (directAnnotation).
ZMYM5	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ZMYM5	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ZMYM5	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ZMYM5	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ZMYM5	cisbp__M00788	ZFY (inferredBy_Orthology).
ZMYM5	metacluster_175.1	ZNF283 (directAnnotation).
ZMYM5	hdpi__ZNF304	ZNF304 (directAnnotation).
ZMYM5	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ZMYM5	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ZMYM5	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ZMYM5	transfac_pro__M01199	TRIM28 (directAnnotation).
ZMYM5	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ZMYM5	metacluster_151.2	ZNF23 (directAnnotation).
ZMYM5	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ZMYM5	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ZMYM5	transfac_pro__M03806	ZBTB7C (directAnnotation).
ZMYM5	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."