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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZMYM2

Summary for ZMYM2

Gene information	Gene symbol	ZMYM2
	Ensembl ID	ENSG00000121741
	Entrez ID	7750
	Gene name	zinc finger MYM-type containing 2
	Synonyms	FIM\|MYM\|RAMP\|ZNF198
	Gene type	protein_coding
	UniProtAcc	Q9UBW7

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Dataset with differentially expressed gene: ZMYM2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.373546	1.56e-31
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.292797	8.25e-07

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Expression of ZMYM2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZMYM2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZMYM2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZMYM2	hsa-miR-5011-5p	100	NM_197968
ZMYM2	hsa-miR-190a-3p	99.9973	NM_197968
ZMYM2	hsa-miR-3148	98.6166	NM_197968
ZMYM2	hsa-miR-4495	98.5055	NM_001190964
ZMYM2	hsa-miR-187-5p	98.006	NM_001190964
ZMYM2	hsa-miR-137-3p	97.6951	NM_001190964
ZMYM2	hsa-miR-8063	97.2	NM_197968
ZMYM2	hsa-miR-548aa	96.8295	NM_001190964
ZMYM2	hsa-miR-548ap-3p	96.8295	NM_001190964
ZMYM2	hsa-miR-548t-3p	96.8295	NM_001190964
ZMYM2	hsa-miR-4668-5p	96.6714	NM_197968
ZMYM2	hsa-miR-587	96.3877	NM_197968
ZMYM2	hsa-miR-1283	96.3022	NM_001190964
ZMYM2	hsa-miR-548n	96.2147	NM_197968
ZMYM2	hsa-miR-4729	96.2117	NM_197968
ZMYM2	hsa-miR-4799-5p	96.1132	NM_001190964
ZMYM2	hsa-miR-1305	95.7884	NM_197968
ZMYM2	hsa-miR-1226-3p	94.9964	NM_197968
ZMYM2	hsa-miR-4698	94.3034	NM_197968
ZMYM2	hsa-miR-3942-3p	94.2282	NM_197968
ZMYM2	hsa-miR-3130-5p	93.4957	NM_001190964
ZMYM2	hsa-miR-548as-3p	93.2532	NM_001190964
ZMYM2	hsa-miR-548c-3p	93.0907	NM_197968
ZMYM2	hsa-miR-4482-5p	92.8	NM_001190964
ZMYM2	hsa-miR-449b-3p	92.606	NM_001190964
ZMYM2	hsa-miR-582-5p	92.5881	NM_001190964
ZMYM2	hsa-miR-155-5p	92.2587	NM_001190964
ZMYM2	hsa-miR-15b-5p	92.1746	NM_001190964
ZMYM2	hsa-miR-15a-5p	92.1746	NM_001190964
ZMYM2	hsa-miR-195-5p	92.1746	NM_001190964
ZMYM2	hsa-miR-16-5p	92.1746	NM_001190964
ZMYM2	hsa-miR-101-3p	91.0784	NM_001190964
ZMYM2	hsa-miR-12136	90.9639	NM_001190964
ZMYM2	hsa-miR-376c-3p	90.8103	NM_197968
ZMYM2	hsa-miR-3129-3p	90.7231	NM_001190964
ZMYM2	hsa-miR-5583-5p	90.7231	NM_001190964
ZMYM2	hsa-miR-3936	90.5101	NM_197968
ZMYM2	hsa-miR-936	90.3485	NM_197968
ZMYM2	hsa-miR-5197-5p	90.216	NM_197968
ZMYM2	hsa-miR-4753-3p	89.9034	NM_197968
ZMYM2	hsa-miR-3671	89.8533	NM_001190964
ZMYM2	hsa-miR-150-3p	89.8493	NM_001190964
ZMYM2	hsa-miR-186-5p	89.8134	NM_197968
ZMYM2	hsa-miR-23a-3p	89.5408	NM_001190964
ZMYM2	hsa-miR-23c	89.5408	NM_001190964
ZMYM2	hsa-miR-23b-3p	89.5408	NM_001190964
ZMYM2	hsa-miR-3163	89.3091	NM_001190964
ZMYM2	hsa-miR-5692a	89.2786	NM_001190964
ZMYM2	hsa-miR-6758-3p	88.8277	NM_197968
ZMYM2	hsa-miR-6838-5p	88.4103	NM_001190964

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Motifs and transcription factors (TFs) regulating ZMYM2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZMYM2	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
ZMYM2	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
ZMYM2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ZMYM2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ZMYM2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ZMYM2	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
ZMYM2	transfac_pro__M12686	ZBTB10 (directAnnotation).
ZMYM2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ZMYM2	metacluster_143.14	ZNF320 (directAnnotation).
ZMYM2	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
ZMYM2	dbtfbs__ZBTB10_HEK293_ENCSR004PLU_merged_N1	ZBTB10 (directAnnotation).
ZMYM2	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
ZMYM2	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
ZMYM2	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
ZMYM2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ZMYM2	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
ZMYM2	kznf__ZNF141_Imbeault2017_RP_RCADE	ZNF141 (directAnnotation).
ZMYM2	transfac_pro__M04617	ZBTB7A (directAnnotation).
ZMYM2	transfac_pro__M01973	PLAG1 (directAnnotation).
ZMYM2	metacluster_151.2	ZNF23 (directAnnotation).
ZMYM2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ZMYM2	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
ZMYM2	metacluster_66.1	MTF1; ZNF320; ZNF320; ZNF320; ZNF782 (directAnnotation).
ZMYM2	cisbp__M01864	EGR1 (inferredBy_Orthology).
ZMYM2	tfdimers__MD00391	KLF4 (directAnnotation).
ZMYM2	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
ZMYM2	tfdimers__MD00151	CHURC1 (directAnnotation).
ZMYM2	transfac_pro__M04817	ZBTB33 (directAnnotation).
ZMYM2	cisbp__M00139	ZNF281 (inferredBy_Orthology).
ZMYM2	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
ZMYM2	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
ZMYM2	transfac_public__M00491	PATZ1 (directAnnotation).
ZMYM2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ZMYM2	metacluster_3.10	KLF2; KLF4 (directAnnotation).
ZMYM2	jaspar__MA1122.1	TFDP1 (directAnnotation).
ZMYM2	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
ZMYM2	transfac_pro__M01253	CNOT3 (directAnnotation).
ZMYM2	metacluster_159.5	ZIC1; ZIC4; ZNF423 (directAnnotation). SP1 (inferredBy_Orthology).
ZMYM2	cisbp__M00968	MTF2 (directAnnotation).
ZMYM2	tfdimers__MD00038	TFAP2C (directAnnotation).
ZMYM2	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
ZMYM2	transfac_pro__M01199	TRIM28 (directAnnotation).
ZMYM2	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
ZMYM2	metacluster_3.14	WT1; WT1 (directAnnotation).
ZMYM2	transfac_pro__M12697	ZNF142 (directAnnotation).
ZMYM2	metacluster_84.2	RARA (directAnnotation).
ZMYM2	transfac_pro__M01122	ZNF219 (directAnnotation).
ZMYM2	transfac_pro__M07387	ZBTB7A (directAnnotation).
ZMYM2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ZMYM2	transfac_pro__M04893	TAF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."